在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat ADP/ATP translocase 1 (Slc25a4), partial

Recombinant Rat ADP/ATP translocase 1 (Slc25a4), partial

  • 中文名稱：
    大鼠Slc25a4重組蛋白
  • 貨號：
    CSB-YP021510RA1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Slc25a4重組蛋白
  • 貨號：
    CSB-EP021510RA1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Slc25a4重組蛋白
  • 貨號：
    CSB-EP021510RA1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Slc25a4重組蛋白
  • 貨號：
    CSB-BP021510RA1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Slc25a4重組蛋白
  • 貨號：
    CSB-MP021510RA1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Slc25a4; Aac1; Ant1; ADP/ATP translocase 1; ADP,ATP carrier protein 1; Adenine nucleotide translocator 1; ANT 1; Solute carrier family 25 member 4
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane. In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it. Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it. Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1.
  • 基因功能參考文獻：
    1. ANT1 overexpression compensates impaired adenine nucleotide translocase activity under oxygen-restricted conditions PMID: 27080394
    2. Our data suggest that conformational changes of ANT may be directly involved in the opening of the Tl(+)-induced mitochondrial permeability transition pore in the inner membrane of Ca(2+)-loaded rat liver mitochondria PMID: 26835787
    3. Adenine nucleotide translocase 1 overexpression protects cardiomyocytes against hypoxia PMID: 26548633
    4. The findings reported in this paper demonstrate that ADP inhibits the proapoptotic stimulus supposedly via: i) inhibition of ROS production during early stages of apoptosis, an effect mediated by its interaction with cell receptor/s. PMID: 24709060
    5. carbon monoxide protects astrocytes from apoptosis by preventing MMP, acting on ANT (glutathionylation and inhibition of its pore activity) via a preconditioning-like process mediated by ROS and GSSG PMID: 20348099
    6. These data suggest a likely enzymatic involvement in the interaction between ANT and coenzyme A. PMID: 19800022
    7. Upregulation of Ant1 in the developing rat heart correlates with changes in mitochondrial membrane potential. PMID: 12676547
    8. The astrocytic response to CNS injury includes an apparent increase in energy mobilization capacity by Ant1 that contributes to neuroprotective, energy-dependent glutamate uptake PMID: 12781988
    9. the adenine nucleotide translocator-mediated mitochondrial permeability transition is impaired by cholesterol through altered membrane fluidity PMID: 12821666
    10. apoptosis of cardiomyocytes is an important regulatory mechanism that is involved in the cardiac adaptive response to pressure overload, and the apoptosis of cardiomyocytes is mediated, in part, by ANT1 PMID: 16501242
    11. These data suggest that hepatic accumulation of fat impairs mitochondrial function, reflecting the loss of oxidative phosphorylation capacity caused by a decrease in the ANT content. PMID: 16554051
    12. Myocardial ANT1 overexpression protects against hypertension-induced cardiac pathology. PMID: 17210842
    13. The target site for Cu(2+) is located in the ADP/ATP carrier. PMID: 17485229

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Mitochondrial carrier (TC 2.A.29) family
  • 數據庫鏈接：


主站蜘蛛池模板： 好吊射视频988gaocom| 亚洲成a人片在线不卡一二三区| 在线视频国产制服丝袜| 亚洲成a人片在线观看你懂的| 美女无遮挡免费视频网站| 国产午夜三级一区二区三| 五月综合色婷婷在线观看| 国产亚洲日韩在线a不卡| 老色鬼永久精品网站| 97精品人妻一区二区三区香蕉| 久久亚洲美女精品国产精品| 国产成人精品视觉盛宴| 欧美肥老太牲交大战| 国产欧美一区二区精品性色| 中文字幕人妻少妇引诱隔壁| 无码不卡中文字幕av| 中文午夜人妻无码看片| 精品无人国产偷自产在线| 久久人人爽人人爽人人片亞洲| 日本强伦片中文字幕免费看| 日本高清在线www3344| 国产午夜鲁丝片av无码| 亚洲精品夜夜夜| 久久影视久久午夜| 精品久久久无码中文字幕一丶| 国产欧美亚洲日韩图片| 久久亚洲中文字幕无码| 亚洲乱亚洲乱妇24p| 手机看黄av免费网址| 亚洲精品中文字幕一区二区三区| 成人国产一区二区三区| 成人无码视频在线观看大全| 在线人成免费视频69国产| 亚洲裸男gv网站| 亚洲精品蜜桃久久久久久| 特黄做受又硬又粗又大视频小说| 波多野结衣av高清一区二区三区| 色欲国产麻豆一精品一av一免费 | 亚洲 日本 欧美 中文字幕| 一边摸一边做爽的免费视频日本| 肉岳疯狂69式激情的高潮|