在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat ADP/ATP translocase 1 (Slc25a4), partial

Recombinant Rat ADP/ATP translocase 1 (Slc25a4), partial

  • 中文名稱：
    大鼠Slc25a4重組蛋白
  • 貨號：
    CSB-YP021510RA1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Slc25a4重組蛋白
  • 貨號：
    CSB-EP021510RA1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Slc25a4重組蛋白
  • 貨號：
    CSB-EP021510RA1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Slc25a4重組蛋白
  • 貨號：
    CSB-BP021510RA1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Slc25a4重組蛋白
  • 貨號：
    CSB-MP021510RA1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Slc25a4; Aac1; Ant1; ADP/ATP translocase 1; ADP,ATP carrier protein 1; Adenine nucleotide translocator 1; ANT 1; Solute carrier family 25 member 4
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane. In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it. Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it. Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1.
  • 基因功能參考文獻：
    1. ANT1 overexpression compensates impaired adenine nucleotide translocase activity under oxygen-restricted conditions PMID: 27080394
    2. Our data suggest that conformational changes of ANT may be directly involved in the opening of the Tl(+)-induced mitochondrial permeability transition pore in the inner membrane of Ca(2+)-loaded rat liver mitochondria PMID: 26835787
    3. Adenine nucleotide translocase 1 overexpression protects cardiomyocytes against hypoxia PMID: 26548633
    4. The findings reported in this paper demonstrate that ADP inhibits the proapoptotic stimulus supposedly via: i) inhibition of ROS production during early stages of apoptosis, an effect mediated by its interaction with cell receptor/s. PMID: 24709060
    5. carbon monoxide protects astrocytes from apoptosis by preventing MMP, acting on ANT (glutathionylation and inhibition of its pore activity) via a preconditioning-like process mediated by ROS and GSSG PMID: 20348099
    6. These data suggest a likely enzymatic involvement in the interaction between ANT and coenzyme A. PMID: 19800022
    7. Upregulation of Ant1 in the developing rat heart correlates with changes in mitochondrial membrane potential. PMID: 12676547
    8. The astrocytic response to CNS injury includes an apparent increase in energy mobilization capacity by Ant1 that contributes to neuroprotective, energy-dependent glutamate uptake PMID: 12781988
    9. the adenine nucleotide translocator-mediated mitochondrial permeability transition is impaired by cholesterol through altered membrane fluidity PMID: 12821666
    10. apoptosis of cardiomyocytes is an important regulatory mechanism that is involved in the cardiac adaptive response to pressure overload, and the apoptosis of cardiomyocytes is mediated, in part, by ANT1 PMID: 16501242
    11. These data suggest that hepatic accumulation of fat impairs mitochondrial function, reflecting the loss of oxidative phosphorylation capacity caused by a decrease in the ANT content. PMID: 16554051
    12. Myocardial ANT1 overexpression protects against hypertension-induced cardiac pathology. PMID: 17210842
    13. The target site for Cu(2+) is located in the ADP/ATP carrier. PMID: 17485229

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Mitochondrial carrier (TC 2.A.29) family
  • 數據庫鏈接：


主站蜘蛛池模板： 国产av大陆精品一区二区三区| 欧美丰满熟妇bbb久久久| 国产亚洲精品成人aa片新蒲金| 人人妻人人澡人人爽人人精品电影 | 国内久久婷婷六月综合欲色啪| 亚洲精品成人av在线| 久久www免费人成一看片| 国产激情久久久久影院老熟女| 熟女人妻av粗壮巨龙| 国产精品女主播在线视频| 极品少妇被猛的白浆直喷白浆| 国产欧美久久一区二区| 午夜精品久久久久久久久| 国产在线精品一区二区在线看 | 太粗太深了太紧太爽了动态图男男| 国产午夜亚洲精品国产成人小说 | 强奷乱码中文字幕熟女一| 精品人妻一区二区三区四区在线| 伊人久久久av老熟妇色| 亚洲精品成人av观看| 国产玉足榨精视频在线观看| 精品人妻码一区二区三区| 午夜精品电影你懂的| 日韩精品无码人成视频| 在教室伦流澡到高潮hgl视频| 真实国产老熟女无套中出| 99精品国产兔费观看久久| 热の综合热の国产热の潮在线| 人妻激情文学| 亚洲国产av高清无码| 亚洲性av免费| 青青久久成人免费影院| 亚洲va中文字幕无码毛片| 成人精品一区二区三区中文字幕| 青青草国产精品免费观看| 中文字幕无码中文字幕有码a| 欧美人与性动交α欧美精品| 亚洲中文字幕无码爆乳app| 麻豆蜜桃av蜜臀av色欲av| 国产真实露脸乱子伦 | 国产综合在线观看|