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  4. Recombinant Rat 85 kDa calcium-independent phospholipase A2 (Pla2g6)

Recombinant Rat 85 kDa calcium-independent phospholipase A2 (Pla2g6)

  • 中文名稱：
    大鼠Pla2g6重組蛋白
  • 貨號：
    CSB-YP018104RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Pla2g6重組蛋白
  • 貨號：
    CSB-EP018104RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Pla2g6重組蛋白
  • 貨號：
    CSB-EP018104RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Pla2g6重組蛋白
  • 貨號：
    CSB-BP018104RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Pla2g6重組蛋白
  • 貨號：
    CSB-MP018104RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Pla2g6; Pnpla9; 85/88 kDa calcium-independent phospholipase A2; CaI-PLA2; EC 3.1.1.4; Group VI phospholipase A2; GVI PLA2; Intracellular membrane-associated calcium-independent phospholipase A2 beta; iPLA2-beta; Patatin-like phospholipase domain-containing protein 9; PNPLA9
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Calcium-independent phospholipase involved in phospholipid remodeling with implications in cellular membrane homeostasis, mitochondrial integrity and signal transduction. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 and A2 activity respectively), producing lysophospholipids that are used in deacylation-reacylation cycles. Hydrolyzes both saturated and unsaturated long fatty acyl chains in various glycerophospholipid classes such as phosphatidylcholines, phosphatidylethanolamines and phosphatidates, with a preference for hydrolysis at sn-2 position. Can further hydrolyze lysophospholipids carrying saturated fatty acyl chains (lysophospholipase activity). Upon oxidative stress, contributes to remodeling of mitochondrial phospholipids in pancreatic beta cells, in a repair mechanism to reduce oxidized lipid content. Preferentially hydrolyzes oxidized polyunsaturated fatty acyl chains from cardiolipins, yielding monolysocardiolipins that can be reacylated with unoxidized fatty acyls to regenerate native cardiolipin species. Hydrolyzes oxidized glycerophosphoethanolamines present in pancreatic islets, releasing oxidized polyunsaturated fatty acids such as hydroxyeicosatetraenoates (HETEs). Has thioesterase activity toward fatty-acyl CoA releasing CoA-SH known to facilitate fatty acid transport and beta-oxidation in mitochondria particularly in skeletal muscle. Plays a role in regulation of membrane dynamics and homeostasis. Selectively hydrolyzes sn-2 arachidonoyl group in plasmalogen phospholipids, structural components of lipid rafts and myelin. Regulates F-actin polymerization at the pseudopods, which is required for both speed and directionality of MCP1/CCL2-induced monocyte chemotaxis. Targets membrane phospholipids to produce potent lipid signaling messengers. Generates lysophosphatidate (LPA, 1-acyl-glycerol-3-phosphate), which acts via G-protein receptors in various cell types. Has phospholipase A2 activity toward platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), likely playing a role in inactivation of this potent proinflammatory signaling lipid. In response to glucose, amplifies calcium influx in pancreatic beta cells to promote INS secretion.
  • 基因功能參考文獻：
    1. Data suggest glucose-induced insulin secretion is first up-regulated (acute infection), then down-regulated (chronic infection) in beta cells infected with S. aureus; Pla2g4a is up-regulated in acute infection; Pla2g6 is up-regulated in chronic infection. PMID: 26632509
    2. membrane potential sensitive activity is the iPLA2gamma PMID: 26206229
    3. Leptin was shown to significantly inhibit the activity of iPLA2, which is considered to play crucial roles in non-apoptotic cell death, resulting in effective prevention of ischemia-induced myocyte death. PMID: 25979360
    4. the mitochondrial iPLA2 may help to coordinate local capillary blood flow with changing energy demands PMID: 24586040
    5. acts as an inhibitory modulator of NKCC2 activity in thick ascending limb PMID: 22218592
    6. cPLA(2) and iPLA(2) are involved in stimulating endothelial migration and proliferation in the presence of glioma conditioned culture medium. PMID: 21094175
    7. These findings indicate that inhibition of iPLA(2) results in excessive exocytosis through increased oxidative damage (or failure to repair such damage) and defects in mitochondrial function. PMID: 21116712
    8. iPLA2 is shown to have a regulatory role in the development of neuroinflammation through upregulation of divalent calcium ion signaling in the brain. PMID: 21178110
    9. reactive oxygen species-induced function of cardiac mitochondrial-iPLA2 may stand on a pro-survival side of ischemia-reperfusion injury PMID: 20406040
    10. iPLA(2) activation in response to acute ischemia in STZ-induced diabetic hearts is more pronounced than in control hearts and that this response is a significant contributor to arrhythmogenic conduction slowing. PMID: 21037228
    11. The results suggest that glucocorticoids increase calcium concentrations in myocytes and stimulate iPLA(2)-dependent calcium entry and that steroid induced muscle protein degradation may be regulated by increased iPLA(2) activity and calcium metabolism. PMID: 20107037
    12. Results provide evidence for endogenous proteolytic processing of iPLA(2)beta and redistribution of iPLA(2)beta variants in subcellular compartments. PMID: 20132906
    13. Mitochondrial iPLA(2) plays a role in the remodeling of cardiolipin's acyl composition. PMID: 19741254
    14. iPLA(2) plays a substantial role in the generation of endothelium-derived contracting factor evoked by acetylcholine. PMID: 20118407
    15. The agonist-stimulated release of arachidonic acid (AA) from cellular phospholipids in many cell types (e.g. myocytes, beta-cells, and neurons) has been demonstrated to be primarily mediated by calcium-independent phospholipases A(2) (iPLA(2)s). PMID: 12089145
    16. iPLA2 plays a role in thrombin-induced arachidonic acid release and growth in VSMC and these responses are mediated by p38 MAPK PMID: 12928445
    17. Type VI iPLA2 drives the onset of acute pleurisy through the synthesis of PGE2, LTB4, PAF, and IL-1beta. PMID: 15003994
    18. The GVIB iPLA2 is present in rat liver peroxisomes, organelles that synthesize plasmalogens and carry out fatty acid beta-oxidation. PMID: 15052324
    19. The iPLA2 inhibitor bromoenol lactone, when introduced into hippocampal CA1 pyramidal cells, generated a dose-dependent increase in the amplitude of AMPA receptor-mediated EPSPs. PMID: 15132431
    20. Activities of both enzymes increased upon their association, and iPLA(2)beta reaction products reduced CaMKIIbeta activity PMID: 15576376
    21. mitochondrial Ca(2+)-independent phospholipase A(2) may be an important factor governing cell death caused by necrosis or apoptosis PMID: 16407316
    22. These results cast doubt on the proposed mechanism involving iPLA2beta required for Ca2+ entry. PMID: 16854462
    23. the PKCalpha-cPLA(2) pathway appears to play a key role in the early phase of EC-pericyte interactions regulating blood retina or blood-brain barrier maturation. PMID: 17267947
    24. Thus, we identify a regulatory mechanism important for the brain, in which docosahexaenoic acid released from astrocytes by VIB Ca(2+)-independent phospholipase A(2) negatively controls prostaglandin production. PMID: 17555549
    25. The phospholipase iPLA2 specifically associated with the endosomal and exosomal membranes could be activated by reactive oxygen species (ROSs) produced during mitochondria degeneration. PMID: 17666570
    26. These results suggest an important role for iPLA2 in the cortex-striatum-thalamus-cortex circuitry. PMID: 17768607
    27. mechanism of vasodilatation by urocortin involves the regulation of iPLA2 and SOCE via the stimulation of a cAMP/PKA-dependent signal transduction cascade in rat coronary artery. PMID: 17885217
    28. Expression of iPLA(2)gamma or iPLA(2)beta induces cytoprotection against complement-dependent glomerular epithelial cell injury. PMID: 18171998
    29. the iPLA(2)beta-ceramide axis plays a critical role in activating the mitochondrial apoptotic pathway in insulin-secreting cells during ER stress PMID: 18936091
    30. a novel function of iPLA 2beta, related not to its phospholipase activity but to its thioesterase activity, which contributes to optimal fatty acid oxidation in skeletal muscle. PMID: 18937505

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  • 亞細胞定位：
    Cytoplasm. Cell membrane. Mitochondrion. Cell projection, pseudopodium.
  • 組織特異性：
    Expressed in pancreatic beta-cells. Expressed in skeletal muscle (at protein level).
  • 數據庫鏈接：


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