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  4. Recombinant Rat 3 beta-hydroxysteroid dehydrogenase type 5 (Hsd3b5), partial

Recombinant Rat 3 beta-hydroxysteroid dehydrogenase type 5 (Hsd3b5), partial

  • 中文名稱：
    大鼠Hsd3b5重組蛋白
  • 貨號：
    CSB-YP333247RA1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Hsd3b5重組蛋白
  • 貨號：
    CSB-EP333247RA1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Hsd3b5重組蛋白
  • 貨號：
    CSB-EP333247RA1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Hsd3b5重組蛋白
  • 貨號：
    CSB-BP333247RA1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Hsd3b5重組蛋白
  • 貨號：
    CSB-MP333247RA1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Hsd3b5
  • Uniprot No.：
  • 別名：
    Hsd3b5; Hsd3b; NADPH-dependent 3-keto-steroid reductase Hsd3b5; 3 beta-hydroxysteroid dehydrogenase type 3; 3 beta-hydroxysteroid dehydrogenase type III; 3 beta-HSD III; Dihydrotestosterone 3-ketoreductase
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone. Does not function as an isomerase.
  • 基因功能參考文獻：
    1. Expression of Hsd3b throughout the spinal cord even after castration and adrenalectomy suggests a potential endogenous production of progesterone and an important signalling function of this steroid in the spinal cord. PMID: 12182894
    2. In ovariectomized-adrenalectomized rats, estrogen treatment increased 3beta-HSD mRNA in the hypothalamus. PMID: 16020475
    3. Significant decrease in the 3beta-HSD mRNA expression in traumatic brain injury site within the frontal cortex in both males and pseudopregnant females. PMID: 17428656
    4. ERalpha interaction with transcription coregulators, histone acetylases (CBP/SRC-1), and PGC-1alpha is crucial to FSH and TGFbeta1-up-regulated expression of Hsd3b and Cyp11a1, and, thus, progesterone production in rat ovarian granulosa cells. PMID: 18511507
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
  • 蛋白家族：
    3-beta-HSD family
  • 組織特異性：
    Expressed predominantly in male liver.
  • 數據庫鏈接：


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