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  4. Recombinant Rat 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (Plcb1), partial

Recombinant Rat 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (Plcb1), partial

  • 中文名稱：
    大鼠Plcb1重組蛋白
  • 貨號：
    CSB-YP018126RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Plcb1重組蛋白
  • 貨號：
    CSB-EP018126RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Plcb1重組蛋白
  • 貨號：
    CSB-EP018126RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Plcb1重組蛋白
  • 貨號：
    CSB-BP018126RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Plcb1重組蛋白
  • 貨號：
    CSB-MP018126RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; EC 3.1.4.11; PLC-154; Phosphoinositide phospholipase C-beta-1; Phospholipase C-I; PLC-I; Phospholipase C-beta-1; PLC-beta-1
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier.
  • 基因功能參考文獻：
    1. PLCbeta through its ability to bind TRAX plays a key role in switching PC12 cells to their differentiated state. PMID: 27624933
    2. Enhanced activation of protein kinase C delta (PKCdelta) in vascular smooth muscle cell (VSMC) from hypertensive rats (SHR) increases the expression of G alpha protein q (Gqalpha) and phospholipase C beta1 (PLCbeta1) proteins and results in VSMC hypertrophy. PMID: 27379421
    3. down-regulation of gamma-synuclein reduces the protein level of PLCbeta but increases the transcript level over 40 fold PMID: 26521046
    4. Enhanced oxidative stress in VSMCs from SHRs activates c-Src, growth factor receptors and MAPK signaling, contributing to enhanced expression of Gqalpha/PLCbeta1 proteins and VSMC hypertrophy. PMID: 26747500
    5. This study demonistrated that plc beta1 distribuate in rat cerebellum. PMID: 23503970
    6. Enhanced the expression of Gqalpha/PLC-beta1 proteins in vascular smooth muscle from 16-wk-old spontaneously hypertensive rats results in VSMC hypertrophy. PMID: 24760983
    7. These results provide a deeper knowledge of the cellular distribution of the PLCbeta1 isoform in different cell subtypes of the rat brain. PMID: 22735577
    8. These studies suggest that Protein kinase C phosphorylation regulates the level of Plcb1 cytosolic and nuclear activity by regulating its cellular compartmentalization. PMID: 21338571
    9. Studies show that TRAX, localized in the cytosol and nucleus, competes with plasma-membrane bound Galpha(q) for PLCbeta1 binding thus stabilizing PLCbeta1 in other cellular compartments. PMID: 21124736
    10. PLCbeta1b associates with a Shank3 complex at the cardiac sarcolemma via its splice-variant-specific C-terminal tail PMID: 21148417
    11. Levels of Galphaq, Galpha11, phospholipase C (PLC)-beta-1, and PLCbeta-2 proteins are significantly higher in vascular smooth muscle cells exposed to high glucose than in control cells, as determined by western blotting. PMID: 20393598
    12. reduced expression of protein kinase C alpha and phospholipase C beta(1) may be involved in the decreased insulin secretion by islets from low protein diet rats after stimulation with carbamylcholine and phorbol myristate acetate PMID: 12612139
    13. Up-regulation of nuclear PLCbeta1 during differentiation of a skeletal muscle cell line. PMID: 12704654
    14. phospholipase C-beta1 may account for the functional decline of subtype 5 metabotropic glutamate receptors in aging striatum PMID: 12786971
    15. findings suggested that expression levels of phospholipase c-beta1, delta1 and gamma1 isozymes are altered by hyperoxia and acrylonitrile, but there are apparent differences in these levels between the different levels of oxidative stress and organs PMID: 12850505
    16. Changes in PLC-beta 1a catalytic activity and subcellular distribution play important roles in neuronal signaling processes that are required for fear-conditioned learning and memory. PMID: 15159145
    17. These results indicate that the alpha-adrenoceptor mediated phospholipase C activation may be involved in the process of NE-induced cardiac hypertrophy. PMID: 15240149
    18. phospholipase-C beta1 (PLCbeta1) is predominantly expressed in the neurons of the granular layer, while it is virtually absent in the molecular and Purkinje cell layers of rat cerebellar cortex PMID: 15254758
    19. Repeated inescapable shock decreased the expression of PLC beta1 and PLC gamma1 isozymes in the brain. PMID: 15536495
    20. findings demonstrated that G-protein-activated phospholipase C-beta interacts with cell polarity proteins Par3 and Par6 to form protein complexes and to mediate downstream signal transduction PMID: 15782111
    21. Homodimerization of PLC-beta3 and PLC-beta1 isoenzymes was observed but heterodimerization of these isoenzymes was not detected. PMID: 16763092
    22. activation of PLC is a vital step in the neuronal protective adenosine-induced signal transduction pathway PMID: 17065107
    23. Deletion of 3 amino acids from the C terminus of PLCbeta1b did not alter its sarcolemmal localization, but deletion of the entire unique 31 amino acid sequence caused cytosolic localization. PMID: 18390926
    24. Ins(1,4,5)P(3) and IP(3)-receptor (type 2) regulate PLCbeta1 and thereby maintain levels of Ins(1,4,5)P(3), which implies some functional significance for Ins(1,4,5)P(3) in the heart PMID: 18692062
    25. These results hint at the fact that PLC-beta(1) catalytic activity signals a c-jun/AP-1 target gene, i.e. cyclin D3, during myogenic differentiation. PMID: 18694821
    26. High glucose increases the expression of Gq/11alpha and PLC-beta proteins and associated signaling in vascular smooth muscle cells. PMID: 18820027
    27. hypertrophic responses initiated by Gq are mediated specifically by PLCbeta1b. PMID: 19564249

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  • 亞細胞定位：
    Nucleus membrane. Cytoplasm.
  • 組織特異性：
    Highest expression in brain. Also expressed in parotid gland, liver, uterus, lung, heart, adrenal gland and ovary. Not detected in spleen, pancreas, intestine, thymus or kidney.
  • 數據庫鏈接：


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