在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rabbit Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1), partial

Recombinant Rabbit Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1), partial

  • 中文名稱：
    Recombinant Rabbit Sarcoplasmic/endoplasmic reticulum calcium ATPase 1(ATP2A1) ,partial
  • 貨號：
    CSB-YP002332RB
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rabbit Sarcoplasmic/endoplasmic reticulum calcium ATPase 1(ATP2A1) ,partial
  • 貨號：
    CSB-EP002332RB
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rabbit Sarcoplasmic/endoplasmic reticulum calcium ATPase 1(ATP2A1) ,partial
  • 貨號：
    CSB-EP002332RB-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rabbit Sarcoplasmic/endoplasmic reticulum calcium ATPase 1(ATP2A1) ,partial
  • 貨號：
    CSB-BP002332RB
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rabbit Sarcoplasmic/endoplasmic reticulum calcium ATPase 1(ATP2A1) ,partial
  • 貨號：
    CSB-MP002332RB
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    ATP2A1Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; SERCA1; SR Ca(2+)-ATPase 1; EC 7.2.2.10; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type; fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase
  • 種屬：
    Oryctolagus cuniculus (Rabbit)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
  • 基因功能參考文獻：
    1. the major SR membrane lipid PC is optimal for all steps and, unlike the other headgroups, contributes favorable electrostatics and non-electrostatic elements during the Ca-ATPase transition PMID: 29032359
    2. ATP-dependent Ca(2+) transport by SERCA in single giant unilamellar vesicles was detected directly using confocal fluorescence microscopy. PMID: 27815070
    3. Glycine 105 as Pivot for a Critical Knee-like Joint between Cytoplasmic and Transmembrane Segments of the Second Transmembrane Helix in Ca2+-ATPase.( PMID: 27733680
    4. Here we describe the methods to analyze these processes in the transport cycle with a representative member of P-type ATPase family, SERCA1a, sarco(endo)plasmic reticulum Ca(2+)-ATPase PMID: 26695035
    5. oligonucleotide-based drugs could be used to fine-tune SERCA function to counterbalance the extent of the pathological insults. PMID: 26292938
    6. Inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA1) by rutin derivatives. PMID: 25467059
    7. Infrared spectroscopy was used to characterise recombinant sarcoplasmic reticulum Ca2+-ATPase (SERCA1a). PMID: 24965041
    8. Data show that biselyngbyasides (BLSs) bind to the pump SERCA1a calcium ATPase near the cytoplasmic surface of the transmembrane region. PMID: 25957767
    9. Cell functions regulated by protein-protein interactions of the SERCA1a-sarcolipin complex is accomplished via s-palmitoylation and s-oleoylation of sarcolipin. PMID: 25301946
    10. Rescue of mutated SERCA1 to sarcoplasmic reticulum membrane can re-establish resting cytosolic Ca(2+) concentration and prevent the appearance of pathological signs of cattle pseudomyotonia PMID: 25288803
    11. Conformation of the SERCA1A calcium ATPase in the presence of different lipids. PMID: 25103814
    12. Ca(2+) and PLB phosphorylation relieve SERCA-PLB inhibition by distinct mechanisms, but both are achieved primarily by structural changes within the SERCA-PLB complex, not by dissociation of that complex. PMID: 24813991
    13. Phosphorylated phospholamban stabilizes a unique conformation of SERCA that is characterized by a compact architecture. PMID: 24138857
    14. Data suggest some phytoestrogenic flavonoids cooperate to inhibit SERCA, alter ATP binding properties of SERCA, and alter phosphorylation/dephosphorylation of SERCA by binding to several sites that are close to ATP binding site. PMID: 24238016
    15. Data suggest that phospholamban PLN's conformational equilibrium is central to maintain sarcoplasmic reticulum Ca(2+)-ATPase SERCA's apparent Ca(2+) affinity within a physiological window. PMID: 24101520
    16. Data suggest that the long-range electrostatics likely guide N and P domain motions in SERCA1a calcium ATPase. PMID: 23737524
    17. Sarcoplasmic reticulum Ca(2+) uptake by SERCA is an integral part of the mechanism by which spontaneous Ca(2+) waves propagate through cardiac myocytes. PMID: 22988145
    18. crystal structure of native SERCA1a (from rabbit) in this E1.Mg(2+) state at 3.0 A resolution in addition to crystal structures of SERCA1a in E2 free from exogenous inhibitors PMID: 23455422
    19. crystal structure of rabbit SERCA1a (also known as ATP2A1) in complex with sarcolipin at 3.1 A resolution PMID: 23455424
    20. CS and SERCA activities were significantly higher in the pubococcygeus (Pc) compared with the ischiocavernosus/bulbospongiosus (Ic/Bs) pelvic floor muscles, whereas the ChAT activity of the Ic/Bs was higher than that of the Pc muscle. PMID: 22911511
    21. On the basis of extended MD simulations with 8 combinations of protonation states of 4 acidic residues in the Ca2+ ion binding sites, data indicate 3 bound protons are sufficient to ensure a stable binding pocket in SERCA. PMID: 22082179
    22. The lipid bilayer composition influences the regulation of SERCA by PLN. PMID: 21992175
    23. Investigations visualize conformational changes in SERCA (in sarcoplasmic reticulum) in real time at single-molecule level. Data suggest catalytic pathway of SERCA is different from the ordinary Albers-Post scheme under physiological conditions. PMID: 21707923
    24. Curcumin could improve cardiac function via upregulating the expression of sarcoplasmic reticulum Ca2+-ATPase. PMID: 20654087
    25. the effects of substitution mutations on the isolated SERCA1a-nucleotide binding domain (SERCA-N) were studied using NMR. PMID: 21187073
    26. Phosphorylation of PLB induces spatial rearrangements between the N- and P-domain elements of proximal Ca-ATPase. PMID: 19191503
    27. Digestion with proteinase K or trypsin yields complementary information on conformational transitions of the Ca(2+)-ATPase (SERCA) in the native membrane environment PMID: 17993458

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIA subfamily
  • 組織特異性：
    Skeletal muscle (at protein level). Skeletal muscle, fast twitch muscle (type II) fibers.
  • 數據庫鏈接：


主站蜘蛛池模板： 日本xxxx色视频在线观看| 在线播放亚洲第一字幕| 国产精品无码一区二区三区 | 四虎永久在线高清国产精品| 国产xxx视频在线观看软件| 国产av一区二区精品久久凹凸| 国产伦理一区二区| 亚欧无线一线二线三线区别| 天堂在线www资源在线| 国产精品久久久久影院色| 色欲色香天天天综合网www| 99久久精品无码一区二区毛片| 巨熟乳波霸若妻在线播放| 欧美日韩国产综合新一区| 国产一区二区三区久久精品| 中国国产野外1级毛片视频| 日本高清中文字幕免费一区二区 | a毛片免费全部播放自慰| 国产性色播播毛片| 日本成aⅴ人片日本伦| 成人无码视频在线观看大全| 久久99av无色码人妻蜜| 1000部夫妻午夜免费| 女人的精水喷出来视频| 久久99亚洲含羞草影院| 中文在线天堂а√在线| 少妇性饥渴无码a区免费| 最新高清中文字幕免费mv| 亚洲国产成人在人网站天堂| 国产乱色国产精品播放视频| 久久久免费精品re6| 国产精品乱子伦xxxx| 亚洲 欧美 唯美 国产 伦 综合 | 欧美精品videossex少妇| 久久久久久人妻一区二区三区| 国产亚洲福利在线视频| 成人亚洲欧美激情在线电影| 国产午夜精品一区理论片飘花| 久久tv中文字幕首页| 国产色情又大又粗又黄的电影| 免费人成自慰网站|