在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rabbit Ribosomal protein S6 kinase beta-1 (RPS6KB1), partial

  • 中文名稱:
    小圓錐花果RPS6KB1重組蛋白
  • 貨號:
    CSB-YP020470RB
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小圓錐花果RPS6KB1重組蛋白
  • 貨號:
    CSB-EP020470RB
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    小圓錐花果RPS6KB1重組蛋白
  • 貨號:
    CSB-EP020470RB-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小圓錐花果RPS6KB1重組蛋白
  • 貨號:
    CSB-BP020470RB
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小圓錐花果RPS6KB1重組蛋白
  • 貨號:
    CSB-MP020470RB
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    RPS6KB1Ribosomal protein S6 kinase beta-1; S6K-beta-1; S6K1; EC 2.7.11.1; 70 kDa ribosomal protein S6 kinase 1; P70S6K1; p70-S6K 1; Ribosomal protein S6 kinase I; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6K-alpha; p70 S6KA
  • 種屬:
    Oryctolagus cuniculus (Rabbit)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin. Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR. Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition.
  • 亞細胞定位:
    Cytoplasm. Cell junction, synapse, synaptosome. Mitochondrion outer membrane. Mitochondrion.
  • 蛋白家族:
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
  • 數據庫鏈接:


主站蜘蛛池模板: 波多野结衣人妻| 伊人色综合九久久天天蜜桃| 巨大巨粗巨长 黑人长吊| 亚洲 小说区 图片区 都市| 韩国精品一区二区三区无码视频| 久久亚洲道色宗和久久| 最近中文字幕mv在线视频2018| 国产人妻人伦精品| 国产成人人人97超碰超爽8| 无码av免费一区二区三区a片| 国产日韩在线观看不卡顿| 欧美日韩综合一区二区三区| 日本一二三区视频在线| 国产成人乱色伦区| 中文无码精品a∨在线| 日日噜噜噜噜夜夜爽亚洲精品| 黑人巨茎大战俄罗斯美女| 亚洲日韩在线中文字幕综合| 亚洲国产桃花岛一区二区| www一区二区www免费| 欧美精品中文字幕亚洲专区| 色视频无码专区在线观看| 亚洲人成人无码www影院| 天天拍天天看天天做| 天天天天做夜夜夜夜做无码| 亚洲欧洲日产国码无码网站| 精品丰满人妻无套内射| 中文www新版资源在线| 侵犯强奷高清无码| 都市激综合小说区另类区| 精品影片在线观看的网站| 亚洲欧美色αv在线影视| 体内射精日本视频免费看| 午夜天堂av天堂久久久| 欧美午夜理伦三级在线观看| 黑人强伦姧人妻久久| 日日噜狠狠噜天天噜av| 富婆如狼似虎找黑人老外| 欧美日韓性视頻在線| 浓毛欧美老妇乱子伦视频| 免费人成在线观看视频播放|