Recombinant Rabbit Caspase-3 (CASP3)

中文名稱：

Recombinant Rabbit Caspase-3(CASP3)
貨號：

CSB-YP853987RB
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Rabbit Caspase-3(CASP3)
貨號：

CSB-EP853987RB
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Rabbit Caspase-3(CASP3)
貨號：

CSB-EP853987RB-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Rabbit Caspase-3(CASP3)
貨號：

CSB-BP853987RB
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Rabbit Caspase-3(CASP3)
貨號：

CSB-MP853987RB
規(guī)格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

CASP3
Uniprot No.：

Q8MJC3
別名：

CASP3Caspase-3; CASP-3; EC 3.4.22.56; Apopain; Cysteine protease CPP32) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
種屬：

Oryctolagus cuniculus (Rabbit)
蛋白長度：

Full Length of Mature Protein
表達區(qū)域：

29-175
氨基酸序列

SG KYLDNSYKMD YPEMGLCIII NNKNFHKNTG MSSRSGTDVN AANLGETFMN LKYEVRNKND LTREEIMELM YNVSKEDHSK RSSFICVILS HGDEGVIYGT NGPIELKKLT SFFRGDYCRS LTGKPKLFII QACRGTELDS GIETD
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage. Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface.
基因功能參考文獻：
1. excessive apoptosis does occur in acetabular cartilage with developmental dislocations of the hip, and is positively correlated with high caspase-3 expression as well as low Bcl-2 expression. PMID: 27706761
2. This study revealed that the 810-nm low-level laser can improve cartilage structure, prevent articular cartilage degradation and significantly decrease the expression of caspase-3 in this surgery-induced osteoarthritis model. PMID: 21188382
3. Morphine hypoxic preconditioning can protect rabbits against acute kidney hypoxic/reoxygenation injury by decreasing expression of caspase-3. PMID: 21774217
4. Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 and down-regulating the activation of caspase-3. PMID: 20448357
5. High frequency oscillatory ventilation combined with exogenous pulmonary surfactant can decrease the concentration of caspase-3 and p73 rabbit with acute respiratory failure. PMID: 18549708
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亞細胞定位：

Cytoplasm.
蛋白家族：

Peptidase C14A family
數據庫鏈接：

KEGG: ocu:100008840

STRING: 9986.ENSOCUP00000005723

UniGene: Ocu.2659