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  4. Recombinant Probable Werner syndrome ATP-dependent helicase homolog 1 (wrn-1), partial

Recombinant Probable Werner syndrome ATP-dependent helicase homolog 1 (wrn-1), partial

  • 中文名稱：
    秀麗隱桿線蟲wrn-1重組蛋白
  • 貨號：
    CSB-YP623291CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲wrn-1重組蛋白
  • 貨號：
    CSB-EP623291CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲wrn-1重組蛋白
  • 貨號：
    CSB-EP623291CXY-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲wrn-1重組蛋白
  • 貨號：
    CSB-BP623291CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲wrn-1重組蛋白
  • 貨號：
    CSB-MP623291CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    wrn-1
  • Uniprot No.：
  • 別名：
    wrn-1; F18C5.2; Probable Werner syndrome ATP-dependent helicase homolog 1; EC 3.6.4.12
  • 種屬：
    Caenorhabditis elegans
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability.
  • 基因功能參考文獻(xiàn)：
    1. WRN-1 plays a conserved role in the resection of DSB ends and mediates checkpoint signaling, thereby influencing levels of RPA and RAD-51 PMID: 28640365
    2. WRN-1 functions downstream of RPA-1 and upstream of CHK-1 in the DSB checkpoint pathway and is also required for the repair of DSB. PMID: 26691982
    3. analysis of physical and functional interactions of Caenorhabditis elegans WRN-1 helicase with RPA-1 PMID: 22257160
    4. WRN-1 functions together with RPA-1 upstream of ATM and ATR to trigger cell cycle arrest in response to double-strand DNA breaks. PMID: 20062519
    5. WRN-1 acts as a checkpoint protein for DNA damage and replication blockage. PMID: 15115755
    6. This protein is able to unwind DNA structures may improve the access for DNA repair and replication proteins that are important for preventing the accumulation of abnormal structures. PMID: 18558712

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Helicase family, RecQ subfamily
  • 數(shù)據(jù)庫鏈接：

    KEGG: cel:CELE_F18C5.2

    STRING: 6239.F18C5.2

    UniGene: Cel.7245



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