在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Pongo abelii Pumilio homolog 1 (PUM1), partial

Recombinant Pongo abelii Pumilio homolog 1 (PUM1), partial

  • 中文名稱：
    波戈阿貝利PUM1重組蛋白
  • 貨號：
    CSB-YP728915PYX
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    波戈阿貝利PUM1重組蛋白
  • 貨號：
    CSB-EP728915PYX
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    波戈阿貝利PUM1重組蛋白
  • 貨號：
    CSB-EP728915PYX-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    波戈阿貝利PUM1重組蛋白
  • 貨號：
    CSB-BP728915PYX
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    波戈阿貝利PUM1重組蛋白
  • 貨號：
    CSB-MP728915PYX
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    PUM1; Pumilio homolog 1
  • 種屬：
    Pongo abelii (Sumatran orangutan)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle. Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation. Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm. Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery. Plays a role in cytoplasmic sensing of viral infection. In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation. Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level.
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, P-body. Cytoplasmic granule.
  • 數據庫鏈接：


主站蜘蛛池模板： 熟女丝袜潮喷内裤视频网站| 熟妇人妻午夜寂寞影院| 无码任你躁久久久久久老妇| 正在播放国产真实哭都没用| 成年无码av片在线免缓冲| 少妇无码av无码去区钱| 成人片黄网站色大片免费毛片| 日本熟妇色xxxxx日本免费看 | 成人无遮挡裸免费视频在线观看| 精品国产乱码久久久久久口爆 | 国产人妻人伦精品| 国产成人精品三上悠亚| 在线播放十八禁视频无遮挡| 亚洲中文字幕无码卡通动漫野外 | 午夜成人鲁丝片午夜精品| 影音先锋在线资源无码| 四虎影视无码永久免费| 日本熟妇色xxxxx欧美老妇| 精品国产污污免费网站入口| 国产精品永久免费视频| 欧美99久久无码一区人妻a片| 国产丰满人妻一区二区 | 亚洲精品无码ma在线观看| 中文字幕精品亚洲无线码二区| 中文字幕亚洲乱码熟女在线| 精产国品一二三产区9977| 青青热久免费精品视频| 五月丁香啪啪| 高潮毛片无遮挡高清视频播放| 四虎成人永久在线精品免费| 伊人精品无码av一区二区三区 | 99精品无人区乱码在线观看| 在线高清理伦片a| 亚洲a∨精品一区二区三区| 亚欧免费无码aⅴ在线观看| 精品www日韩熟女人妻| 日日橹狠狠爱欧美视频| 免费的污污的网站在线观看| 国产一区二区三区乱码在线观看| 成人免费b2b网站大全在线| 久久成人伊人欧洲精品|