在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Pig TGF-beta receptor type-1 (TGFBR1), partial

  • 中文名稱:
    野豬TGFBR1重組蛋白
  • 貨號:
    CSB-YP685610PI
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    野豬TGFBR1重組蛋白
  • 貨號:
    CSB-EP685610PI
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    野豬TGFBR1重組蛋白
  • 貨號:
    CSB-EP685610PI-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    野豬TGFBR1重組蛋白
  • 貨號:
    CSB-BP685610PI
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    野豬TGFBR1重組蛋白
  • 貨號:
    CSB-MP685610PI
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    TGFBR1; TGF-beta receptor type-1; TGFR-1; EC 2.7.11.30; TGF-beta type I receptor; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TbetaR-I
  • 種屬:
    Sus scrofa (Pig)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.
  • 基因功能參考文獻:
    1. miR-181a promoted porcine preadipocyte differentiation by directly targeting TGFBR1. PMID: 30266501
    2. The results indicate that the TGFBR1 gene polymorphism (SNP64) is significantly associated with growth rates including average daily gains between birth and 56 kg, between 5.5 and 56 kg, between 35 and 56 kg. PMID: 22292700
    3. Report temporal regulation of TGFBR1 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig. PMID: 19359354
    4. TGFbeta is abundant in boar seminal plasma, thus TGFbeta may be a male-female signalling agent involved in immune changes in the female reproductive tract elicited by seminal fluid. PMID: 21791176
    5. Porcine transforming growth factor beta receptor 1 has many polymorphisms, including two nonsynonymous substitutions in exons 1 and 7 and novel alternative splicing in exon 3. PMID: 16341765
    6. isolation and molecular characterization; the full-length TGFBR1 cDNA 1813 bp contains an open reading frame (ORF) of 1512 bp encoding a TGFBR1 protein of 503 amino acids with a calculated molecular weight of 56.4 kDa. PMID: 16950575

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Membrane raft. Cell surface.
  • 蛋白家族:
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
  • 數據庫鏈接:


主站蜘蛛池模板: 亚洲熟女综合色一区二区三区| 国内精品乱码卡一卡2卡三卡新区 亚洲爆乳成av人在线视菜奈实 | 中文天堂最新版资源www官网| 欧美寡妇xxxx黑人猛交| 伊人久久大香线蕉av网| 色窝窝免费一区二区三区| 精品无码无人网站免费视频| 国产精品无码专区av在线播放| 亚洲精品国产精华液有哪些| 无码av片在线观看免费| 露脸内射熟女--69xx| 少妇熟女高潮流白浆| 7878成人国产在线观看| 性色av一二三天美传媒| 日本人与黑人做爰视频网站| 精品人妻码一区二区三区| 色一情一伦一区二区三| 人人爽人人澡人人人人妻| 午夜大片免费男女爽爽影院| 日韩免费无码一区二区视频| 日本道免费精品一区二区| 狠狠色丁香久久婷婷综合蜜芽五月| 成人毛片100部免费看| 与子敌伦刺激对白播放的优点| 久久国产免费福利永久| 欧美性白人极品1819hd| 国产一区二区三区久久精品| 色综合天天视频在线观看| 丰满的少妇邻居中文bd| 无码免费一区二区三区| 无码人妻一区二区三区免费| 国产激情无码一区二区app| av无码免费岛国动作片不卡| 久久无码人妻精品一区二区三区| 四虎亚洲欧美成人网站| 亚洲精品中文字幕久久久久下载| 中文字幕av无码一区二区三区电影| 麻豆国产97在线 | 欧美| 国产一区二区三区在线电影| 四虎精品成人a在线观看| 国产熟妇高潮叫床视频播放|