在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Pig Interleukin-10 (IL10)

Recombinant Pig Interleukin-10 (IL10)

  • 中文名稱：
    野豬IL10重組蛋白
  • 貨號：
    CSB-YP640888PI
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    野豬IL10重組蛋白
  • 貨號：
    CSB-EP640888PI
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    野豬IL10重組蛋白
  • 貨號：
    CSB-EP640888PI-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    野豬IL10重組蛋白
  • 貨號：
    CSB-BP640888PI
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    野豬IL10重組蛋白
  • 貨號：
    CSB-MP640888PI
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    IL10Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF
  • 種屬：
    Sus scrofa (Pig)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    19-175
  • 氨基酸序列
    SI KSENSCIHFP TSLPHMLREL RAAFGPVKSF FQTKDQMGDL LLTGSLLEDF KGYLGCQALS EMIQFYLEDV MPKAESDGED IKEHVNSLGE KLKTLRLRLR RCHQFLPCEN KSKAVEEVKS AFSKLQERGV YKAMGEFDIF INYIEAYMTM KMRKN
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling.
  • 基因功能參考文獻：
    1. The PRRSV vaccination induced higher levels of IL-10 expression in the first week and this may be why the CSFV vaccination is immunosuppressed. PMID: 27938685
    2. These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity. PMID: 25614594
    3. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10, and IL-6 in ovarian follicles are reported. PMID: 24020676
    4. Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma+CD4+ regulatory T cells to control transplant arteriosclerosis. PMID: 23359497
    5. Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK activation. PMID: 22909062
    6. Boar seminal plasma contained TGF- beta1 and IL-10 but with high individual variation. PMID: 22482797
    7. Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model. PMID: 20163907
    8. These results suggest that TNF-alpha and IL-10, but not IL-6, are involved in the late reparatory phases of the experimental disk lesion. PMID: 19605905
    9. The present study shows that elevated levels of serum CRP and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome) PMID: 16817761
    10. Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio. PMID: 17592737
    11. Twenty one polymorphisms in the IL10 gene have been found, including single nucleotide polymorphisms and insertion deletion polymorphisms. The chromosomal location has been mapped by FISH and radiation hybrid mapping. PMID: 18607788
    12. findings show that Brachyspira hyodysenteriae inoculation induced production of systemic levels of IL-1beta during the dysentery period and increased levels of IL-10 coincided with recovery from dysentery PMID: 18700003

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    IL-10 family
  • 數據庫鏈接：


主站蜘蛛池模板： 一二三四观看视频社区在线| 久久久久免费看成人影片| 人妻av中文系列| 成人做受120秒试看试看视频| 东京热一精品无码av| 欧美成人精品第一区二区三区| 亚洲情a成黄在线观看| 国产av一区二区三区无码野战| 久久伊人色av天堂九九| 国产人碰人摸人爱免费视频| 国产欧美在线亚洲一区| 日日躁狠狠躁狠狠爱| 激情内射人妻1区2区3区| 麻豆一区二区99久久久久| 美女扒开腿让男人桶爽揉| 最新高清中文字幕免费mv| 欧美精品久久久久久久自慰| 国产女人18毛片水真多18精品| 一本清日本在线视频精品| 国色精品卡一卡2卡3卡4卡在线 | 中文字日产幕乱五区| 轻点好疼好大好爽视频| 真实国产乱子伦对白在线播放| 四虎成人欧美精品在永久在线| 亚洲一区二区三区无码久久| 久久精品国产免费观看| 377人体粉嫩噜噜噜| 精品无码国产日韩制服丝袜| 亚洲中文字幕码在线电影| 中文无码熟妇人妻av在线| 波多野结av衣东京热无码专区| 草草浮力地址线路①屁屁影院| 国产精品国产午夜免费看福利| 无码国产精品一区二区免费vr| 色综合久久中文综合网| 亚洲国产区男人本色| 亚洲成a∧人片在线播放调教| 激情97综合亚洲色婷婷五| a∨变态另类天堂无码专区| 国产丰满老熟女重口对白| 欧美特级特黄aaaaaa在线看|