在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Pig Interleukin-10 (IL10)

Recombinant Pig Interleukin-10 (IL10)

  • 中文名稱：
    野豬IL10重組蛋白
  • 貨號：
    CSB-YP640888PI
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    野豬IL10重組蛋白
  • 貨號：
    CSB-EP640888PI
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    野豬IL10重組蛋白
  • 貨號：
    CSB-EP640888PI-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    野豬IL10重組蛋白
  • 貨號：
    CSB-BP640888PI
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    野豬IL10重組蛋白
  • 貨號：
    CSB-MP640888PI
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    IL10Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF
  • 種屬：
    Sus scrofa (Pig)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    19-175
  • 氨基酸序列
    SI KSENSCIHFP TSLPHMLREL RAAFGPVKSF FQTKDQMGDL LLTGSLLEDF KGYLGCQALS EMIQFYLEDV MPKAESDGED IKEHVNSLGE KLKTLRLRLR RCHQFLPCEN KSKAVEEVKS AFSKLQERGV YKAMGEFDIF INYIEAYMTM KMRKN
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling.
  • 基因功能參考文獻：
    1. The PRRSV vaccination induced higher levels of IL-10 expression in the first week and this may be why the CSFV vaccination is immunosuppressed. PMID: 27938685
    2. These data indicate that the type 2 porcine reproductive and respiratory syndrome virus N protein plays an important role in IL-10 induction and the N-N non-covalent domain is associated with this activity. PMID: 25614594
    3. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10, and IL-6 in ovarian follicles are reported. PMID: 24020676
    4. Prostaglandin E2 potentiates mesenchymal stem cell-induced IL-10+IFN-gamma+CD4+ regulatory T cells to control transplant arteriosclerosis. PMID: 23359497
    5. Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK activation. PMID: 22909062
    6. Boar seminal plasma contained TGF- beta1 and IL-10 but with high individual variation. PMID: 22482797
    7. Changes in interleukin-10 mRNA expression are predictive for 9-day survival of pigs in an emergency preservation and resuscitation model. PMID: 20163907
    8. These results suggest that TNF-alpha and IL-10, but not IL-6, are involved in the late reparatory phases of the experimental disk lesion. PMID: 19605905
    9. The present study shows that elevated levels of serum CRP and IL-10 were associated with porcine circovirus type 2-infected piglets that subsequently developed severe PMWS.(postweaning multisystemic wasting syndrome) PMID: 16817761
    10. Subclinically porcine circovirus type 2 (PCV2)-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio. PMID: 17592737
    11. Twenty one polymorphisms in the IL10 gene have been found, including single nucleotide polymorphisms and insertion deletion polymorphisms. The chromosomal location has been mapped by FISH and radiation hybrid mapping. PMID: 18607788
    12. findings show that Brachyspira hyodysenteriae inoculation induced production of systemic levels of IL-1beta during the dysentery period and increased levels of IL-10 coincided with recovery from dysentery PMID: 18700003

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    IL-10 family
  • 數據庫鏈接：


主站蜘蛛池模板： 国产日韩欧美亚欧在线观看| 色午夜一av男人的天堂| 精品少妇ay一区二区三区| 18禁黄网站禁片免费观看国产| 日本wv一本一道久久香蕉| 久久久久久久久久久综合日本| 亚洲爆乳大丰满无码专区| 九九视频国产免| 色综合欧美五月俺也去| 精品国模一区二区三区| 亚洲欧美日韩国产成人精品影院 | 国产精品高清视亚洲中文| 精产国品一二三产区9977 | 老司机亚洲精品影院| 内射人妻无套中出无码| 寂寞人妻瑜伽被教练日| 大伊香蕉精品视频在线| 亚洲三区在线观看无套内射| 四虎永久在线高清国产精品| 国产精品久人妻精品老妇| 久久人人爽人人爽人人片av高清 | 国产女人精品视频国产灰线| 亚欧成人中文字幕一区| 国产又黄又爽又色的免费视频| 精品人妻无码专区在线无广告视频| 国产美女视频免费观看的网站| 国产亚洲精品自在久久vr| 99国产精品无码| 欧美性猛交xxxx免费视频软件| 欧洲vat一区二区三区| 精品国产一区二区av麻豆| 最新高清无码专区| 国内揄拍国产精品人妻门事件 | 国产成人无码aa精品一区| 国产成人精品综合久久久久| 久久精品成人欧美大片| 男女啪啪永久免费网站| 日本伊人色综合网| 国产精品 亚洲一区二区三区| 国产高清在线精品一区免费| 中文字幕乱码免费看电影|