在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Pig Interferon regulatory factor 1 (IRF1)

  • 中文名稱:
    野豬IRF1重組蛋白
  • 貨號:
    CSB-YP011814PI
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    野豬IRF1重組蛋白
  • 貨號:
    CSB-EP011814PI
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    野豬IRF1重組蛋白
  • 貨號:
    CSB-EP011814PI-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    野豬IRF1重組蛋白
  • 貨號:
    CSB-BP011814PI
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    野豬IRF1重組蛋白
  • 貨號:
    CSB-MP011814PI
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    IRF1Interferon regulatory factor 1; IRF-1
  • 種屬:
    Sus scrofa (Pig)
  • 蛋白長度:
    Full length protein
  • 表達區(qū)域:
    1-322
  • 氨基酸序列
    MPITRMRMRP WLEMQINSNQ IPGLIWINKE EMIFQIPWKH AAKHGWDINK DACLFRSWAI HTGRYKAGEK EPDPKTWKAN FRCAMNSLPD IEEVKDQSRN KGSSAVRVYR MLPPLTKNQR KERKSKSSRD AKCKAKKKSC GESSPDTFSD GLSSSTLPDD HSSYTAQGYI GQDLDIEQAL TPALSPCAIS STLPEWRIPV EIVPDSTSDL YNFQVSPMPS TSEAATDEDE EGKLTEDIMK LLEQSGWQQT NVDGKGYLLN EPGAQPTAVY GDFSCKEEPE VESPGGYTGL ISSDLKNVDT SWLDNLLTPV RLPSIQAIPC AP
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Binds to a consensus sequence in gene promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.
  • 基因功能參考文獻:
    1. As an innate immune response protein with broad-spectrum antiviral activity, the up-regulation of ISG15 mediated by IRF1 in porcine cells is reported for the first time. These results warrant further investigation into the antiviral activity of porcine IRF1 against reported swine viruses. PMID: 29324236
    2. Given these results, porcine IRF1 plays potential roles in cellular antiviral responses against swine viruses. PMID: 26593937
    3. In a healthy swine model, elevated levels of endothelial IRF-1 were also observed within atherosusceptible regions of the aorta by Western blot analysis and immunohistochemistry, implicating arterial hemodynamics in the regulation of IRF-1 expression. PMID: 23934855
    4. The results suggested that the porcine IRF1 gene is strong candidate gene for these immune traits in pig. PMID: 20853146
  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    IRF family
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 国产成人亚洲精品另类动态 | 国产成人8x人网站视频在线观看| 亚洲午夜福利院在线观看 | 国产成人精品亚洲午夜麻豆| 8av国产精品爽爽ⅴa在线观看| 国产极品白嫩精品| 亚洲高潮喷水无码av电影| 久久99亚洲精品久久频| 影音先锋无码aⅴ男人资源站| 日韩不卡手机视频在线观看| 久久久774这里只有精品17| 亚洲图片综合图区20p| 亚洲18禁私人影院| 国产午夜大地久久| 亚洲日本中文字幕乱码在线| 双乳奶水饱满少妇呻吟| 女子spa高潮呻吟抽搐| 日韩人妻熟女中文字幕aⅴ春菜| 国产超碰人人做人人爱一二区视品| 18禁黄网站男男禁片免费观看| 久久人人爽人人爽人人片亞洲| 亚洲中文字幕丝祙制服| 国产成人高清亚洲一区妲妃| 丰满少妇熟乱xxxxx视频| 五十老熟妇乱子伦免费观看| 精品国产一二三产品区别在哪 | 男人j进女人p免费视频| 无码人妻一区二区三区在线视频| 国产精品国语对白露脸在线播放| 少妇高潮太爽了在线观看欧美| 欧美亚洲国产一区二区三区| 亚洲人成人无码网www国产| 黑人强伦姧人妻久久| 亚洲欧美乱综合图片区小说区| 无码免费毛片手机在线无卡顿 | 国产亚洲精品久久久久久入口| 久久久免费无码成人影片| 午夜成人理论福利片| 国产国产久热这里只有精品| 东京热人妻丝袜av无码| 国产人妻一区二区三区久|