在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Pig Interferon regulatory factor 1 (IRF1)

Recombinant Pig Interferon regulatory factor 1 (IRF1)

  • 中文名稱：
    野豬IRF1重組蛋白
  • 貨號：
    CSB-YP011814PI
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    野豬IRF1重組蛋白
  • 貨號：
    CSB-EP011814PI
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    野豬IRF1重組蛋白
  • 貨號：
    CSB-EP011814PI-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    野豬IRF1重組蛋白
  • 貨號：
    CSB-BP011814PI
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    野豬IRF1重組蛋白
  • 貨號：
    CSB-MP011814PI
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    IRF1Interferon regulatory factor 1; IRF-1
  • 種屬：
    Sus scrofa (Pig)
  • 蛋白長度：
    Full length protein
  • 表達區(qū)域：
    1-322
  • 氨基酸序列
    MPITRMRMRP WLEMQINSNQ IPGLIWINKE EMIFQIPWKH AAKHGWDINK DACLFRSWAI HTGRYKAGEK EPDPKTWKAN FRCAMNSLPD IEEVKDQSRN KGSSAVRVYR MLPPLTKNQR KERKSKSSRD AKCKAKKKSC GESSPDTFSD GLSSSTLPDD HSSYTAQGYI GQDLDIEQAL TPALSPCAIS STLPEWRIPV EIVPDSTSDL YNFQVSPMPS TSEAATDEDE EGKLTEDIMK LLEQSGWQQT NVDGKGYLLN EPGAQPTAVY GDFSCKEEPE VESPGGYTGL ISSDLKNVDT SWLDNLLTPV RLPSIQAIPC AP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Binds to a consensus sequence in gene promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.
  • 基因功能參考文獻：
    1. As an innate immune response protein with broad-spectrum antiviral activity, the up-regulation of ISG15 mediated by IRF1 in porcine cells is reported for the first time. These results warrant further investigation into the antiviral activity of porcine IRF1 against reported swine viruses. PMID: 29324236
    2. Given these results, porcine IRF1 plays potential roles in cellular antiviral responses against swine viruses. PMID: 26593937
    3. In a healthy swine model, elevated levels of endothelial IRF-1 were also observed within atherosusceptible regions of the aorta by Western blot analysis and immunohistochemistry, implicating arterial hemodynamics in the regulation of IRF-1 expression. PMID: 23934855
    4. The results suggested that the porcine IRF1 gene is strong candidate gene for these immune traits in pig. PMID: 20853146
  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    IRF family
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 亚洲综合小说专区图片| 女人下边被添全过视频| 中国少妇内射xxxx狠干| 青草青草久热精品视频在线观看| av无码久久久久久不卡网站| 免费裸体黄网站18禁免费 | 亚洲成a人片在线观看你懂的| 亚洲精品国产suv一区88| 精品国产精品三级精品av网址| 国产日韩欧美久久久精品图片| 九九热久久只有精品2| 欧美群妇大交群| 国产人妖xxxx做受视频| 久久久久久久久免费看无码| 免费无遮挡很爽很污很黄的网站| 日本xxxxx片免费观看喷水| 超碰国产精品久久国产精品99 | 高清不卡毛片免费观看| 国产制服日韩丝袜86页| 亚洲va成无码人在线观看天堂| 精品国产aⅴ无码一区二区| 欧美真人性野外做爰| 国产精品女主播主要上线| 日本乱人伦aⅴ精品| 国产亚洲精品字幕在线观看| 国产精品岛国久久久久| 免费无码av片在线观看潮喷| 亚洲a∨精品一区二区三区| 青青青国产精品一区二区| 强开小婷嫩苞又嫩又紧视频韩国| 狠狠躁夜夜躁无码中文字幕| 免费乱码人妻系列无码专区| 亚洲一区精品二人人爽久久| 无码h肉在线观看免费一区| 97久久超碰精品视觉盛宴| 一道本在线伊人蕉无码| 朝鲜美女黑毛bbw| 84pao国产成视频永久免费 | 娇妻玩4p被三个男人伺候电影 | 草裙社区精品视频三区免费看| 奶头好大狂揉60分钟视频|