在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Pig Insulin-like growth factor 1 receptor (IGF1R), partial

Recombinant Pig Insulin-like growth factor 1 receptor (IGF1R), partial

  • 中文名稱：
    野豬IGF1R重組蛋白
  • 貨號：
    CSB-YP011087PI
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    野豬IGF1R重組蛋白
  • 貨號：
    CSB-EP011087PI
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    野豬IGF1R重組蛋白
  • 貨號：
    CSB-EP011087PI-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    野豬IGF1R重組蛋白
  • 貨號：
    CSB-BP011087PI
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    野豬IGF1R重組蛋白
  • 貨號：
    CSB-MP011087PI
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    IGF1RInsulin-like growth factor 1 receptor; EC 2.7.10.1; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221; Fragments
  • 種屬：
    Sus scrofa (Pig)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R. When present in a hybrid receptor with INSR, binds IGF1.
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
  • 數據庫鏈接：


主站蜘蛛池模板： 国产做爰xxxⅹ久久久小说| 无人区一码卡二卡三乱码| 国产成人精品精品日本亚洲| 亚洲无线码免费| 亚洲精品乱码久久久久久中文字幕| 公么大龟弄得我好舒服秀婷视频| 日韩欧美人妻一区二区三区| 亚欧美日韩香蕉在线播放视频| 青青草国产精品免费观看| 亚洲中文字幕第一页在线| 中文无码日韩欧免费视频| 午夜男女很黄的视频| 国产又色又爽又黄的| 国产精品成人嫩草影院| 夜夜添无码试看一区二区三区| 欧美亚洲高清国产| 国产精品亚洲综合色区韩国| 无码一区二区波多野结衣播放搜索| 久久综合伊人九色综合| 性欧美videofree高清精品| 人妻av无码一区二区三区| 免费体验区试看120秒| 不卡无码av一区二区三区| 欧美性xxxx极品hd欧美风情| 亚洲va综合va国产产va中| 极品白嫩的小少妇| 又黄又爽又色的视频| 国产精品国产午夜免费看福利| 边喂奶边中出的人妻| 国产成人拍精品视频午夜网站| 无码人妻aⅴ一区二区三区有奶水| 国产aⅴ爽av久久久久久| 久久婷婷五月综合色奶水99啪| 丰满熟女人妻一区二区三 | 久久久久久久久久久国产| 精品久久久久久无码人妻蜜桃| 国产69精品久久久久乱码| 亚洲精品gv天堂无码男同| 成年无码av片| 无码专区 人妻系列 在线| 黑人又粗又大又硬a片|