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  4. Recombinant Pig Cystic fibrosis transmembrane conductance regulator (CFTR), partial

Recombinant Pig Cystic fibrosis transmembrane conductance regulator (CFTR), partial

  • 中文名稱：
    Recombinant Pig Cystic fibrosis transmembrane conductance regulator(CFTR) ,partial
  • 貨號：
    CSB-YP754284PI
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Pig Cystic fibrosis transmembrane conductance regulator(CFTR) ,partial
  • 貨號：
    CSB-EP754284PI
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Pig Cystic fibrosis transmembrane conductance regulator(CFTR) ,partial
  • 貨號：
    CSB-EP754284PI-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Pig Cystic fibrosis transmembrane conductance regulator(CFTR) ,partial
  • 貨號：
    CSB-BP754284PI
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Pig Cystic fibrosis transmembrane conductance regulator(CFTR) ,partial
  • 貨號：
    CSB-MP754284PI
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    CFTR; ABCC7; Cystic fibrosis transmembrane conductance regulator; CFTR; ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase; EC 5.6.1.6; cAMP-dependent chloride channel
  • 種屬：
    Sus scrofa (Pig)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
  • 基因功能參考文獻：
    1. Results suggest that acetylcholine does not regulate the activity of the CFTR in tracheal epithelia of pigs which opposes observation from studies using mice airway epithelium. PMID: 26286842
    2. Expression of CFTR-F508del interferes with smooth muscle cell calcium handling and decreases aortic responsiveness. PMID: 24183914
    3. Pseudomonas aeruginosa and other bacteria into the lumen of intact isolated swine tracheas triggers CFTR-dependent airway surface liquid secretion by the submucosal glands. PMID: 25136096
    4. TGF-beta1, via TGF-beta1 receptor I and p38 MAPK signaling, reduces CFTR expression to impair CFTR-mediated anion secretion, which would likely compound the effects associated with mild CFTR mutations and ultimately would compromise male fertility. PMID: 23903699
    5. The esophageal submucosal glands (SMG) secrete HCO(3)(-) and mucus into the esophageal lumen, where they contribute to acid clearance and epithelial protection. We investigated the presence of CFTR, its involvement in the secretion process, and the effect of cAMP on HCO3 secretion in this tissue. This is the first report on the presence of CFTR channels in the esophagus. PMID: 21474426
    6. data suggest that loss of CFTR directly alters Schwann cell function and that some nervous system defects in people with cystic fibrosis are likely primary PMID: 23382208
    7. The data suggest, that during bacterial infections and resulting release of proinflammatory cytokines, the glands are stimulated to secrete fluid, and this response is mediated by cAMP-activated CFTR. PMID: 22683572
    8. CFTR is required for maximal liquid absorption by lung alveoli under cAMP stimulation PMID: 22637155
    9. These findings reveal differences between nasal and tracheal glands, show defective fluid secretion in nasal glands of cystic fibrosis pigs, reveal some spared function in the DeltaF508 vs. null piglets. PMID: 21935358
    10. causal link between CFTR mutations and partial or total vas deferens and/or epididymis atresia at birth PMID: 21593481
    11. These data provide a molecular basis for interpreting enamel disease associated with disruptions to CFTR and AE2 expression. PMID: 21525720
    12. These results suggest that limited DeltaF508-mutant CFTR activity in is insufficient to prevent lung or gastrointestinal disease in CF pigs. PMID: 21411740
    13. CFTR mediates cAMP-stimulated Cl- secretion in a well-differentiated thyroid culture model. Knockout of CFTR promotes increased Na+ absorption by a mechanism other than increased epithelial sodium channel expression. PMID: 20729267
    14. These results indicate that CFTR provides the predominant transcellular pathway for Cl and HCO in porcine airway epithelia, and reduced anion permeability may initiate CF airway disease. PMID: 21145458
    15. Data show that PDE3A inhibition augments CFTR-dependent submucosal gland secretion and actin skeleton disruption decreases secretion. PMID: 20089840
    16. Expression of pCFTR was found to largely resemble that of hCFTR except for the kidney, brain, and cutaneous glands, which lack expression in pigs. PMID: 20498480
    17. The role of CFTR in submucosal gland fluid secretion was tested in pig airways. The reduced rate of gland fluid secretion after CFTR inhibition shown here provides strong evidence for the involvement of CFTR in glandular epithelial fluid transport. PMID: 15001557
    18. significant differences in CFTR channel mRNA and protein levels were present in atrial and ventricular cells, but not in regional ventricular cells across the ventricular wall from subepicardium to subendocardium PMID: 17112538
    19. analysis of species-dependent differences of CFTR-DeltaF508 in human, pig and mouse PMID: 17873061
    20. The mild cellular processing defect of pig DeltaF508-CFTR suggests that its gene-targeted pig model may not develop the lung and pancreatic phenotypes seen in CF patients. PMID: 18555011

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  • 亞細胞定位：
    Apical cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus.
  • 蛋白家族：
    ABC transporter superfamily, ABCC family, CFTR transporter (TC 3.A.1.202) subfamily
  • 數據庫鏈接：


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