在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Pig Calcium-activated potassium channel subunit alpha-1 (KCNMA1), partial

  • 中文名稱:
    野豬KCNMA1重組蛋白
  • 貨號:
    CSB-YP012077PI
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    野豬KCNMA1重組蛋白
  • 貨號:
    CSB-EP012077PI
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    野豬KCNMA1重組蛋白
  • 貨號:
    CSB-EP012077PI-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    野豬KCNMA1重組蛋白
  • 貨號:
    CSB-BP012077PI
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    野豬KCNMA1重組蛋白
  • 貨號:
    CSB-MP012077PI
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    KCNMA1; KCNMA; Calcium-activated potassium channel subunit alpha-1; BK channel; BKCA alpha; Calcium-activated potassium channel; subfamily M subunit alpha-1; K(VCA)alpha; KCa1.1; Maxi K channel; MaxiK; Slo-alpha; Slo1; Slowpoke homolog; Slo homolog; Fragment
  • 種屬:
    Sus scrofa (Pig)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).
  • 基因功能參考文獻:
    1. Porcine K2P3.1 channels exhibit atrial expression and functional properties similar to their human orthologs, supporting a general role as antiarrhythmic drug targets. PMID: 24952150
    2. Inositol trisphosphate is an activator of BKCA channels in porcine coronary smooth muscle cells and exerts a coronary artery-relaxing effect. PMID: 24012825
    3. Findings suggest that a component of the bradykinin signaling pathway, which stimulates BK(Ca) channels, is enhanced by exercise training in collateral-dependent arterioles and suggest a potential role for H2O2 as the mediator. PMID: 23002811
    4. Testerone-induced relaxation of endothelium-denuded coronary arteries is mediated, at least in part, by enhanced NO production, leading to cGMP synthesis and PKG activation, which, in turn, opens BK(Ca) channels. PMID: 22081702
    5. Inhibition of BK(Ca) channels had no effect on reactive hyperemia in either lean or metabolic syndrome swine. PMID: 20118408
    6. Diminished function of BK(Ca) channels does not contribute to the impairment of myocardial oxygen-supply demand balance in metabolic syndrome. PMID: 20044440

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Potassium channel family, Calcium-activated (TC 1.A.1.3) subfamily, KCa1.1/KCNMA1 sub-subfamily
  • 數據庫鏈接:


主站蜘蛛池模板: 亚洲人成人无码网www国产| 亚洲码欧美码一区二区三区| 欧美激情一区二区三区在线| 亚洲a∨国产av综合av| 国产精品青青青在线观看| 丰满少妇高潮惨叫久久久| 国产精品va无码一区二区| 柠檬福利精品视频导航| 在线观看国产日韩亚洲中| 国产无遮挡又黄又爽网站| 日日碰狠狠添天天爽| 亚洲精品熟女国产| 久久亚洲人成电影网| 精品无码久久久久久久动漫| 天天干天天射天天操| 香蕉在线精品视频在线| 亚洲精品一区二区国产精华液 | 女人被男人躁得好爽免费视频| 日本人妻丰满熟妇久久久久久 | 无码h黄动漫在线播放网站| av国産精品毛片一区二区视频| 欧洲美熟女乱又伦| 午夜福利国产成人无码gif动图 | 一本一道精品欧美中文字幕| 美女粉嫩饱满的一线天mp4| 国产精品女视频一区二区| 无码av高潮抽搐流白浆| 国产在线不卡视频免费视频| 久精品视频在线观看免费| 理论片午午伦夜理片影院99| 中文字幕在线观看| 国色天香精品一卡2卡3卡4| 久久久久99精品成人片| √天堂资源地址中文在线| 一卡二卡3卡4卡视频免费播放| 亚洲欲色欲香天天综合网| 亚洲va国产va天堂va久久| 伊在人天堂亚洲香蕉精品区| 国产午夜草莓视频在线观看| 成 人 免费观看网站| 欧美综合自拍亚洲综合图片区|