在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Pig Amyloid beta A4 protein (APP), partial

  • 中文名稱:
    Recombinant Pig Amyloid beta A4 protein(APP) ,partial
  • 貨號(hào):
    CSB-YP001950PI1
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Pig Amyloid beta A4 protein(APP) ,partial
  • 貨號(hào):
    CSB-EP001950PI1
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Pig Amyloid beta A4 protein(APP) ,partial
  • 貨號(hào):
    CSB-EP001950PI1-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Pig Amyloid beta A4 protein(APP) ,partial
  • 貨號(hào):
    CSB-BP001950PI1
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Pig Amyloid beta A4 protein(APP) ,partial
  • 貨號(hào):
    CSB-MP001950PI1
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    APP; A4; AD1; Amyloid-beta precursor protein; ABPP; APP; Alzheimer disease amyloid A4 protein homolog; Alzheimer disease amyloid protein; Amyloid precursor protein; Amyloid-beta; A4 precursor protein; Amyloid-beta A4 protein
  • 種屬:
    Sus scrofa (Pig)
  • 蛋白長度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapes in axons. May be involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.; Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Binds transient metals such as copper, zinc and iron.; The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.; N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
  • 基因功能參考文獻(xiàn):
    1. APPsw mutation for Alzheimer's disease is not associated with object recognition. PMID: 22661126
    2. Amyloid-beta inhibits No-cGMP signaling in a CD36- and CD47-dependent manner PMID: 21203512
    3. These experiments demonstrate the roles of Chol and ApoE in the modulation of membrane insertion of APP. PMID: 15202933
    4. Two novel transcript variants of porcine APP have been identified, producing isoforms of 695 and 751 amino acids, respectively. PMID: 16934345
    5. APP could be acting through a semaphorin receptor as well PMID: 17335780

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Perikaryon. Cell projection, growth cone. Membrane, clathrin-coated pit. Early endosome. Cytoplasmic vesicle.; [C83]: Endoplasmic reticulum. Golgi apparatus. Early endosome.; [C99]: Early endosome.; [Soluble APP-beta]: Secreted.; [Amyloid-beta protein 42]: Cell surface.; [Gamma-secretase C-terminal fragment 59]: Nucleus. Cytoplasm.
  • 蛋白家族:
    APP family
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 国产suv精品一区二区| 四虎成人国产精品永久在线| 国产 国语对白 露脸| av无码精品一区二区三区| 无码专区天天躁天天躁在线| 中文无码一区二区视频在线播放量| 他掀开裙子把舌头伸进去添视频| 国内自拍视频一区二区三区| 久久久亚洲精华液精华液精华液| 一本一本久久a久久综合精品蜜桃| 亚洲男人的天堂一区二区| 亚洲加勒比无码一区二区| 人妻无码中文专区久久app| 国产精品无码一区二区在线a片| 影视av久久久噜噜噜噜噜三级 | 亚洲国产精品久久久久秋霞小说| 印度女人狂野牲交| 人妻夜夜爽天天爽三区丁香花| 深夜国产一区二区三区在线看| 欧美老妇与禽交| 亚洲精品图片区小说区| 久久亚洲国产成人精品无码区 | 欧美肥老太交性506070| 日产精品一区二区| 日产国产精品亚洲系列| 亚洲人成电影免费观看在线看| 国产做爰xxxⅹ久久久精华液| 少妇真实被内射视频三四区| 色欲久久人妻内射| 亚州日本乱码一区二区三区| 亚洲精品少妇30p| 国产精品亚洲一区二区三区| 亚洲国产av无码一区二区三区| 国产高清不卡一区二区| 18精品久久久无码午夜福利| 成人免费无遮挡在线播放| 成人做爰www网站视频下载| 国产美女精品一区二区三区 | 亚洲另类欧美综合在线| 日本丰满护士videossexhd| 人与嘼交av免费|