在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Pig Aminopeptidase N (ANPEP), partial

In Stock
  • 中文名稱:
    Recombinant Pig Aminopeptidase N(ANPEP),partial
  • 貨號:
    CSB-EP001827PIa0
  • 規格:
    ¥2328
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    AP-N;pAPN;Alanyl aminopeptidase;Aminopeptidase M;AP-M;Microsomal aminopeptidase;gp130;CD antigen CD13
  • 種屬:
    Sus scrofa (Pig)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    44.2 kDa
  • 表達區域:
    616-963aa
  • 氨基酸序列
    WVLLNVNVTGYFQVNYDEDNWRMIQHQLQTNLSVIPVINRAQVIYDSFNLATAHMVPVTLALDNTLFLNGEKEYMPWQAALSSLSYFSLMFDRSEVYGPMKKYLRKQVEPLFQHFETLTKNWTERPENLMDQYSEINAISTACSNGLPQCENLAKTLFDQWMSDPENNPIHPNLRSTIYCNAIAQGGQDQWDFAWGQLQQAQLVNEADKLRSALACSNEVWLLNRYLGYTLNPDLIRKQDATSTINSIASNVIGQPLAWDFVQSNWKKLFQDYGGGSFSFSNLIQGVTRRFSSEFELQQLEQFKKNNMDVGFGSGTRALEQALEKTKANIKWVKENKEVVLNWFIEHS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. It is able to degrade Leu-enkephalin and Met-enkephalin but not cholecystokinin CCK8, neuromedin C (GRP-10), somatostatin-14, substance P and vasoactive intestinal peptide. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity.; (Microbial infection) In case of porcine transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCoV) infections, serves as a receptor for TGEV and PRCoV spike glycoprotein in a species-specific manner.
  • 基因功能參考文獻:
    1. Genetic ablation of APN expression had no effect on infectability by porcine epidemic diarrhea virus, demonstrating that APN is not essential for porcine epidemic diarrhea virus cell entry. PMID: 28363778
    2. pAPN is not a functional receptor for porcine epidemic diarrhea virus, but promotes the infection of PEDV through its protease activity. PMID: 27449937
    3. The C-terminal domain of the S1 domain of porcine epidemic diarrhea virus is bound to swine pAPN. PMID: 26907329
    4. Data indicate that fluorogenic substrates can be successfully used to identify aminopeptidase N and to measure their activity in cell lysates. PMID: 26449746
    5. SPC subdomain of APN plays a key role in cell entry of PEDV and its expression permits PEDV growth PMID: 26044794
    6. Porcine epidemic diarrhea virus recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptor N-acetylneuraminic acid. PMID: 25787280
    7. These data demonstrate that pAPN, the cellular receptor for porcine epidemic diarrhea virus, mediates polarized virus infection. PMID: 25681796
    8. It was concluded that the difference in F4 binding to ANPEP is due to modifications in its carbohydrate moieties. PMID: 24663207
    9. The region aa 673-722 of the C subunit of porcine aminopeptidase N is indicated to play a key role in swine transmissible gastroenteritis virus binding. PMID: 22083718
    10. The binding ability of four truncated porcine aminopeptidase N proteins to transmissible gastroenteritis virus (TGEV), a porcine coronavirus, was analyzed by ELISA and immunoblotting. PMID: 20643168
    11. Aminoeptidase N is the major for cell entry system of porcine epidemic diarrhea virus infection. PMID: 20074871
    12. results demonstrate that aminopeptidase N reduces basolateral Na(+)-K(+)-ATPase levels via ANG IV/AGTRIV signaling. This novel pathway may be important in renal adaptation to high salt PMID: 17634404

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type II membrane protein.
  • 蛋白家族:
    Peptidase M1 family
  • 數據庫鏈接:


主站蜘蛛池模板: 又黄又爽又色的免费网站| 色与欲影视天天看综合网| 国产精品女上位好爽在线| 国产女人高潮叫床免费视频| 国产乱子伦一区二区三区=| 无码中文字幕日韩专区视频| 国产99久一区二区三区a片| 亚洲精品久久7777777国产| 成人亚洲a片v一区二区三区动漫| 两个黑人大战嫩白金发美女| 亚洲欧美国产毛片在线| 国内熟妇人妻色在线视频| 人妻系列无码专区免费视频| 精品国产第一国产综合精品| 人人妻人人妻人人片av| 五月综合色婷婷在线观看| 色偷偷女人的天堂亚洲网| 亚洲色欲色欱www在线| 东北少妇不戴套对白第一次 | 精品国产天堂综合一区在线| 狠狠躁夜夜躁av网站中文字幕| 人妻丰满熟妇无码区免费| 中文字幕一区二区精品区| 久久九九有精品国产尤物| 久久久精品波多野结衣| 久艹视频免费看| 日本少妇xxxx做受| 无码人妻少妇色欲av一区二区| 99e久热只有精品8在线直播| 久久无码无码久久综合综合| 亚洲中文在线精品国产| 少妇性bbb搡bbb爽爽爽欧美| 日日摸天天碰中文字幕你懂的| 熟女chachacha性少妇| 免费人成在线观看网站| 国自产偷精品不卡在线| 精品无码国产自产拍在线观看蜜| 蜜臀色欲av在线播放国产日韩| 五月天激情婷婷婷久久| 亚洲人精品午夜射精日韩 | 亚洲日韩穿丝袜在线推荐|