在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Pig 5'-AMP-activated protein kinase subunit gamma-3 (PRKAG3), partial

Recombinant Pig 5'-AMP-activated protein kinase subunit gamma-3 (PRKAG3), partial

  • 中文名稱：
    野豬PRKAG3重組蛋白
  • 貨號(hào)：
    CSB-YP873545PI
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    野豬PRKAG3重組蛋白
  • 貨號(hào)：
    CSB-EP873545PI
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    野豬PRKAG3重組蛋白
  • 貨號(hào)：
    CSB-EP873545PI-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    野豬PRKAG3重組蛋白
  • 貨號(hào)：
    CSB-BP873545PI
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    野豬PRKAG3重組蛋白
  • 貨號(hào)：
    CSB-MP873545PI
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    PRKAG35'-AMP-activated protein kinase subunit gamma-3; AMPK gamma3; AMPK subunit gamma-3
  • 種屬：
    Sus scrofa (Pig)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. AMPK also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. The AMPK gamma3 subunit is a non-catalytic subunit with a regulatory role in muscle energy metabolism. It mediates binding to AMP, ADP and ATP, leading to AMPK activation or inhibition: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
  • 基因功能參考文獻(xiàn)：
    1. Activity of glycogen synthase without the allosteric activator glucose 6-phosphate was decreased in gain of function AMPKgamma3(R200Q) relative to all other genotypes PMID: 27302990
    2. Greater net lactate accumulation postmortem (i.e., glycolytic flux) coupled with a lower buffering capacity explains the lower ultimate pH of meat from AMPKgamma3(R200Q) mutant pigs. PMID: 26241465
    3. allelic frequencies of PRKAG3 in several pig breeds PMID: 24074175
    4. The variation in the promoter region of the porcine PRKAG3 gene has associations with meat quality phenotypes, including traits which are influenced by glycolytic potential and muscle metabolism in a breed-dependent manner. PMID: 22831392
    5. PRKAG3 mutation influences muscle characteristics and promotes an oxidative phenotype to a varying degree among muscles with different functions PMID: 21435205
    6. increased rate of glycogen synthesis following exercise in pigs carrying the PRKAG3 mutation correlates with an increased signalling response of Akt and its substrate, AS160. PMID: 20028849
    7. Genetic variation of PRKAG3 was studied in indigenous breeds of China. PMID: 15231235
    8. the R225Q mutation of PRKAG3 is associated with higher basal AMPK activity and diminished AMP dependence PMID: 15247217
    9. findings suggest that the R200Q mutation results in a constitutively active enzyme, leading to hyperaccumulation of glycogen due to the increased influx of glucose PMID: 15274139

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Defects in PRKAG3 are the cause of the RN- phenotype which is associated with excess glycogen content (about 70%) in skeletal muscle. This mutation originated in the hampshire breed pigs and has beneficial effects on meat content but detrimental effects on processing yield.
  • 蛋白家族：
    5'-AMP-activated protein kinase gamma subunit family
  • 組織特異性：
    Muscle.
  • 數(shù)據(jù)庫(kù)鏈接：


主站蜘蛛池模板： 国产精品99久久久久久董美香| 22222se男人的天堂| 亚洲爆乳无码专区| 亚洲伊人色欲综合网| 色综合av男人的天堂伊人| 免费无码av片在线观看| 欧美黑人xxxx又粗又长| 中文有码人妻字幕在线| 国内精品伊人久久久久网站| 777午夜福利理论电影网| 亚洲第一区无码专区| 三级在线看中文字幕完整版| 色欲视频综合免费天天| 国产自在自线午夜精品| 又大又硬又黄的免费视频| 天天做天天爱夜夜夜爽毛片| 亚洲欧美日韩国产成人| 少妇人妻上班偷人精品视频| 久久婷婷五月综合色俺也想去| 亚洲精品久久久www小说| 成人永久免费网站在线观看| 天天干天天日| 免费国产成人午夜福利电影| 日韩不卡1卡2卡三卡网站| 久久精品国产成人av| 解开人妻的裙子猛烈进入| 永久免费观看的毛片手机视频| 午夜人妻理论片天堂影院| 国产真实伦在线观看| 老熟妇仑乱一区二区视頻| 国产日韩精品欧美一区喷水| 国产在线码观看超清无码视频| 国产成人精品手机在线观看 | 亚洲男人的天堂在线播放| 中文字幕v亚洲ⅴv天堂| 2020精品国产视| 精品国产午夜理论片不卡精品| 色悠久久久久综合网国产| 精品免费久久久久久久| 粉嫩被粗大进进出出视频| 男女性爽大片视频免费看|