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  4. Recombinant Phosphatidylinositol 3-kinase age-1 (age-1), partial

Recombinant Phosphatidylinositol 3-kinase age-1 (age-1), partial

  • 中文名稱：
    Recombinant Phosphatidylinositol 3-kinase age-1(age-1) ,partial
  • 貨號：
    CSB-YP842432CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Phosphatidylinositol 3-kinase age-1(age-1) ,partial
  • 貨號：
    CSB-EP842432CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Phosphatidylinositol 3-kinase age-1(age-1) ,partial
  • 貨號：
    CSB-EP842432CXY-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Phosphatidylinositol 3-kinase age-1(age-1) ,partial
  • 貨號：
    CSB-BP842432CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Phosphatidylinositol 3-kinase age-1(age-1) ,partial
  • 貨號：
    CSB-MP842432CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    age-1
  • Uniprot No.：
  • 別名：
    age-1; B0334.8Phosphatidylinositol 3-kinase age-1; PI3-kinase age-1; PI3K age-1; PtdIns-3-kinase age-1; EC 2.7.1.137; Aging alteration protein 1
  • 種屬：
    Caenorhabditis elegans
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3. Could function in the development or neuroendocrine signaling of the dauer pathway. Mediates susceptibility to enteropathogenic E.coli infection. May negatively regulate AYI interneuron neurite outgrowth. Plays a role in aversive olfactory learning when an odor is associated with food deprivation. Regulates this process by promoting the nuclear relocalization of egl-4 in AWC olfactory neurons after odor conditioning.
  • 基因功能參考文獻：
    1. synaptic PI3K Age-1 is crucial for the behavioral switch caused by learning. PMID: 25035490
    2. ASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target PMID: 23049887
    3. The number of nonredundant gene ontology categories significantly distinguishing age-1 alleles of exceptional longevity increased from sevenfold to greater than ninefold. PMID: 22021389
    4. conclude that extreme age-1 deficiency invokes multiple transcriptional changes. PMID: 19764929
    5. During neuronal development, mig-10 and the C. elegans Ena/VASP homolog unc-34 cooperate to guide axons toward UNC-6 (netrin) and away from SLT-1 (Slit). PMID: 16618541
    6. Results showed that age-1 mutant phenotypes identified activating mutations in two known pathway components, providing insights into their regulation. PMID: 17020605
    7. C. elegans strains bearing homozygous nonsense mutations in the age-1 gene after prolonged developmental times at 15-20 degrees C, mature into extremely long-lived adults with near-normal feeding rates and motility. PMID: 17996009
    8. In the age-1 allele, which activates an insulin/insulin-like growth factor-1 (Ins/IGF-1) signaling pathway, the superoxide dismutase (SOD) and catalase activities increased during normal aging. PMID: 18285659
    9. Reuslts identify four genes to be required for the quercetin derived lifespan extension in C. elegans, namely age-1, daf-2, unc-43 and sek-1. PMID: 19043800
    10. Our findings demonstrate a drug-specific interaction between clozapine and the PI3K/insulin-signaling pathway in C. elegans. PMID: 19322168
    11. Suppression of age-1 contributes to exceptional survival. PMID: 19360094
    12. Studies show that strong mutations to the encoding AGE-1/PI3KCS achieve unprecedented longevity by orchestrating the modulation (predominantly silencing) of multiple signaling pathways. PMID: 19465083

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  • 蛋白家族：
    PI3/PI4-kinase family
  • 數據庫鏈接：

    KEGG: cel:CELE_B0334.8

    STRING: 6239.B0334.8

    UniGene: Cel.18292



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