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  4. Recombinant Neosartorya fumigata Serine/threonine-protein phosphatase 2B catalytic subunit (cnaA), partial

Recombinant Neosartorya fumigata Serine/threonine-protein phosphatase 2B catalytic subunit (cnaA), partial

  • 中文名稱：
    Recombinant Neosartorya fumigata Serine/threonine-protein phosphatase 2B catalytic subunit(cnaA) ,partial
  • 貨號：
    CSB-YP709364NGS
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Neosartorya fumigata Serine/threonine-protein phosphatase 2B catalytic subunit(cnaA) ,partial
  • 貨號：
    CSB-EP709364NGS
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Neosartorya fumigata Serine/threonine-protein phosphatase 2B catalytic subunit(cnaA) ,partial
  • 貨號：
    CSB-EP709364NGS-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Neosartorya fumigata Serine/threonine-protein phosphatase 2B catalytic subunit(cnaA) ,partial
  • 貨號：
    CSB-BP709364NGS
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Neosartorya fumigata Serine/threonine-protein phosphatase 2B catalytic subunit(cnaA) ,partial
  • 貨號：
    CSB-MP709364NGS
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    cnaA
  • Uniprot No.：
  • 別名：
    cnaA; AFUA_5G09360; Serine/threonine-protein phosphatase 2B catalytic subunit; EC 3.1.3.16; Calmodulin-dependent calcineurin A subunit
  • 種屬：
    Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
  • 基因功能參考文獻：
    1. Modeling A. fumigatus CnaA confirmed that the FMDVF motif forms a bridge between the two known substrate-binding motifs, PxIxIT and LxVP, and concurrent mutations (F368A D370A; F368A F372A) in the FMDVF motif disrupt CnaA-substrate interaction at the septum. PMID: 26864964
    2. circular dichroism studies revealed that, despite proximity to the CaM-binding domain of CnaA, phosphorylation of the SPRR does not alter protein folding following CaM binding. PMID: 23990785
    3. Identified 37 CalA-interacting proteins that interact with the catalytic subunit of calcineurin (CalA) in Aspergillus fumigatus, including the nucleoside diphosphate kinase (SwoH). PMID: 22634424
    4. Galactomannan release from the cell wall is calcineurin-dependent. PMID: 21107627
    5. Calcineurin appears to play a globally conserved role in the virulence of several pathogenic fungi and yet plays specialized roles in each and can be an excellent target for therapeutic intervention. PMID: 16835453
    6. CrzA is an important downstream effector of calcineurin that controls morphology in A. fumigatus. PMID: 18456861
    7. CnaA-EGFP localized in actively growing hyphal tips and at junctions between the vesicle and phialides in an actin-dependent manner. PMID: 18606829

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  • 蛋白家族：
    PPP phosphatase family, PP-2B subfamily
  • 數據庫鏈接：


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