在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Neosartorya fumigata Nonribosomal peptide synthetase 10 (NRPS10), partial

  • 中文名稱:
    新薩托菌屬gliP重組蛋白
  • 貨號:
    CSB-YP681240NGS
  • 說明書:
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    新薩托菌屬gliP重組蛋白
  • 貨號:
    CSB-EP681240NGS
  • 說明書:
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    新薩托菌屬gliP重組蛋白
  • 貨號:
    CSB-EP681240NGS-B
  • 說明書:
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    新薩托菌屬gliP重組蛋白
  • 貨號:
    CSB-BP681240NGS
  • 說明書:
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    新薩托菌屬gliP重組蛋白
  • 貨號:
    CSB-MP681240NGS
  • 說明書:
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    gliP
  • Uniprot No.:
  • 別名:
    gliP; NRPS10; pesK; AFUA_6G09660; Nonribosomal peptide synthetase gliP; NRPS gliP; EC 6.3.2.-; Gliotoxin biosynthesis protein P
  • 種屬:
    Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of gliotoxin, a member of the epipolythiodioxopiperazine (ETP) class of toxins characterized by a disulfide-bridged cyclic dipeptide. The first step in gliotoxin biosynthesis is the condensation of serine and phenylalanine to form the cyclo-L-phenylalanyl-L-serine diketopiperazine (DKP) by the NRPS gliP. GliP is also able to produce the DKP cyclo-L-tryptophanyl-L-serine, suggesting that the substrate specificity of the first adenylation (A) domain in gliP is sufficiently relaxed to accommodate both L-Phe and L-Trp. The cytochrome P450 monooxygenase gliC has been shown to catalyze the subsequent hydroxylation of the alpha-carbon of L-Phe in cyclo-L-phenylalanyl-L-serine whereas the second cytochrome P450 enzyme, gliF, is presumably involved in the modification of the DKP side chain. The glutathione S-transferase (GST) gliG then forms a bis-glutathionylated biosynthetic intermediate which is responsible for the sulfurization of gliotoxin. This bis-glutathionylated intermediate is subsequently processed by the gamma-glutamyl cyclotransferase gliK to remove both gamma-glutamyl moieties. Subsequent processing via gliI yields a biosynthetic intermediate, which is N-methylated via the N-methyltransferase gliN, before the gliotoxin oxidoreductase gliT-mediated disulfide bridge closure. GliN-mediated amide methylation confers stability to ETP, damping the spontaneous formation of tri- and tetrasulfides. Intracellular dithiol gliotoxin oxidized by gliT is subsequently effluxed by gliA. Gliotoxin contributes to pathogenesis during invasive aspergillosis. In macrophages and neutrophils, gliotoxin showed inhibition of various different cell functions including cytokine production, antigen presentation, phagocytosis, and production of reactive oxygen species.
  • 基因功能參考文獻:
    1. Culture supernatants of A. fumigatus strains lacking gliotoxin production showed a significantly lower cytotoxicity on macrophage-like cells and T-cells in vitro, although the gliP gene was present in 2 strains. PMID: 17574915
    2. The gliP gene encodes a nonribosomal peptide synthase that catalyzes the first step in gliotoxin biosynthesis. PMID: 17601876
    3. Transcription of gliP, involved in the synthesis of gliotoxin, was drastically reduced in B-5233laeADelta. PMID: 17630330
  • 蛋白家族:
    NRP synthase family
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 国产精品禁18久久久夂久| 久久香蕉综合色一综合色88| 最近中文字幕免费大全在线| 伊人中文字幕无码专区| 亚洲码欧美码一区二区三区| 色窝窝无码一区二区三区| 免费无码av片在线观看潮喷 | 国产xxxx视频在线观看| 一个人在线观看免费中文www | √天堂资源地址中文在线| 久久亚洲人成综合网| 高潮好爽视频在线观看| 国产边打电话边被躁视频| 精品久久久久久亚洲综合网| 国产白丝精品爽爽久久蜜臀| 巨大乳做爰视频在线看| 在线观看片免费人成视频无码| 野花社区视频www官网| 护士脱了内裤让我爽了一夜视频| 日韩亚洲中字无码一区二区三区 | 国产情侣久久久久aⅴ免费| 失禁潮痉挛潮喷av在线无码| 国产高清av喷水白丝护士| 国产成年无码v片在线| 欧美艳星nikki激情办公室| 国产做a爰片久久毛片a片白丝| 国产精品福利一区二区久久| 成人爽a毛片免费啪啪| _97夜夜澡人人爽人人喊_欧美| 亚洲欧美偷拍另类a∨| 国产免码va在线观看免费| 伊人久久久精品区aaa片| 日韩精品一区二区三区在线观看l| 国产欧美丝袜在线二区| 国产精品99久久久久久人| 精品亚洲国产成av人片传媒| 中文字幕av伊人av无码av狼人 | 国产精品人成视频免费国产| 天堂www中文在线资源| 深夜国产一区二区三区在线看| 正在播放酒店约少妇高潮|