在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Zinc finger protein Helios (Ikzf2)

Recombinant Mouse Zinc finger protein Helios (Ikzf2)

  • 中文名稱：
    小鼠Ikzf2重組蛋白
  • 貨號：
    CSB-YP011576MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Ikzf2重組蛋白
  • 貨號：
    CSB-EP011576MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Ikzf2重組蛋白
  • 貨號：
    CSB-BP011576MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Ikzf2重組蛋白
  • 貨號：
    CSB-MP011576MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Ikzf2
  • Uniprot No.：
  • 別名：
    Ikzf2; Helios; Zfpn1a2; Znfn1a2; Zinc finger protein Helios; Ikaros family zinc finger protein 2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-526
  • 氨基酸序列
    METDAIDGYI TCDNELSPEG EHANMAIDLT SSTPNGQHAS PSHMTSTNSV KLEMQSDEEC DRQPLSREDE IRGHDEGSSL EEPLIESSEV ADNRKVQDLQ GEGGIRLPNG KLKCDVCGMV CIGPNVLMVH KRSHTGERPF HCNQCGASFT QKGNLLRHIK LHSGEKPFKC PFCSYACRRR DALTGHLRTH SVGKPHKCNY CGRSYKQRSS LEEHKERCHN YLQNVSMEAA GQVMSHHVPP MEDCKEQEPI MDNNISLVPF ERPAVIEKLT ANMGKRKSST PQKFVGEKLM RFSYPDIHFD MNLTYEKEAE LMQSHMMDQA INNAITYLGA EALHPLMQHA PSTIAEVAPV ISSAYSQVYH PNRIERPISR ETSDSHENNM DGPISLIRPK SRPQEREASP SNSCLDSTDS ESSHDDRQSY QGNPALNPKR KQSPAYMKED VKALDATKAP KGSLKDIYKV FNGEGEQIRA FKCEHCRVLF LDHVMYTIHM GCHGYRDPLE CNICGYRSQD RYEFSSHIVR GEHTFH
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Associates with Ikaros at centromeric heterochromatin.
  • 基因功能參考文獻：
    1. These data provide a genetic basis for the unstable phenotype of Helios-deficient Tregs within the inflammatory environment of tumors and suggest that immune milieu-dependent alterations in gene expression are a central feature of Treg conversion. PMID: 29440380
    2. He is involved in the correct development of a subset of striatopallidal medium spiny neurons. PMID: 28289129
    3. Helios controls certain aspects of Treg-suppressive function, differentiation, and survival. PMID: 26582951
    4. this study reports that impaired expression of the transcription factor Helios by FoxP3+ CD4 and Qa-1-restricted CD8 Tregs results in defective regulatory activity and autoimmunity in mice. PMID: 26472910
    5. data suggest that a subset of DN T cells, identified by the expression of PD-1 and Helios, represent self-reactive cells; results provide an explanation for the origin of DN T cells and introduce CD8 loss as a process associated with self-Ag encounter PMID: 25825451
    6. results demonstrate that Helios is expressed by thymic and peripheral T cells that are being driven to tolerance in response to a genuine autoantigen PMID: 24740292
    7. identify Helios as the first marker known to diverge during positive and negative selection of thymocytes PMID: 23337809
    8. Helios regulates IL-2 production in Tregs by suppressing Il2 gene transcription. Loss of Helios in Tregs breaks their anergic phenotype and results in derepression of the Il2 locus. PMID: 23275607
    9. Helios expression spatially coincides with the early pattern of expression of the mature markers of striatal projection neurons. PMID: 22142223
    10. In tumor-bearing mice, Helios(+) regulatory T cells were relatively over-represented in the tumor-mass. PMID: 22479644
    11. Data found that Helios-negative T cells are enriched for naive T cell phenotypes and vice versa. Moreover, Helios can be induced during T cell activation and proliferation, but regresses in the same cells under resting conditions. PMID: 21918685
    12. down-regulation of NK cell activity by NKp46 was associated with the silencing of the Helios transcription factor in NK cells PMID: 22267813
    13. show that Helios is upregulated in CD4(+)CD25(+) regulatory T cells. PMID: 20226531
    14. silencing of Helios is critical for normal B cell function PMID: 16148093
    15. results demonstrate a vital function for Helios in maintaining normal homeostasis of developing T cells and formally show that non-DNA-binding isoforms of Helios are lymphomagenic if aberrantly expressed within the T-cell lineage PMID: 17110463
    16. Helios is not essential for T cells; its function can be compensated for by other members of the Ikaros family. PMID: 19620299

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Ikaros C2H2-type zinc-finger protein family
  • 組織特異性：
    Restricted to the T-cell lineage. Abundant in thymus, low expression in bone marrow and brain and no detectable expression in spleen, liver, kidney or muscle.
  • 數據庫鏈接：


主站蜘蛛池模板： 欧美 在线 成 人怡红院| 欧美gv在线观看| 中文人妻av久久人妻水密桃| 国产av影片麻豆精品传媒| 福利姬国产精品一区在线| 久久久www成人免费无遮挡大片 | 羞羞影院午夜男女爽爽| 特级毛片在线大全免费播放| 国产成人精品a视频一区| 无码人妻aⅴ一区二区三区玉蒲团 日本三级香港三级人妇三 | 18无码粉嫩小泬无套在线观看| 久久精品无码专区免费| 日日噜噜噜夜夜爽爽狠狠视频| 成人看片黄a免费看在线| 国语自产精品视频在 视频| 国产成人毛片在线视频| 成人免费xxxxx在线观看| 国产黑色丝袜在线观看下| 8ⅹ8x擦拨擦拨成人免费视频| 色五月丁香五月综合五月| 精品无码人妻一区二区三区| 人妻无码一区二区不卡无码av| 人人爽人人爽人人片av东京热| 无码人妻一区二区三区免费n鬼逝| 国产精品久久久久久人妻精品动漫| 欧美性videos高清精品| 成人午夜电影福利免费| 2022一本久道久久综合狂躁| 亚洲另类春色校园小说| 婷婷六月丁香缴 清| 亚洲精品第一国产综合国服瑶 | 国产精品久久久久久亚洲影视| 久久久久四虎精品免费入口| 少妇被粗大猛进进出出| 国产精品久久久久av福利动漫| 国产清纯在线一区二区www| 中日韩产精品1卡二卡三卡| 色综合久久蜜芽国产精品| 东京热一精品无码av| 欧美日产国产精品日产| 丁香花在线影院观看在线播放|