在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse WD repeat-containing protein 5 (Wdr5)

Recombinant Mouse WD repeat-containing protein 5 (Wdr5)

  • 中文名稱：
    小鼠Wdr5重組蛋白
  • 貨號：
    CSB-YP026038MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Wdr5重組蛋白
  • 貨號：
    CSB-EP026038MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Wdr5重組蛋白
  • 貨號：
    CSB-EP026038MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Wdr5重組蛋白
  • 貨號：
    CSB-BP026038MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Wdr5重組蛋白
  • 貨號：
    CSB-MP026038MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Wdr5
  • Uniprot No.：
  • 別名：
    Wdr5; Big; Big3WD repeat-containing protein 5; BMP2-induced 3-kb gene protein; WD repeat-containing protein BIG-3
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-334
  • 氨基酸序列
    MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH TDVVISTACHPTENIIASAALENDKTIKLWKSDC
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation. In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B.
  • 基因功能參考文獻：
    1. Cbx8 associates with non-PRC1 complexes containing the H3K4 methyltransferase complex component WDR5, which together regulate Notch gene expression. PMID: 27346354
    2. Wdr5 suppression also reduced IFNgamma, Il-1beta, and TNFalpha induced chemokine gene expression in b-cells without affecting islet-cell survival or b-cell function after 48hrs, but did begin to increase islet-cell apoptosis PMID: 26505193
    3. results suggest that specific RNAs are integral inputs into the WDR5-MLL complex for maintenance of the active chromatin state and embryonic stem cell fates PMID: 24521543
    4. Data show that broad association of myc proto-oncogene protein MYC with chromatin depends on interaction with the WD40-repeat protein WDR5. PMID: 25818646
    5. BIG3 inhibits insulin granule biogenesis and insulin secretion. PMID: 24711543
    6. BIG3 negatively regulates insulin granule exocytosis by restricting insulin granule biogenesis without the release kinetics of individual granules at the final exocytotic steps being affected. PMID: 25139048
    7. Depletion of KAT2B or WDR5 decreased gluconeogenic gene expression. PMID: 24051374
    8. analysis of a novel mechanism for epigenetic control of SMC-marker gene expression during development through interaction of WDR5, homeodomain proteins, and chromatin remodeling enzymes PMID: 21531708
    9. Study shows that WD repeat domain 5 (Wdr5), a core member of the mammalian Trithorax (trxG) complex, positively correlates with the undifferentiated state and is a regulator of ES cell self-renewal. PMID: 21477851
    10. Characterization of a novel WDR5-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 lysine 4 by mixed lineage leukemia protein-1. PMID: 20716525
    11. WDR5 is essential in assembling a virus-induced VISA-associated complex and plays an important role in virus-triggered induction of type I interferons. PMID: 20080758
    12. BIG-3 accelerates chondrocyte differentiation in vitro, and is expressed in the growth plate during embryonic development, so is is likely to play an in vivo regulatory role in the developing growth plate. PMID: 14657013
    13. identified two proteins, NONO and WDR5, that can associate with the mammalian PER1 protein; WDR5 augmented PER-mediated transcriptional repression, and its reduction by RNAi diminished circadian histone methylations at the promoter of a clock gene PMID: 15860628
    14. Wdr5 accelerates osteoblast differentiation in association with activation of the canonical Wnt pathway. PMID: 16730692
    15. Wdr5 is present on the Wnt1 promoter and on canonical Wnt response elements of the c-myc and Runx-2 promoters. PMID: 18201971
    16. Perichondrium expression of Wdr5 regulates chondrocyte proliferation and differentiation. PMID: 19217897

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    WD repeat WDR5/wds family
  • 組織特異性：
    Expressed in liver (at protein level). Detected in brain, testis and kidney.
  • 數據庫鏈接：


主站蜘蛛池模板： 在线a亚洲v天堂网2018| 人妻少妇乱子伦精品| 无码国产片观看| 被拉到野外强要好爽黑人| 国产日韩在线时看高清视频| 香蕉人妻av久久久久天天| 老司机在线精品视频网站| 亚洲综合激情七月婷婷| 久久久久久亚洲精品| 国产中年熟女高潮大集合| 末发育娇小性色xxxxx| 又紧又黄的免费视频网站| 无码aⅴ精品一区二区三区浪潮| 九九综合九色综合网站| 女被啪到深处喷水gif动态图| 日本一卡二卡四卡无卡国产| 色婷婷一区二区三区四区成人网| 四虎亚洲欧美成人网站| 午夜免费无码福利视频| 国产高清自产拍av在线| 国产午夜福利在线播放| 亚洲欧美另类成人综合图片| 亚欧日韩欧美网站在线看| 国产精品一久久香蕉国产线看观看 | 亚洲色无码中文字幕在线| 亚洲v欧美v国产v在线观看| 成人性做爰aaa片免费看| 国产专区一线二线三线码| 伦埋琪琪久久影院三级| 国产极品美女高潮无套在线观看| 国产精品三级国产电影| 午夜高清国产拍精品| 东京热人妻丝袜无码av一二三区观 | 在线视频国产网址你懂的| 亚洲最大成人av在线天堂网| 国产女人的高潮国语对白| 亚洲a∨国产av综合av网站| 免费一区二区无码东京热| 无码人妻精品一区二区| 久久国产成人免费网站777| а√最新版在线天堂|