在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse WD repeat-containing protein 5 (Wdr5)

Recombinant Mouse WD repeat-containing protein 5 (Wdr5)

  • 中文名稱：
    小鼠Wdr5重組蛋白
  • 貨號：
    CSB-YP026038MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Wdr5重組蛋白
  • 貨號：
    CSB-EP026038MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Wdr5重組蛋白
  • 貨號：
    CSB-EP026038MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Wdr5重組蛋白
  • 貨號：
    CSB-BP026038MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Wdr5重組蛋白
  • 貨號：
    CSB-MP026038MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Wdr5
  • Uniprot No.：
  • 別名：
    Wdr5; Big; Big3WD repeat-containing protein 5; BMP2-induced 3-kb gene protein; WD repeat-containing protein BIG-3
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-334
  • 氨基酸序列
    MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH TDVVISTACHPTENIIASAALENDKTIKLWKSDC
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation. In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B.
  • 基因功能參考文獻：
    1. Cbx8 associates with non-PRC1 complexes containing the H3K4 methyltransferase complex component WDR5, which together regulate Notch gene expression. PMID: 27346354
    2. Wdr5 suppression also reduced IFNgamma, Il-1beta, and TNFalpha induced chemokine gene expression in b-cells without affecting islet-cell survival or b-cell function after 48hrs, but did begin to increase islet-cell apoptosis PMID: 26505193
    3. results suggest that specific RNAs are integral inputs into the WDR5-MLL complex for maintenance of the active chromatin state and embryonic stem cell fates PMID: 24521543
    4. Data show that broad association of myc proto-oncogene protein MYC with chromatin depends on interaction with the WD40-repeat protein WDR5. PMID: 25818646
    5. BIG3 inhibits insulin granule biogenesis and insulin secretion. PMID: 24711543
    6. BIG3 negatively regulates insulin granule exocytosis by restricting insulin granule biogenesis without the release kinetics of individual granules at the final exocytotic steps being affected. PMID: 25139048
    7. Depletion of KAT2B or WDR5 decreased gluconeogenic gene expression. PMID: 24051374
    8. analysis of a novel mechanism for epigenetic control of SMC-marker gene expression during development through interaction of WDR5, homeodomain proteins, and chromatin remodeling enzymes PMID: 21531708
    9. Study shows that WD repeat domain 5 (Wdr5), a core member of the mammalian Trithorax (trxG) complex, positively correlates with the undifferentiated state and is a regulator of ES cell self-renewal. PMID: 21477851
    10. Characterization of a novel WDR5-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 lysine 4 by mixed lineage leukemia protein-1. PMID: 20716525
    11. WDR5 is essential in assembling a virus-induced VISA-associated complex and plays an important role in virus-triggered induction of type I interferons. PMID: 20080758
    12. BIG-3 accelerates chondrocyte differentiation in vitro, and is expressed in the growth plate during embryonic development, so is is likely to play an in vivo regulatory role in the developing growth plate. PMID: 14657013
    13. identified two proteins, NONO and WDR5, that can associate with the mammalian PER1 protein; WDR5 augmented PER-mediated transcriptional repression, and its reduction by RNAi diminished circadian histone methylations at the promoter of a clock gene PMID: 15860628
    14. Wdr5 accelerates osteoblast differentiation in association with activation of the canonical Wnt pathway. PMID: 16730692
    15. Wdr5 is present on the Wnt1 promoter and on canonical Wnt response elements of the c-myc and Runx-2 promoters. PMID: 18201971
    16. Perichondrium expression of Wdr5 regulates chondrocyte proliferation and differentiation. PMID: 19217897

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    WD repeat WDR5/wds family
  • 組織特異性：
    Expressed in liver (at protein level). Detected in brain, testis and kidney.
  • 數據庫鏈接：


主站蜘蛛池模板： 一边摸一边叫床一边爽av| 亚洲男人的天堂网站| 日韩精品无码免费专区网站| 无码熟妇αⅴ人妻又粗又大| 少妇脱了内裤让我添| 日韩无码专区| 一卡二卡3卡4卡视频免费播放| 欧美精品18videos性欧美| 午夜激成人免费视频在线观看| 国产精品久久久久久久久久免费| 欧美性猛交aaaa片黑人| 国产激情久久久久影院老熟女免费| 欧美日韩精品suv| 在线黑人抽搐潮喷| 国产 亚洲 制服 无码 中文| 艳妇乳肉豪妇荡乳av| av成人无码无在线观看| 色婷婷综合久久久久中文一区二区 | 综合久久给合久久狠狠狠97色| 少妇厨房愉情理9仑片视频| 色综合视频一区中文字幕| 久久www成人影院| 伊人久久大香线蕉综合中文字幕 | 精品亚洲一区二区三区在线观看| 99久久久无码国产精品古装| 成 人 a v免费视频在线观看| 国产午夜无码片在线观看| 在线看亚洲十八禁网站| 久久精品夜色噜噜亚洲a∨| 欧美亚洲人成网站在线观看| 欧美精品人人做人人爱视频| 香蕉av777xxx色综合一区| 国产精品无码av天天爽播放器| 欧美饥渴熟妇高潮喷水| 欧美黑人激情性久久| 日日碰狠狠躁久久躁综合小说| 久久er99热精品一区二区| 免费国产成人午夜福利电影| 国产av无码专区亚洲版综合| 人妻少妇一区二区三区| 婷婷网亚洲色偷偷男人的天堂|