在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-2 (Cacna2d2), partial

  • 中文名稱:
    Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-2(Cacna2d2) ,partial
  • 貨號:
    CSB-YP757653MO
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-2(Cacna2d2) ,partial
  • 貨號:
    CSB-EP757653MO
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-2(Cacna2d2) ,partial
  • 貨號:
    CSB-EP757653MO-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-2(Cacna2d2) ,partial
  • 貨號:
    CSB-BP757653MO
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-2(Cacna2d2) ,partial
  • 貨號:
    CSB-MP757653MO
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Cacna2d2; Kiaa0558Voltage-dependent calcium channel subunit alpha-2/delta-2; Protein ducky; Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2]
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G).
  • 基因功能參考文獻:
    1. Cacna2d2 is a developmental switch that limits axon growth and regeneration. Cacna2d2 gene deletion or silencing promoted axon growth in vitro. PMID: 27720483
    2. Inner hair cells possess calcium channels that are essential for transmitting sound information into synaptic transmitter release. Voltage-gated calcium channels can coassemble with auxiliary subunit alpha2delta isoforms 1-4. We found that hair cells of the mouse express the auxiliary subunit alpha2delta2, which is needed for normal hearing thresholds. Using a mouse model with a mutant, nonfunctional alpha2delta2 prote... PMID: 27798183
    3. all of the alpha(2)delta subunits studied, alpha(2)delta-1, alpha(2)delta-2, and alpha(2)delta-3, show all of the properties expected of glycosylphosphatidylinositol-anchored proteins, both when heterologously expressed and in native tissues. PMID: 20080692
    4. We show that both mRNA and protein corresponding to this predicted transcript are expressed in du/du cerebellum and present in Purkinje cells PMID: 11756448
    5. Cacna2d2 has a role in epilepsy and ataxia PMID: 14660671
    6. In mice, targeted disruption of Cacna2d2 led to growth retardation, reduced life span, ataxia, enhanced susceptibility to seizures, and cardiac abnormalities. Cacna2d2 may be involved in hereditary cerebellar ataxias and epileptic disorders in humans. PMID: 15331424
    7. Both alpha2delta-2 and CaV2.1 are normally associated with cholesterol-rich microdomains, and this influences their functionality. PMID: 16928863

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Defects in Cacna2d2 are the cause of ducky phenotype (du). Du mice have spike-wave seizures characteristic of absence epilepsy and ataxia, with accompanying decreased calcium channel current in cerebellar Purkinje cells.
  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Calcium channel subunit alpha-2/delta family
  • 組織特異性:
    Predominantly expressed in brain in a restricted pattern. Also expressed at lower level in kidney and testis Not expressed in lung at any moment of development. In brain, it localizes to sections of P21 brain. Expressed at high level in the cerebellum, wi
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 国产麻豆精品av在线观看| 精品乱码一区二区三四五区| 国产精品99久久99久久久动漫| 粗大猛烈进出高潮视频免费看 | 国产极品白嫩精品| 久久精品囯产精品亚洲| 久久久久人妻一区精品果冻| 大地资源中文第三页| 色播亚洲视频在线观看| 国产欧美日韩另类在线专区| 国产亚洲精品久久久闺蜜| 丰满人妻被黑人猛烈进入| 最新成年女人毛片免费基地| 日韩精品一区国产偷窥在线| 欧洲亚洲色视频综合在线| 成年女人永久免费观看视频| 国产亚洲精品久久久久久久软件| 乱人伦视频中文字幕| 欧美国产日韩a在线视频下载| 国产热の有码热の无码视频| 国产精品 无码专区| 国内精品国语自产拍在线观看 | 国产人妻久久精品二区三区老狼| 俺也来俺也去俺也射| 精品久久久久久久久午夜福利| 国产传媒精品1区2区3区| 久久久久波多野结衣高潮| yy6080久久伦理一区二区| 色婷婷五月综合欧美图片| 精品一区二区三区四区五区六区| 成年丰满熟妇午夜免费视频| 国产成人无码va在线观看| 国产午夜人做人免费视频网站| 狠狠色狠狠色综合| 男女啪祼交视频| 99视频有精品视频高清| 天天天天做夜夜夜做| 国产精品免费观看久久| av中文无码乱人伦在线观看| 久久久国产精品麻豆a片| 亚洲精品少妇30p|