在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse V-type proton ATPase subunit S1 (Atp6ap1), partial

  • 中文名稱(chēng):
    Recombinant Mouse V-type proton ATPase subunit S1(Atp6ap1) ,partial
  • 貨號(hào):
    CSB-YP865645MO1
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱(chēng):
    Recombinant Mouse V-type proton ATPase subunit S1(Atp6ap1) ,partial
  • 貨號(hào):
    CSB-EP865645MO1
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱(chēng):
    Recombinant Mouse V-type proton ATPase subunit S1(Atp6ap1) ,partial
  • 貨號(hào):
    CSB-EP865645MO1-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱(chēng):
    Recombinant Mouse V-type proton ATPase subunit S1(Atp6ap1) ,partial
  • 貨號(hào):
    CSB-BP865645MO1
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱(chēng):
    Recombinant Mouse V-type proton ATPase subunit S1(Atp6ap1) ,partial
  • 貨號(hào):
    CSB-MP865645MO1
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Atp6ap1; Atp6ip1; Atp6s1; V-type proton ATPase subunit S1; V-ATPase subunit S1; Protein C7-1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; Vacuolar proton pump subunit S1
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation.
  • 基因功能參考文獻(xiàn):
    1. The mitochondrial H(+)-ATP synthase, by coupling the Warburg effect to anabolic metabolism, enables de-differentiation during the reprogramming of somatic cells to induced pluripotent stem cells. PMID: 23287468
    2. The essential role of Ac45 in osteoclast-mediated extracellular acidification and protease exocytosis, as well as the ability of Ac45 to guide lysosomal intracellular trafficking to the ruffled border, is demonstrated. PMID: 22467241
    3. propose that, in addition to its canonical function in V-ATPase-mediated acidification, Ac45 plays versatile roles during osteoclast formation and function. PMID: 22087256
    4. These results suggest that a3 V-ATPase promotes distant metastasis of B16-F10 cells by creating acidic environments via proton secretion. PMID: 21669964
    5. A point mutation within the a3 subunit, R740S, which is dominant negative for proton pumping and bone resorption, also uncouples proton pumping from ATP hydrolysis. PMID: 21305608
    6. Disruption of vacuolar H+-ATPase a3-B2 subunit interaction inhibited osteoclast bone resorption. PMID: 20837476
    7. Targeted disruption of the gene for the chromaffin granular V-ATPase-associated protein Ac45 in embryonic stem cells affects the normal blastocyst development, suggesting an essential role for the V-ATPase in early embryonic development. [AC45] PMID: 11989824
    8. In osteoclasts, the activity-dependent accumulation of acids and Ca(2+) in the closed extracellular compartment might serve as negative feedback signals for regulating the V-ATPase. PMID: 16901940
    9. cytoplasmic terminus of Ac45 contains elements necessary for its proper interaction with V(0) domain and efficient osteoclastic bone resorption PMID: 18227071
    10. role for furin in regulated secretion, particularly in intragranular acidification most likely due to impaired processing of Ac45 PMID: 18713856

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Endoplasmic reticulum membrane; Single-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane.
  • 蛋白家族:
    Vacuolar ATPase subunit S1 family
  • 組織特異性:
    Expressed in brain cortex (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接:


主站蜘蛛池模板: 成人国产精品一区二区网站公司| 国产真实乱对白精彩久久| 99久久99久久精品免费观看| 男女作爱免费网站| 成人区精品一区二区婷婷| 中文字幕av无码不卡免费| 99久久国产综合精品五月天| 精品国产av一二三四区| 中文字幕av在线一二三区| 欧美 国产 亚洲视频| 精品无码成人久久久久久| √天堂8资源中文在线| 久久久精品国产sm调教网站| 国产区又黄又硬高潮的视频| 国内自拍久久久久影院| 亚洲v欧美v国产v在线观看| 曰韩少妇内射免费播放| 国产欧美另类精品久久久| 四虎www成人影院观看| 噜噜高清欧美内射短视频| 成人艳情一二三区| 国产真实乱人偷精品视频| 日本视频免费高清一本18| 亚洲精品第一区二区三区| 久久精品国产亚洲精品| 天堂在线资源中文在线8| 亚洲国产成人精品激情姿源| 欧美丰满熟妇xxxx性ppx人交 | 亚洲s码欧洲m码国产av| 亚洲日韩在线a视频在线观看 | 国产美女在线精品免费观看| 欧美高潮喷水大叫| 中国大陆精品视频xxxx| 内射无码专区久久亚洲| 永久免费观看的毛片手机视频| 国内精品2020情侣视频| 久久精品国产亚洲7777| 7777精品久久久大香线蕉| 爆乳一区二区三区无码| 精品熟女少妇av免费久久| 国产极品美女到高潮|