在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse V-type proton ATPase subunit S1 (Atp6ap1), partial

Recombinant Mouse V-type proton ATPase subunit S1 (Atp6ap1), partial

  • 中文名稱(chēng)：
    Recombinant Mouse V-type proton ATPase subunit S1(Atp6ap1) ,partial
  • 貨號(hào)：
    CSB-YP865645MO1
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱(chēng)：
    Recombinant Mouse V-type proton ATPase subunit S1(Atp6ap1) ,partial
  • 貨號(hào)：
    CSB-EP865645MO1
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱(chēng)：
    Recombinant Mouse V-type proton ATPase subunit S1(Atp6ap1) ,partial
  • 貨號(hào)：
    CSB-EP865645MO1-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱(chēng)：
    Recombinant Mouse V-type proton ATPase subunit S1(Atp6ap1) ,partial
  • 貨號(hào)：
    CSB-BP865645MO1
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱(chēng)：
    Recombinant Mouse V-type proton ATPase subunit S1(Atp6ap1) ,partial
  • 貨號(hào)：
    CSB-MP865645MO1
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Atp6ap1; Atp6ip1; Atp6s1; V-type proton ATPase subunit S1; V-ATPase subunit S1; Protein C7-1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; Vacuolar proton pump subunit S1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation.
  • 基因功能參考文獻(xiàn)：
    1. The mitochondrial H(+)-ATP synthase, by coupling the Warburg effect to anabolic metabolism, enables de-differentiation during the reprogramming of somatic cells to induced pluripotent stem cells. PMID: 23287468
    2. The essential role of Ac45 in osteoclast-mediated extracellular acidification and protease exocytosis, as well as the ability of Ac45 to guide lysosomal intracellular trafficking to the ruffled border, is demonstrated. PMID: 22467241
    3. propose that, in addition to its canonical function in V-ATPase-mediated acidification, Ac45 plays versatile roles during osteoclast formation and function. PMID: 22087256
    4. These results suggest that a3 V-ATPase promotes distant metastasis of B16-F10 cells by creating acidic environments via proton secretion. PMID: 21669964
    5. A point mutation within the a3 subunit, R740S, which is dominant negative for proton pumping and bone resorption, also uncouples proton pumping from ATP hydrolysis. PMID: 21305608
    6. Disruption of vacuolar H+-ATPase a3-B2 subunit interaction inhibited osteoclast bone resorption. PMID: 20837476
    7. Targeted disruption of the gene for the chromaffin granular V-ATPase-associated protein Ac45 in embryonic stem cells affects the normal blastocyst development, suggesting an essential role for the V-ATPase in early embryonic development. [AC45] PMID: 11989824
    8. In osteoclasts, the activity-dependent accumulation of acids and Ca(2+) in the closed extracellular compartment might serve as negative feedback signals for regulating the V-ATPase. PMID: 16901940
    9. cytoplasmic terminus of Ac45 contains elements necessary for its proper interaction with V(0) domain and efficient osteoclastic bone resorption PMID: 18227071
    10. role for furin in regulated secretion, particularly in intragranular acidification most likely due to impaired processing of Ac45 PMID: 18713856

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane.
  • 蛋白家族：
    Vacuolar ATPase subunit S1 family
  • 組織特異性：
    Expressed in brain cortex (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接：


主站蜘蛛池模板： 免费国产乱理伦片在线观看| 国产成人综合久久亚洲精品| (无码视频)在线观看| 熟女人妻少妇精品视频| 国产人在线成免费视频| 国内自拍五区| 人妻体内射精一区二区| 老司机久久99久久精品播放| 潮喷大喷水系列无码久久精品 | 永久免费观看国产裸体美女| 老太脱裤让老头玩ⅹxxxx| 亚洲欧美日本国产专区一区| 蜜臀av国产精品久久久久| 奇米777四色影视在线看| 亚洲色大成网站www| 成人国产网站v片免费观看| 高清国产亚洲欧洲av综合一区| 国产精品高清网站| 麻豆乱码国产一区二区三区| av无码久久久久不卡蜜桃| 精品免费国偷自产在线视频| 免费人成在线观看| 国产婷婷色一区二区三区在线| 麻豆丰满少妇chinese| 久久久综合九色合综| 成人影片一区免费观看| 国产国语毛片在线看国产| 午夜成人亚洲理论片在线观看| 亚洲中文字幕无码永久在线不卡| 99久久精品日本一区二区免费| 亚洲vav在线男人的天堂 | 亚洲大尺度无码无码专线| 综合偷自拍亚洲乱中文字幕 | 久久不见久久见免费视频观看 | 纯肉无遮挡无码日本动漫| 亚洲日韩乱码中文无码蜜桃臀网站| 性欧美欧美巨大69| 国产高清狼人香蕉在线| 三级无码在钱av无码在钱| 国产丰满老熟妇乱xxx1区| 图片区小说区激情区偷拍区|