在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Ubiquitin carboxyl-terminal hydrolase 15 (Usp15), partial

Recombinant Mouse Ubiquitin carboxyl-terminal hydrolase 15 (Usp15), partial

  • 中文名稱：
    小鼠Usp15重組蛋白
  • 貨號：
    CSB-YP819200MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Usp15重組蛋白
  • 貨號：
    CSB-EP819200MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Usp15重組蛋白
  • 貨號：
    CSB-EP819200MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Usp15重組蛋白
  • 貨號：
    CSB-BP819200MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Usp15重組蛋白
  • 貨號：
    CSB-MP819200MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Usp15; Kiaa0529; Ubiquitin carboxyl-terminal hydrolase 15; EC 3.4.19.12; Deubiquitinating enzyme 15; Ubiquitin thioesterase 15; Ubiquitin-specific-processing protease 15
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal. Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B. Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy. Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery. Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9.
  • 基因功能參考文獻：
    1. In hematopoietic cells and in resident brain cells, USP15 was coexpressed with, and functionally acted together with the E3 ubiquitin ligase TRIM25 to positively regulate type I interferon responses and to promote pathogenesis during neuroinflammation. PMID: 27721430
    2. T cell intrinsic USP15 deficiency causes excessive production of IFN-gamma, which promotes an immunosuppressive tumor microenvironment during MCA-induced primary tumorigenesis. PMID: 26686633
    3. Both mouse and human have 22 exons with identical splice sites and an exon/intron structure identical to the mouse Usp4 gene. PMID: 12532266
  • 亞細胞定位：
    Cytoplasm. Nucleus. Mitochondrion.
  • 蛋白家族：
    Peptidase C19 family
  • 組織特異性：
    Widely expressed with highest levels in the brain and spleen, and lowest levels in the muscles (at protein level). In the midbrain, strong expression in neurons including the dopaminergic neurons (at protein level). Widely expressed with highest levels in
  • 數據庫鏈接：


主站蜘蛛池模板： 一本一道vs无码中文字幕| 免费精品国产人妻国语| 精品国产免费一区二区三区香蕉| 国产99久9在线视频 | 传媒| 女人爽到高潮视频免费直播| 四虎影视在线观看2413| 日产一区日产2区| 掀开奶罩边吃边摸下娇喘视频| 婷婷五月综合国产激情| 夜夜欢天天干| 好男人www社区| 亚洲综合色婷婷七月丁香| 日产2021免费一区| 艳妇荡女欲乱双飞两中年熟妇 | 无遮挡十八禁污污污网站| 一本大道伊人av久久乱码| 少妇厨房愉情理伦bd在线观看| 免费人成网视频在线观看| 无码一区二区三区av在线播放 | 国产成人 综合 亚洲欧洲| 亚州性无码不卡免费视频| 国内精品久久久久久久小说| 无码日韩人妻精品久久| 色老99久久九九爱精品| 中文字幕av无码专区第一页| 亚洲精品无码一区二区| 久久中文字幕人妻av熟女| 日本一卡2卡3卡4卡免费精品| 少妇被粗大猛进进出出| 国产精品久久久久久吹潮| 天天爽夜夜爽人人爽从早干到睌| 99久热国产精品视频尤物| 40岁成熟女人牲交片20分钟| 国产精品久久久久久久久岛| 日本少妇内射视频播放舔| 免费国产裸体美女视频全黄| 亚洲伊人色欲综合网| 奇米777四色在线精品| 无遮挡很爽很污很黄的网站| 香蕉影院在线观看| 亚洲成色最大综合在线|