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  4. Recombinant Mouse Tyrosine-protein kinase Fes/Fps (Fes), partial

Recombinant Mouse Tyrosine-protein kinase Fes/Fps (Fes), partial

  • 中文名稱：
    小鼠Fes重組蛋白
  • 貨號：
    CSB-YP008597MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Fes重組蛋白
  • 貨號：
    CSB-EP008597MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Fes重組蛋白
  • 貨號：
    CSB-EP008597MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Fes重組蛋白
  • 貨號：
    CSB-BP008597MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Fes重組蛋白
  • 貨號：
    CSB-MP008597MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Fes
  • Uniprot No.：
  • 別名：
    Fes; FpsTyrosine-protein kinase Fes/Fps; EC 2.7.10.2; Proto-oncogene c-Fes
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.
  • 基因功能參考文獻：
    1. FES is a driver of melanoma progression in a mouse model. PMID: 28463229
    2. Fes inhibition might provide therapeutic benefits in breast cancer, in part by attenuating tumor-associated angiogenesis and the metastasis-promoting functions of tumor-associated macrophages. PMID: 21159660
    3. Fes protein is activated downstream of activated Kit receptor, and this is facilitated by the Fes SH2 domain binding to Kit, and by trans-phosphorylation by Fyn kinase. PMID: 19892014
    4. Truncation of c-fes via gene targeting results in embryonic lethality and hyperproliferation of hematopoietic cells. PMID: 11977979
    5. Fes was expressed in mouse brain. Experiments with transfected mouse cDNA show that Fes links Sema3A signals to CRMP-CRAM. PMID: 12093729
    6. Fes may be a key component of the granulocyte differentiation machinery, may regulate granulocyte-specific gene expression PMID: 12584192
    7. Fps/Fes and Fer are expressed in human and mouse platelets, and are activated following stimulation with collagen and collagen-related peptide (CRP), suggesting a role in GPVI receptor signaling PMID: 12871378
    8. Hematopoiesis is deregulated in the absence of Fps and Fer kinases. Qualitative differences in myeloid colonies from compound mutant mice suggested a role for Fps and Fer kinases in regulating cell-cell adhesion or a skewing in cellularity of colonies. PMID: 12901971
    9. Fps/Fes may act synergistically with Flk1 to modulate hemangioblast differentiation into the endothelium. PMID: 14525765
    10. plays a critical role in microtubule dynamics including microtubule nucleation and bundling through its FCH domain PMID: 14551201
    11. The increased numbers and survival of erythroid progenitors from fps(MF) mice, and their differential responsiveness to SCF and EPO, implicates Fps/Fes in the commitment of multilineage progenitors to the erythroid lineage. PMID: 15504549
    12. studies suggest that Fps/Fes influences both angiogenic and hemostatic function through regulatory effects on the endothelium PMID: 15550033
    13. PEDF downregulates Fyn through Fes, resulting in inhibition of FGF-2-induced capillary morphogenesis of endothelial cells PMID: 15713745
    14. Tumor onset in a mouse model of breast epithelial cancer occurred earlier in mice targeted with either null or kinase-inactivating fps/fes mutations. PMID: 15867340
    15. Lyn and Fer/Fps kinases cooperate to phosphorylate Pecam-1 and activate Shp1/Shp2 phosphatases that function in part to limit mast cell activation PMID: 16731527
    16. These findings suggest that activation of Fes by fibroblast growth factor-2 (FGF-2) enhances FAK-dependent activation of Src within focal adhesions, promoting FGF-2-induced disassembly of focal adhesions. PMID: 16884713
    17. Fps/Fes is not essential for the maintenance of mammary epithelial cell adherens junctions in lactating mammae. PMID: 19732771

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  • 亞細胞定位：
    Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Fes/fps subfamily
  • 數(shù)據(jù)庫鏈接：


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