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  4. Recombinant Mouse Tumor necrosis factor alpha-induced protein 8 (Tnfaip8)

Recombinant Mouse Tumor necrosis factor alpha-induced protein 8 (Tnfaip8)

  • 中文名稱：
    小鼠Tnfaip8重組蛋白
  • 貨號：
    CSB-YP835637MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Tnfaip8重組蛋白
  • 貨號：
    CSB-EP835637MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Tnfaip8重組蛋白
  • 貨號：
    CSB-EP835637MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Tnfaip8重組蛋白
  • 貨號：
    CSB-BP835637MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Tnfaip8重組蛋白
  • 貨號：
    CSB-MP835637MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Tnfaip8
  • Uniprot No.：
  • 別名：
    Tnfaip8; Tumor necrosis factor alpha-induced protein 8; TNF alpha-induced protein 8
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-198
  • 氨基酸序列
    MLSEAEEPRE VATDVFNSKN LAVQAQKKIL GKMVSKSIAT TLIDDTSSEV LDELYRVTKE YTQNKKEAER VIKNLIKTVI KLAVLHRNNQ FNQDELALME KFKKKVHQLA MTVVSFHQVE YTFDRNVLSR LLNECRELLH EIIQRHLTAK SHGRVNNVFD HFSDCDFLAA LYNPFGKFKP HLQKLCDGIN KMLDEENI
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts as a negative mediator of apoptosis. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
  • 基因功能參考文獻：
    1. Study revealed that TIPE overexpression obviously augmented the volume and weight of the tumors, indicating that TIPE facilitates tumor formation probably through its antiapoptotic effect on JNK and p38 activation. PMID: 29620232
    2. TNFAIP8 expression following CLP may be associated with the pathogenesis of immune dysfunction in splenic T lymphocytes in mice. PMID: 29488604
    3. CD4+ T lymphocyte proliferative activity was significantly down-regulated when TNFAIP8 gene was silenced by siRNA in mice at 24 h post burn. Down-regulation of TNFAIP8 can significantly decrease expression levels of IL-2 and soluble IL-2R at 24 h after thermal injury. PMID: 27655497
    4. TNFAIP8 regulates RAC1 signaling during TNF-alphaR activation and L. monocytogenes invasion of cells and that this regulation is crucial for controlling cell death and lethal L. mono-cytogenes infection of mice. PMID: 25948813
    5. TIPE plays an important role in maintaining colon homeostasis and in protecting against colitis. PMID: 25948814
    6. Data indicate that mutant Tnfaip8/Oxi-alpha has been crystallized and X-ray data have been collected to 1.8 A using synchrotron radiation. PMID: 24637935
    7. Tnfaip8 expression is associated with susceptibility to Staphylococcus aureus sepsis. PMID: 20824097
    8. Data suggest that Galphai-TNFAIP8-mediated rescue of pre-oncogenic cells enhances progression to oncogenic transformation, providing a selective target to inhibit cellular transformation. PMID: 20607800
    9. Tnfaip8 is crucial in regulating glucocorticoid-mediated apoptosis of thymocytes PMID: 19730441

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    TNFAIP8 family
  • 數據庫鏈接：


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