在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Tripeptidyl-peptidase 1 (Tpp1)

Recombinant Mouse Tripeptidyl-peptidase 1 (Tpp1)

  • 中文名稱：
    小鼠Tpp1重組蛋白
  • 貨號：
    CSB-YP024113MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Tpp1重組蛋白
  • 貨號：
    CSB-EP024113MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Tpp1重組蛋白
  • 貨號：
    CSB-EP024113MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Tpp1重組蛋白
  • 貨號：
    CSB-BP024113MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Tpp1重組蛋白
  • 貨號：
    CSB-MP024113MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Tpp1; Cln2; Tripeptidyl-peptidase 1; TPP-1; EC 3.4.14.9; Lysosomal pepstatin-insensitive protease; LPIC; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase I; TPP-I
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    195-562
  • 氨基酸序列
    LHLGVT PSVLRQRYNL TAKDVGSGTT NNSQACAQFL EQYFHNSDLT EFMRLFGGSF THQASVAKVV GKQGRGRAGI EASLDVEYLM SAGANISTWV YSSPGRHEAQ EPFLQWLLLL SNESSLPHVH TVSYGDDEDS LSSIYIQRVN TEFMKAAARG LTLLFASGDT GAGCWSVSGR HKFRPSFPAS SPYVTTVGGT SFKNPFLITD EVVDYISGGG FSNVFPRPPY QEEAVAQFLK SSSHLPPSSY FNASGRAYPD VAALSDGYWV VSNMVPIPWV SGTSASTPVF GGILSLINEH RILNGRPPLG FLNPRLYQQH GTGLFDVTHG CHESCLNEEV EGQGFCSGPG WDPVTGWGTP NFPALLKTLL NP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.
  • 基因功能參考文獻：
    1. telomeres are protected from hyper-resection through the repression of the ATM and ATR kinases by TRF2 and TPP1-bound POT1a/b, respectively. PMID: 26778124
    2. Rssults suggested that CLN2, CLN3 and CLN5 genes may play an important role in early embryonal neurogenesis. PMID: 25303899
    3. demonstrated that cells expressing TIN2DeltaTPP1 instead of wild-type TIN2 phenocopy the POT1a,b knockout setting without showing additional phenotypes PMID: 25056954
    4. Gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor alpha and may have implications in late infantile Batten disease therapy PMID: 22989886
    5. TPPI activity becomes crucial for the neuronal functions later in development. PMID: 21996941
    6. Telomere protection by TPP1/POT1 requires tethering to TIN2. PMID: 22099311
    7. TPP1 protects telomere integrity and regulates telomerase recruitment to telomeres, thereby preventing early occurrence of degenerative skin pathologies. PMID: 20493811
    8. TPP1 deletion resulted in the release of POT1a and POT1b from chromatin and loss of these proteins from telomeres, indicating that TPP1 is required for the telomere association of POT1a and POT1b but not for their stability. PMID: 19995905
    9. Lysosomal degradation of cholecystokinin-(29-33)-amide in mouse brain is dependent on this enzyme: implications for the degradation and storage of peptides in classical late-infantile neuronal ceroid lipofuscinosis (tripeptidyl peptidase-I) PMID: 12038963
    10. TPP-I is the predominant proteolytic enzyme responsible for the intracellular degradation of neuromedin B PMID: 15158442
    11. The CLN2-targeted mouse recapitulates much of the pathology and clinical features of classical late-infantile neuronal ceroid lipofuscinosis PMID: 15483130
    12. Tpp1 confers telomere end protection by recruiting Pot1a and Pot1b to telomeres. Knockdown of Tpp1 elicits an ataxia telangiectasia mutated protein (ATR)-dependent DNA damage response at telomeres. PMID: 17948054
    13. Expression of 6% of normal TPPI activity increased lifespan to that of unaffected mice. PMID: 18343701
    14. Results indicate that the loss of TPPI cannot be functionally compensated for by DPPI. PMID: 18570628
    15. While all treatment groups show a marked increase in total TPP-I activity over wild-type mice, neonatally treated mice displayed high levels of TPP-I activity in the CNS 1 yr after administration which was spread throughout the brain. PMID: 18639872

    顯示更多

    收起更多

  • 亞細胞定位：
    Lysosome. Melanosome.
  • 數據庫鏈接：


主站蜘蛛池模板： 99久久国语露脸精品国产色| 精品日产一卡2卡三卡4卡在线| 免费观看性欧美大片无片| 国产精品爽爽v在线观看无码| 熟女少妇内射日韩亚洲| 免费视频爱爱太爽了| 国产av影片麻豆精品传媒| 亚洲精品乱码久久久久蜜桃| 小鲜肉自慰网站| 小嫩妇好紧好爽再快视频| 久久久精品久久日韩一区综合| 久久国内精品自在自线观看| 一卡二卡3卡四卡网站精品| 日本中文字幕在线| 精品产区wnw2544| 2020最新国产在线不卡a| 九九99久久精品在免费线18| 欧美在线精彩视频免费播放| 337p日本欧洲亚洲大胆| 国产精品扒开腿做爽爽爽视频| 国产人无码a在线西瓜影音| 亚洲制服丝袜自拍中文字幕 | 少妇av一区二区三区无码| 秋霞午夜久久午夜精品| 中国少妇大p毛茸茸| 无码人妻黑人中文字幕| 狠狠躁夜夜躁人人爽天天不卡| 亚洲国产成人久久综合碰| 国模无码一区二区三区不卡| 好了av第四综合无码久久| 久久婷婷人人澡人人爽人人爱| 国产精品自在线拍国产| 动漫精品专区一区二区三区| 日本熟妇中文字幕三级| 特级av毛片免费观看| 日韩精品一区二区三区在线观看l| 色舞月亚洲综合一区二区| 国产一区二区三区精品视频| 狠狠精品干练久久久无码中文字幕| 国产精品久久久久久免费软件| 国产欧美日韩另类精彩视频|