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  4. Recombinant Mouse Transient receptor potential cation channel subfamily M member 1 (Trpm1), partial

Recombinant Mouse Transient receptor potential cation channel subfamily M member 1 (Trpm1), partial

  • 中文名稱：
    小鼠Trpm1重組蛋白
  • 貨號：
    CSB-YP648797MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Trpm1重組蛋白
  • 貨號：
    CSB-EP648797MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Trpm1重組蛋白
  • 貨號：
    CSB-EP648797MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Trpm1重組蛋白
  • 貨號：
    CSB-BP648797MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Trpm1重組蛋白
  • 貨號：
    CSB-MP648797MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Trpm1; Ltrpc1; Transient receptor potential cation channel subfamily M member 1; Long transient receptor potential channel 1; LTrpC1; Melastatin-1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Forms nonselective divalent cation-conducting channels which mediate the influx of Na(2+), Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization. Impermeable to zinc ions. In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions. Essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. Calcium channel which may play a role in metastasis suppression. May act as a spontaneously active, calcium-permeable plasma membrane channel.
  • 基因功能參考文獻：
    1. TRPM1 and mGluR6 are both essential components in the signaling pathway. PMID: 29854741
    2. results suggest that TRPM1 channel opening is essential for rod bipolar pathway establishment in development PMID: 28899920
    3. This study confirmed the localization of LRIT3 at the dendritic tips of depolarizing bipolar cells in mouse retina and demonstrated the dependence of TRPM1 localization on the presence of LRIT3. PMID: 25997951
    4. results indicate that the serum of a patient with PR contained an antibody against TRPM1 caused an acute death of retinal ON bipolar cells of mice PMID: 24282602
    5. TRPM1 is not essential for the development of hearing or balance in the mouse model and it is unlikely that TRPM1 is the hair cell mechanotransduction channel. PMID: 24146970
    6. The data indicates that the A1068T mutant TRPM1 acts as a dominant negative with respect to TRPM1 channel function. PMID: 22896717
    7. Results suggest a model in which the Gbetagamma dimer that is released as a result of the dissociation from Galpha(o) upon activation of mGluR6 closes the TRPM1 channel, perhaps via a direct interaction. PMID: 22586107
    8. The results suggested that the TRPM1 channel in metabotropic glutamate receptor 6-null rod bipolar cells is inactive. Rod bipolar cells in metabotropic glutamate receptor 6-null mice were hyperpolarized. PMID: 22131384
    9. TRPM1 is involved in non-image-forming responses to light and may perform a functional role within photosensitive retinal ganglion cells PMID: 22211741
    10. This review describes the differential expression of TRPM1-S (short form) and -L (long form) in the mouse retina. TRPM1-L encodes a predicted 1,622 amino acid protein containing six transmembrane domains. PMID: 20846719
    11. Human TRPM1 mutations are associated with the complete form of congenital stationary night blindness in Japanese patients. PMID: 20300565
    12. These results demonstrate that TRPM1-L is a component of the ON bipolar cell (BC) transduction channel downstream of mGluR6 in ON BCs. PMID: 19966281
    13. Data suggest that TRPM1 is an ion channel whose function is critical to normal melanocyte pigmentation and is thus a potential target for pigmentation disorders. PMID: 19436059
    14. TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells. PMID: 19861548

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, axon.
  • 蛋白家族：
    Transient receptor (TC 1.A.4) family, LTrpC subfamily, TRPM1 sub-subfamily
  • 組織特異性：
    Expressed in the retina where it localizes on dendritic tips of ON bipolar cells. Specifically, it is expressed in retinal bipolar cells (BPCs) of the ON subtype. Not detected in brain, lung, liver, heart, kidney, spleen or small intestine. Also expressed
  • 數據庫鏈接：


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