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  4. Recombinant Mouse Transcription factor E2F8 (E2f8), partial

Recombinant Mouse Transcription factor E2F8 (E2f8), partial

  • 中文名稱：
    小鼠E2f8重組蛋白
  • 貨號：
    CSB-YP688365MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠E2f8重組蛋白
  • 貨號：
    CSB-EP688365MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠E2f8重組蛋白
  • 貨號：
    CSB-EP688365MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠E2f8重組蛋白
  • 貨號：
    CSB-BP688365MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠E2f8重組蛋白
  • 貨號：
    CSB-MP688365MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    E2f8
  • Uniprot No.：
  • 別名：
    E2f8Transcription factor E2F8; E2F-8
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.
  • 基因功能參考文獻：
    1. Loss of E2F8 expression is associated with tumorigenesis in liver. PMID: 29429824
    2. we identified atypical E2fs to be essential for polyploidization in the pancreas and discovered that postnatal induced loss of both atypical E2fs in many organs is compatible with life until old age PMID: 29329320
    3. E2F8-mediated transcriptional repression is a critical tumor suppressor mechanism during postnatal liver development PMID: 27454291
    4. transcription factor E2F8 is involved in the polyploidization during mouse and human decidualization PMID: 25892397
    5. Rb and E2F8 collaborate to promote DNA replication. PMID: 24865965
    6. The results identify E2F8 as a repressor and E2F1 as an activator of a transcriptional network controlling polyploidization in mammalian cells. PMID: 23064264
    7. The specificity of E2F8 in mediating Rb function in erythropoiesis suggests a critical and overlapping roles of Rb and E2f8 in maintaining normal erythropoiesis and in preventing hemolysis. PMID: 22422820
    8. Overexpression of E2F8 significantly slows down the proliferation of primary mouse embryonic fibroblasts. PMID: 15722552
    9. E2F8 may have an important role in repressing the expression of E2F-target genes in the S-phase of the cell cycle. PMID: 16179649
    10. Results identify E2F7 and E2F8 as a unique repressive arm of the E2F transcriptional network that is critical for embryonic development. PMID: 18194653

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    E2F/DP family
  • 組織特異性：
    Highly expressed in liver, skin, thymus and testis. Expressed in trophoblast giant cells throughout placenta development (at protein level).
  • 數(shù)據(jù)庫鏈接：


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