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  4. Recombinant Mouse Tapasin (Tapbp), partial

Recombinant Mouse Tapasin (Tapbp), partial

  • 中文名稱：
    小鼠Tapbp重組蛋白
  • 貨號：
    CSB-YP882620MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Tapbp重組蛋白
  • 貨號：
    CSB-EP882620MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Tapbp重組蛋白
  • 貨號：
    CSB-EP882620MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Tapbp重組蛋白
  • 貨號：
    CSB-BP882620MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Tapbp重組蛋白
  • 貨號：
    CSB-MP882620MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Tapbp; Tapa; Tapasin; TPN; TPSN; TAP-associated protein; TAP-binding protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).
  • 基因功能參考文獻：
    1. Absence of Tpn or ERAAP independently altered the peptide repertoire by causing loss as well as gain of new pMHC I. Tpn defined the characteristic carboxy termini of canonical MHC I peptides. PMID: 23863903
    2. modification of Tapasin can enhance the presentation of targeting antigens via intracellular delivery to DCs and elicit specific CTL immune responses efficiently PMID: 23299079
    3. Data show that tapasin expression is enhanced by beta 2-microglobulin via both transcriptional and post-transcriptional mechanisms. PMID: 23089196
    4. Deletion of a loop within the tapasin C-terminal Ig-like domain (Delta334-342) prevented tapasin association with the MHC class I molecule K(d). PMID: 22169163
    5. E2F1 is an essential transcription factor for tapasin. PMID: 20663889
    6. showed that a large disulfide-bonded complex was present in the mouse cells that included ERp57, tapasin, and K(d). PMID: 19687800
    7. Role of tapasin in MHC class I antigen presentation in vivo. PMID: 11774611
    8. Data show that cell surface expression of TAP-independent class I complexes is modulated by tapasin levels and is enhanced by interferon-gamma. PMID: 12202157
    9. tapasin has a essential function of tapasin in quality control of HLA-G molecules PMID: 12582157
    10. A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression. PMID: 12594855
    11. Tapasin is required for class I major histocompatibility complex (MHC-I) to bind endoplasmic reticulum-derived stabilizing peptides to achieve stability needed for alternate MHC-I processing via peptide exchange in acidic vacuolar processing compartments. PMID: 12794107
    12. Mutational analysis of tapasin provides insight into aspects of tapasin structure that are crucial to its ability to assist major histocompatibility complex class I assembly. PMID: 14978101
    13. demonstrate a key role for tapasin in shaping the MHC class I peptide repertoire, as enhancement of presentation in the presence of tapasin correlated with peptide half-life. PMID: 15286279
    14. Tapasin links class Ib molecule Qa-1b to the transporter associated with antigen processing (TAP) peptide and facilitates the delivery of Qa-1b to the cell surface. PMID: 15356116
    15. Mouse tapasin has quantitative and qualitative effects on the HLA-B*2705-bound peptide repertoire, impairing presentation of some suitable ligands and allowing others with suboptimal anchor residues and lower affinity to be presented. PMID: 15944288
    16. Essential for stable expression of the antigen-processing transmembrane domain of the TAP2 protein. PMID: 17244610
    17. A K408W mutation in the transmembrane/cytoplasmic domain disrupted K(d) folding & release from tapasin, but not interaction with TAP. The C terminus plays a role in enabling class I molecules to be expressed at the surface of mouse cells. PMID: 18958466
    18. the free cysteine 95 in mouse tapasin influences stable expression at the plasma membrane for both MHC class I allotypes, and have shown that tapasin's interaction with folded K(d) is elevated by the C95S substitution in tapasin. PMID: 19490214
    19. Tapasin editing is a contributing factor to the phenomenon of immunodominance. PMID: 19949070
    20. During the assembly of H2-M3, tapasin directly facilitates intracellular peptide binding but is not required for intracellular retention of open conformers. PMID: 11489993
    21. Tapasin is critical for loading of N-formylated peptides onto the intracellular pool of H2-M3 during the assembly of M3-peptide complexes in the endoplasmic reticulum. PMID: 11466371

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  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 數據庫鏈接：


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