Recombinant Mouse TRAF family member-associated NF-kappa-B activator (Tank)

中文名稱：

小鼠Tank重組蛋白
貨號：

CSB-YP023116MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Tank重組蛋白
貨號：

CSB-EP023116MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Tank重組蛋白
貨號：

CSB-EP023116MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Tank重組蛋白
貨號：

CSB-BP023116MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Tank重組蛋白
貨號：

CSB-MP023116MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Tank
Uniprot No.：

P70347
別名：

Tank; Itraf; TRAF family member-associated NF-kappa-B activator; TRAF-interacting protein; I-TRAF
種屬：

Mus musculus (Mouse)
蛋白長度：

Full length protein
表達區域：

1-448
氨基酸序列

MSLKRHSLRR NACHLETRAG IPTILYSDAT GQRGMDKNIG EQLNRAYEAF RQACMDRDSA VRELQQKQTE NYEQRIREQQ EQLSFQQNLI DRLKSQLLLV DSSRDNSYGY VPLLEDSDRR KNNLTLDEPH DKVKLGTLRD KQSKVRRQEV SSGKESAKGL NIPLHHERDN IEKTFWDLKE EFHRICLLAK AQKDHLSKLN IPDIATDTQC SVPIQCTDKT EKQEALFKPQ AKDDINRGMS CVTAVTPRGL GRDEEDTSFE SLSKFNVKFP PMDNDSIFLH STPEAPSILA PATPETVCQD RFNMEVRDNP GNFVKTEETL FEIQGIDPIT SAIQNLKTTD KTNPSNLRAT CLPAGDHNVF YVNTFPLQDP PDAPFPSLDS PGKAVRGPQQ PFWKPFLNQD TDLVVPSDSD SELLKPLVCE FCQELFPPSI TSRGDFLRHL NTHFNGET
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage. Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage. Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus.
基因功能參考文獻：
1. Tank, whose expression is increased during osteoclastogenesis, inhibits osteoclast formation, activity and survival, by regulating NF-kappaB activity and c-FLIP expression. PMID: 23139637
2. TANK is critical for osteoclastogenesis by regulating NF-kappaB, and is also important for proper bone remodeling. PMID: 22773835
3. role for TANK in enabling the canonical IKKs and the IKK-related kinases to regulate each other, which is required to limit the strength of TLR signaling and ultimately, prevent autoimmunity PMID: 21949249
4. MARCH5 is an authentic E3 ubiquitin ligase and catalyzes K63-linked polyubiquitination of TANK. MARCH5 modulates TLR7 signaling via releasing the inhibitory action of TANK toward TRAF6. PMID: 21625535
5. TANK may be a critical adaptor that regulates the assembly of the TANK-binding kinase 1-inducible IkappaB kinase complex with upstream signaling molecules in multiple antiviral pathways PMID: 17327220
6. constitutive TLR signaling by intestinal commensal microflora is suppressed by TANK. PMID: 19668221
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亞細胞定位：

Cytoplasm.
組織特異性：

Heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
數據庫鏈接：

KEGG: mmu:21353

STRING: 10090.ENSMUSP00000077219

UniGene: Mm.244393