在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse THO complex subunit 1 (Thoc1)

Recombinant Mouse THO complex subunit 1 (Thoc1)

  • 中文名稱：
    小鼠Thoc1重組蛋白
  • 貨號：
    CSB-YP819185MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Thoc1重組蛋白
  • 貨號：
    CSB-EP819185MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Thoc1重組蛋白
  • 貨號：
    CSB-EP819185MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Thoc1重組蛋白
  • 貨號：
    CSB-BP819185MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Thoc1重組蛋白
  • 貨號：
    CSB-MP819185MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Thoc1
  • Uniprot No.：
  • 別名：
    Thoc1; Hpr1; THO complex subunit 1; Tho1; Nuclear matrix protein p84
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-657
  • 氨基酸序列
    MSPTPALFSL PEARTRFTKS TREALNNKNI KPLLTAFSQL PGSENEKKCT LDQAFRGVLE EEIINHSACE NVLAIISLAI GGVTESVCTA STPFVLLGDV LDCLPLDQCD TIFTFVEKNV ATWKSNTFYS AGKNYLLRMC NDLLRRLSKS QNTVFCGRIQ LFLARLFPLS EKSGLNLQSQ FNLENVTVFN TNEQESTLGQ KHTEDREEGM DVEEGEMGDD EAPTTCSIPI DYNLYRKFWS LQDYFRNPVQ CYEKISWKTF LKYSEEVLAV FKSYKLDDTQ ASRKKMEELK TGGEHVYFAK FLTSEKLMDL QLSDSNFRRH ILLQYLILFQ YLKGQVKFKS SNYVLTDEQS LWIEDTTKSV YQLLSENPPD GERFSKMVEH ILNTEENWNS WKNEGCPSFV KERASDTKPT RVVRKRAAPE DFLGKGPNKK ILIGNEELTR LWNLCPDNME ACKSETREYM PTLEEFFEEA IEQADPENMV ESEYKAVNNS NYGWRALRLL ARRSPHFFQP TNQQFKSLPE YLENMVIKLA KELPPPSEEI KTGEDEDEED NDALLKENES PDVRRDKPIT GEQIESFANK LGEQWKILAP YLEIKDSDIR QIECDSEDMK MRAKQLLVAW QDQEGVHATT DNLISALNKS GLSDLAESLT NDTETNS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation.; Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1. Essential for early embryonic development. Required for normal gene expression during postnatal testis development.
  • 基因功能參考文獻：
    1. Results found that Thoc1 deficiency delays embryo death, and suggest that Thoc1 is required to support increased expression of E2f and apoptotic regulatory genes that trigger apoptosis upon Rb1 loss. PMID: 27001308
    2. granulocyte macrophage progenitors have a cell autonomous requirement for Thoc1 to maintain cell growth and viability PMID: 24830368
    3. Thoc1 gene deletion prevents prostate cancer progression in mice, but has little effect on normal tissue. Prostate cancer cells deprived of Thoc1 show gene expression defects that compromise cell growth. PMID: 25296641
    4. Thoc1 loss compromises the proliferation and lineage-generating capacity of small intestinal stem cells, disrupting the supply of differentiated cells in this rapidly renewing tissue. PMID: 23816884
    5. This suggests NEDD4-1 functions in conjunction with other post-translational mechanisms to regulate Thoc1 protein and THO activity. PMID: 23460917
    6. results demonstrate that NO-mediated thoc1 downregulation, via Nrf2, is a key step in the cancer cell apoptosis induced by CCL-34-treated macrophages PMID: 23688498
    7. The generation and phenotypic characterization of mice containing a null allele of the Thoc1 gene is described. PMID: 16705185
    8. These findings support the notion that Thoc1-mediated RNP assembly contributes to the coordinated expression of genes necessary for normal differentiation and development in vivo. PMID: 19307311

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus speckle. Nucleus, nucleoplasm. Nucleus matrix. Cytoplasm.
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲精品卡2卡3卡4卡5卡区| 成人精品一区二区三区在线观看| 欧美精品色婷婷五月综合| 人妻巨大乳hd免费看| 粗了大了 整进去好爽视频| 国产一区二区三区在线蜜桃| 99久久婷婷国产一区二区| 日韩av片无码一区二区不卡电影 | 特大巨黑吊xxxx高潮| 欧美大屁股xxxx高跟欧美黑人| 亚洲欧美国产成人综合欲网| 欧美变态另类牲交| 无码国内精品久久综合88| 老熟妇高潮一区二区三区| 亚洲性色av一区二区三区| 亚洲超碰无码色中文字幕97| 中文字幕亚洲码在线观看| 最新精品香蕉在线| 岛国片人妻三上悠亚| 欧美日本亚洲韩国一区| 精品一卡2卡三卡4卡免费网站| 激情久久av一区av二区av三区 | 亚洲系列一区中文字幕| 特级毛片全部免费播放| 嫩草av久久伊人妇女超级a| 真人做人试看60分钟免费| 丁香五月开心婷婷激情综合| 在线观看片免费人成视频无码| 中文成人无字幕乱码精品区| 久久久受www免费人成| 97性无码区免费| 太粗太深了太紧太爽了动态图男男| 精品国产人妻一区二区三区| 亚洲国产另类久久久精品黑人| 99国产成人精品视频| 97在线观看永久免费视频| 中文字幕日韩精品一区二区三区| 2021久久精品国产99国产精品| 波多野av一区二区无码| 国产精品白浆一区二小说| 亚洲女教师丝祙在线播放|