在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse T-box brain protein 1 (Tbr1)

Recombinant Mouse T-box brain protein 1 (Tbr1)

  • 中文名稱：
    小鼠Tbr1重組蛋白
  • 貨號：
    CSB-YP717539MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Tbr1重組蛋白
  • 貨號：
    CSB-EP717539MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Tbr1重組蛋白
  • 貨號：
    CSB-EP717539MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Tbr1重組蛋白
  • 貨號：
    CSB-BP717539MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Tbr1重組蛋白
  • 貨號：
    CSB-MP717539MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Tbr1
  • Uniprot No.：
  • 別名：
    Tbr1; T-box brain protein 1; T-brain-1; TBR-1; TES-56
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-681
  • 氨基酸序列
    MQLEHCLSPS IMLSKKFLNV SSSYPHSGGS ELVLHDHPII STTDNLERSS PLKKITRGMT NQSDTDNFPD SKDSPGDVQR SKLSPVLDGV SELRHSFDGS AADRYLLSQS SQPQSAATAP SAMFPYPSQH GPAHPAFSIG SPSRYMAHHP VITNGAYNSL LSNSSPQGYP TAGYPYPQQY GHSYQGAPFY QFSSTQPGLV PGKAQVYLCN RPLWLKFHRH QTEMIITKQG RRMFPFLSFN ISGLDPTAHY NIFVDVILAD PNHWRFQGGK WVPCGKADTN VQGNRVYMHP DSPNTGAHWM RQEISFGKLK LTNNKGASNN NGQMVVLQSL HKYQPRLHVV EVNEDGTEDT SQPGRVQTFT FPETQFIAVT AYQNTDITQL KIDHNPFAKG FRDNYDTIYT GCDMDRLTPS PNDSPRSQIV PGARYAMAGS FLQDQFVSNY AKARFHPGAG AGPGPGTDRS VPHTNGLLSP QQAEDPGAPS PQRWFVTPAN NRLDFAASAY DTATDFAGNA ATLLSYAAAG VKALPLQAAG CTGRPLGYYA DPSGWGARSP PQYCGAKSGS VLPCWPNSAA AAARMAGANP YLGEEAEGLA AERSPLAPAA EDAKPKDLSD SSWIETPSSI KSIDSSDSGI YEQAKRRRIS PADTPVSESS SPLKSEVLAQ RDCEKNCAKD IGGYYGFYSH S
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection. As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons.
  • 基因功能參考文獻：
    1. Study induced neuronal differentiation of mouse bone mesenchymal stem cells (bMSCs) into neuron-like cells in vitro. miR-122-5p was well complementary with the target site of Tbr1 mRNA3'UTR and could inhibit Tbr1 expression by binding to its 3'UTR. Expressions of Tbr1 mRNA and protein were decreased. Overexpression of miR-122-5p downregulated the expressions of Tbr1, NSE, and TAU. PMID: 28240720
    2. CASK T740A mutation attenuated the interaction between CASK and TBR1 in the brain. However, CASK T740A mice were generally healthy, without obvious defects in brain morphology. The most dramatic defect among the mutant mice was in extinction of associative memory, though acquisition was normal. PMID: 28234597
    3. Mice lacking Tbr1 have Ca2+ waves in the cortex at normal frequencies and with normal neurotransmitter dependencies. PMID: 26473411
    4. Our findings highlight a TBR1-regulated network of autism spectrum disorders genes in the developing neocortex that are relatively intolerant to loss-of-function mutations, indicating that these genes may play critical roles in normal cortical development. PMID: 27325115
    5. T-Brain-1 (TBR1), a causative gene in autism spectrum disorders (ASDs), encodes a brain-specific T-box transcription factor. PMID: 25600067
    6. trans-synaptic Zn mobilization by clioquinol, a Zn chelator and ionophore, rescues the social interaction deficits in Shank2-/- and Tbr1+/- mice PMID: 25981743
    7. Transgenic overexpression of Wnt7b decreased expression of Tbr1 in both progenitor cells and post-mitotic neurons. PMID: 24953933
    8. This study demonistrated that Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality. PMID: 24441682
    9. Results show that the expression of Tbr1 in neural stem and progenitor cells prevents them from following an astrocyte fate during olfactory bulb development. PMID: 20807572
    10. TBR1 is a direct transcriptional repressor of Fezf2 and a negative regulator of CS tract formation that restricts the laminar origin of CS axons specifically to L5. PMID: 21285371
    11. TBR1 promotes the identity of corticothalamic neurons and represses subcerebral fates through reducing expression of Fezf2 and CTIP2. PMID: 21228164
    12. Tbr1 coordinately regulates regional and laminar identity of postmitotic cortical neurons. PMID: 20615956
    13. Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex PMID: 20348416
    14. While Tbr1 is expressed in postmitotic neurons, Tbr2 (which is also expressed during gastrulation) is also expressed in neural progenitors. PMID: 12128215
    15. We suggest that Tbr-1/CASK protein complex regulates expression of these downstream target genes and thus modulates neuronal activity and function. PMID: 15584924
    16. These findings delineate the transcription factor sequence Pax6 --> Tbr2 --> Tbr1 in the differentiation of radial glia --> intermediate progenitor cell --> postmitotic projection neuron. PMID: 15634788
    17. Here, we provide a tool to illuminate a unique subset of SP and deep CP neurons: expression of a Tbrain-1 (Tbr1)-driven transgene. PMID: 16188453
    18. Tbr1 gene is expressed in cells that interact with olfactory sensory neurons PMID: 17506891
    19. Taken together, our data illustrate that Ngn2, neuroD and Tbr transcription factors are involved in postnatal neurogenesis in the olfactory bulb. PMID: 19200230

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in the developing and adult cortex. Expressed in the olfactory bulbs.
  • 數據庫鏈接：


主站蜘蛛池模板： 884aa四虎影成人精品| 人妻熟女av一区二区三区| 国产福利自产拍| 国产精品扒开腿做爽爽爽a片唱戏| 99噜噜噜在线播放| 精品人妻伦九区久久aaa片69| 国产一区二区三区在线电影| 亚洲 欧美 国产 动漫 综合| 久久无码人妻影院| 老熟妻内射精品一区| 欧美一性一乱一交一视频| 看国产一毛片在线看手机看| 国产亚洲精品在av| 私人毛片免费高清影视院| 白丝美女被狂躁免费视频网站| 亚洲综合天堂一区二区三区 | 国语自产拍在线视频中文| 亚洲另类激情专区小说| 色135综合网| 人人玩人人添人人澡超碰偷拍 | 黑人大荫蒂老太大| 国产精品制服| 秋霞国产精品一区二区| 国产99在线 | 欧美| 日本熟妇色xxxxx日本免费看| 免费无码成人av电影在线播放 | 亚洲国产美女精品久久久久∴| 日本一道本高清一区二区| 中文字幕无码家庭乱欲 | 无码人妻精品一区二 | 国产精品福利一区二区久久| 亚洲日韩中文字幕无码一区 | 国产乱人伦偷精精品视频| 国产精品免费精品自在线观看| 99久久国产精品免费高潮| 久热爱精品视频线路一| 人妻av中文系列| 中文字幕一区二区三区精华液| 青草草97久热精品视频| 日日鲁鲁鲁夜夜爽爽狠狠视频97| 精品国内自产拍在线观看视频|