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  4. Recombinant Mouse Syntaxin-11 (Stx11)

Recombinant Mouse Syntaxin-11 (Stx11)

  • 中文名稱：
    小鼠Stx11重組蛋白
  • 貨號：
    CSB-YP871974MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Stx11重組蛋白
  • 貨號：
    CSB-EP871974MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Stx11重組蛋白
  • 貨號：
    CSB-EP871974MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Stx11重組蛋白
  • 貨號：
    CSB-BP871974MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Stx11重組蛋白
  • 貨號：
    CSB-MP871974MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Stx11
  • Uniprot No.：
  • 別名：
    Stx11; Syntaxin-11
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-287
  • 氨基酸序列
    MKDRLAELQE LSRSYDQQFP DGDNDFDAPR EDIVFETDNI LESLYRVIQD IQDENQLLLI DVRRLGRQNV RFLTSMRRLS SIKRDTNSIA KAIKTRGEGI HQKLRSMKEL SEQAEARHGA HSAVARISHA QYSALARAFQ QAMYEYNQAE MKQRDNCKIR IQRQLEIMGK DMSGEQIEDM FEQGKWDVFS ENLLADLKGA RAALNEIESR HRELLRLEGR IRDVHELFLQ MAVLVEKQED TLNVIELNVQ KTLDYTGEAK AQVRKAVQYK KKNPCRTICC FCCPCVN
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
  • 基因功能參考文獻：
    1. required for NK and CD8+ T cell cytotoxicity and neutrophil degranulation PMID: 23042080
    2. Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11. PMID: 23160464
    3. Blockade of inhibitory receptors on T cells in Stx11-deficient mice converted nonfatal disease course into fatal HLH, identifying T-cell exhaustion as an important factor for determination of disease severity in hemophagocytic lymphohistiocytosis. PMID: 23190531
    4. Results suggest that by regulating the availability of Vti1b, Stx11 regulates trafficking steps between late endosomes, lysosomes and the cell surface in macrophages. PMID: 21388490
    5. Stx11 were highly expressed at the end of fetal development but downregulated at 4 and 11 weeks in brain, pancreas, and heart. PMID: 19169743

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  • 亞細胞定位：
    Membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
  • 蛋白家族：
    Syntaxin family
  • 數據庫鏈接：


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