在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Stress-induced-phosphoprotein 1 (Stip1)

Recombinant Mouse Stress-induced-phosphoprotein 1 (Stip1)

  • 中文名稱：
    小鼠Stip1重組蛋白
  • 貨號：
    CSB-YP022831MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Stip1重組蛋白
  • 貨號：
    CSB-EP022831MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Stip1重組蛋白
  • 貨號：
    CSB-EP022831MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Stip1重組蛋白
  • 貨號：
    CSB-BP022831MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Stip1重組蛋白
  • 貨號：
    CSB-MP022831MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Stip1
  • Uniprot No.：
  • 別名：
    Stip1; Stress-induced-phosphoprotein 1; STI1; mSTI1; Hsc70/Hsp90-organizing protein; Hop
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-543
  • 氨基酸序列
    MEQVNELKEK GNKALSAGNI DDALQCYSEA IKLDPQNHVL YSNRSAAYAK KGDYQKAYED GCKTVDLKPD WGKGYSRKAA ALEFLNRFEE AKRTYEEGLK HEANNLQLKE GLQNMEARLA ERKFMNPFNL PNLYQKLEND PRTRSLLSDP TYRELIEQLQ NKPSDLGTKL QDPRVMTTLS VLLGVDLGSM DEEEEAATPP PPPPPKKEPK PEPMEEDLPE NKKQALKEKE LGNDAYKKKD FDKALKHYDR AKELDPTNMT YITNQAAVHF EKGDYNKCRE LCEKAIEVGR ENREDYRQIA KAYARIGNSY FKEEKYKDAI HFYNKSLAEH RTPDVLKKCQ QAEKILKEQE RLAYINPDLA LEEKNKGNEC FQKGDYPQAM KHYTEAIKRN PRDAKLYSNR AACYTKLLEF QLALKDCEEC IQLEPTFIKG YTRKAAALEA MKDYTKAMDV YQKALDLDSS CKEAADGYQR CMMAQYNRHD SPEDVKRRAM ADPEVQQIMS DPAMRLILEQ MQKDPQALSE HLKNPVIAQK IQKLMDVGLI AIR
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90.
  • 基因功能參考文獻：
    1. In conclusion, STIP1 is upregulated in HCC and associated with poor clinical prognosis. Blocking STIP1 activity suppresses HCC cell growth, providing the rationale for STIP1 as a potential therapeutic target in HCC. PMID: 28887036
    2. Domains of STIP1 responsible for regulating PrPC-dependent amyloid-beta oligomer toxicity PMID: 27208175
    3. Reduced STIP1 levels can contribute to phenotypes related to hyperactivity and attention deficits. PMID: 26398952
    4. We correlate the expression of STI1 and glioma progression, and suggest that STI1 expression in microglia/macrophages and infiltrating lymphocytes is modulated by the brain tumor microenvironment. PMID: 25042352
    5. Knockdown of PIAS1 in astrocytes impairs the accumulation of nuclear STI1 in response to irradiation. Moreover, a PIAS1 mutant lacking the STI1 binding site is unable to increase STI1 nuclear retention. PMID: 23938469
    6. stress-inducible protein-1 has a role in recruitment of bone marrow derived cells into the ischemic brains PMID: 23836498
    7. Our findings reveal a previously unrecognized role of the PrP(C) ligand STI1 in protecting neurons in Alzheimer disease and suggest a novel pathway that may help to offset AbetaO-induced toxicity. PMID: 24133259
    8. Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein. PMID: 23729591
    9. STI1 and laminin-gamma1 promote robust axonogenesis in wild-type dorsal root ganglia neurons; STI1 promotes extracellular calcium influx. PMID: 23145988
    10. Neuroprotection and neuritogenesis mediated by PrP(C)-STI1 engagement are dependent upon the increased protein synthesis mediated by PI3K-mTOR signaling. PMID: 20615969
    11. evaluated the temporal expression pattern of STI1 and Vn and their colocalization with their ligand PrPC, demonstrated that PrPC, STI1, and Vn are coexpressed in most of the embryonic tissues evaluated. PMID: 19760599
    12. Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection. The interaction sites were mapped to amino acids 113-128 from PrP(c) and 230-245 from STI1. Both proteins are associated in vivo. PMID: 12093732
    13. mSTI1 has a specific tetratricopeptide repeat motif that enables it to bind to HSC70 PMID: 12482845
    14. first evidence of nuclear import and export of major Hsp70/Hsp90 co-chaperone mSTI1, and the regulation of this nuclear-cytoplasmic shuttling by cell cycle status and cell cycle kinases PMID: 14754904
    15. These data are consistent with results established with a model where OR and N-terminal half of the HR mediate the action of STI1 upon cell survival and upregulation of SOD activity. PMID: 15670743
    16. Stress-inducible protein 1 added to hippocampal cultures interacts with cellular prion protein (PrPc) and elicits neuritogenesis in wild-type neurons, but not PrPc-null cells. PMID: 16339028
    17. This suggests an important role for Stip1 in the ability of germ cells to survive in stress conditions including high temperatures. PMID: 16894550
    18. Hop may be cleaved by GzmB as an "innocent bystander" during the induction of apoptosis, but it may also act to facilitate apoptosis in concert with other GzmB substrates PMID: 17005566
    19. Hop/STI1 can modulate both proliferation and cell death in the developing retina independent of PrP(C). PMID: 17651690
    20. These results show that PrP(C) endocytosis is a necessary step to modulate STI1-dependent ERK1/2 signaling involved in neuritogenesis. PMID: 18579743
    21. our data show that PrP(C) and STI1 are essential to astrocyte development and act through distinct signaling pathways. PMID: 19243016

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus. Dynein axonemal particle.
  • 數據庫鏈接：


主站蜘蛛池模板： 欧美野性肉体狂欢大派对 | 色综合天天综合高清网国产在线| 久久久99精品成人片 | 国产婷婷色一区二区三区 | 强辱丰满人妻hd中文字幕| 蜜桃日本免费观看mv| 色噜噜噜亚洲男人的天堂| 日韩av午夜在线观看| 国产绳艺sm调教室论坛| 狠狠躁夜夜躁无码中文字幕| 精品丝袜国产自在线拍小草| 免费无码又爽又刺激聊天app | 人与动人物xxxx毛片| 18禁白丝喷水视频www视频| 国产成人综合欧美精品久久| 男人猛戳女人30分钟视频大全| 浪货趴办公桌～h揉秘书电影| 日韩大片高清播放器| 无翼乌工口肉肉无遮挡无码18| 亚洲无人区午夜福利码高清完整版| av大尺度一区二区三区| 国产二级一片内射视频插放| 337p日本欧洲亚洲大胆色噜噜| 日本xxxx色视频在线观看| 最新777第四色米奇影视| 久久久久久成人毛片免费看| 久久久受www免费人成| 国产欧美日韩综合在线成| 果冻传媒18禁免费视频| 国产一区二区不卡老阿姨| 国产aⅴ精品一区二区三区尤物 | 99日本精品永久免费久久| 欧美激欧美啪啪片| 精品久久久久久久久久久aⅴ | 欧美性群另类交| 欧美亚洲国产片在线播放| 婷婷五月综合色视频| 欧美日激情日韩精品嗯| 少妇大叫太大太爽受不了| 窝窝午夜精品一区二区| 国产丝袜在线精品丝袜不卡|