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  4. Recombinant Mouse Stathmin-2 (Stmn2)

Recombinant Mouse Stathmin-2 (Stmn2)

  • 中文名稱：
    小鼠Stmn2重組蛋白
  • 貨號：
    CSB-YP022858MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Stmn2重組蛋白
  • 貨號：
    CSB-EP022858MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Stmn2重組蛋白
  • 貨號：
    CSB-BP022858MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Stmn2重組蛋白
  • 貨號：
    CSB-MP022858MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Stmn2; Scg10; Scgn10; Stmb2; Stathmin-2; Superior cervical ganglion-10 protein; Protein SCG10
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-179
  • 氨基酸序列
    MAKTAMAYKE KMKELSMLSL ICSCFYPEPR NINIYTYDDM EVKQINKRAS GQAFELILKP PSPISEAPRT LASPKKKDLS LEEIQKKLEA AEERRKSQEA QVLKQLAEKR EHEREVLQKA LEENNNFSKM AEEKLILKME QIKENREANL AAIIERLQEK ERHAAEVRRN KELQVELSG
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone.
  • 基因功能參考文獻：
    1. autophagy induction stabilized microtubules by degrading SCG10, a microtubule disassembly protein in neurons. In mice with spinal cord injury, local administration of a specific autophagy-inducing peptide, Tat-beclin1, to lesion sites markedly attenuated axonal retraction of spinal dorsal column axons and cortical spinal tract and promoted regeneration of descending axons following long-term observation PMID: 27638205
    2. SCG10 promotes non-amyloidogenic processing of amyloid precursor protein by facilitating its trafficking to the cell surface. PMID: 23863461
    3. This study demonstrated that axonal injury induces a dynamic regulation of SCG10 protein levels with selective accumulation in proximal axon segments. PMID: 24246279
    4. JNK phosphorylation targets SCG10 for degradation. PMID: 23188802
    5. SCG10 is not directly implicated in Hirschsprung diseased evelopment PMID: 21187955
    6. the Rarb region of Mmu14 and Stmn2, but not Cr1 or Clu or Picalm have roles in prion disease PMID: 21151910
    7. These findings indicate that the phosphorylation of SCG10 by JNK1 is a fundamental mechanism that governs the transition from the multipolar stage and the rate of neuronal cell movement during cortical development. PMID: 21297631
    8. KBP binds exclusively to microtubule associated or related proteins, specifically SCG10. PMID: 20621975

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  • 亞細胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Cell projection, axon. Membrane; Peripheral membrane protein; Cytoplasmic side. Endosome. Golgi apparatus. Cell projection, lamellipodium.
  • 蛋白家族：
    Stathmin family
  • 組織特異性：
    Neuron specific.
  • 數據庫鏈接：


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