Recombinant Mouse Sodium/potassium-transporting ATPase subunit alpha-1 (Atp1a1), partial

^{In Stock}

貨號：

CSB-EP851831MO
規格：

￥2328
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

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靶點詳情

產品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
基因名：

Atp1a1
Uniprot No.：

Q8VDN2
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
來源：

E.coli
分子量：

53.3 kDa
表達區域：

341-775aa
氨基酸序列

TVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWFALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIEVCCGSVMEMREKYSKIVEIPFNSTNKYQLSIHKNPNASEPKHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLLLPDEQFPEGFQFDTDDVNFPVDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVNQVNPRDAKACVVHGSDLKDMTSEELDDILRYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIVGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
基因功能參考文獻：
1. An antibody against the extracellular DR region (897-911) of Na(+)-K(+)-ATPase subunit alpha 1 disrupted the Na+-K+-ATPase/ROS amplifier and protected embryonic hearts in organ culture from ROS-induced injury and apoptosis. PMID: 28181111
2. Cardiotonic steroids activate NF-kappaB leading to proinflammatory cytokine production in primary macrophages through a signaling complex, including CD36, TLR4, and Na/K-ATPase. PMID: 28619997
3. Study identified the Na+/K+-ATPase alpha 1 and 3 subunits as receptors for the extracellular fragment of GPNMB that mediates activation of cellular signaling pathways and subsequent neuroprotective effects. PMID: 26988030
4. effects of endogenous acetylcholine on alveolar fluid clearance are likely mediated by Na,K-ATPase function through activation of muscarinic acetylcholine receptors on alveolar epithelia PMID: 26134533
5. Oxidized LDL-bound CD36 recruits an Na/K-ATPase-Lyn complex in macrophages that promotes atherosclerosis. PMID: 26350901
6. TGFbeta1 is a powerful regulator of megakaryocytic Na+/K+ ATPase activity. PMID: 25168590
7. Inhibition of the Na+/K+-ATPase pathway in astrocytes leads to rearrangement of cytoskeleton. PMID: 24095695
8. Reduction of Na/K-ATPase affects cardiac remodeling and increases c-kit cell abundance in partial nephrectomized mice. PMID: 24748592
9. Enhanced Na+ entry did not alter Na,K-ATPase a1 mRNA level in tranfected mCDD cells. Post-transcriptional control of Na,K-ATPase abundance is effected by lysosomal degradation. PMID: 24179170
10. This coupling of astrocytic A2ARs to the regulation of glutamate transport through modulation of NKA-alpha2 activity provides a novel mechanism linking neuronal activity to ion homeostasis controlling glutamatergic activity. PMID: 24259572
11. Concurrent impairment of Na(+)+K(+)-ATPase function in multi-organ may serve as one of the molecular pathways participating in and contributing to the mechanism of type-1 diabetes-induced complications in NOD mice. PMID: 22906552
12. Activation of Na,K-ATPase protects against oxidative damage in an animal model of pentylenetetrazol-induced seizures. PMID: 23219656
13. The results reveled that the NKAalpha1 subunit is found within alpha-motoneurons of spinal cord. PMID: 23761886
14. Reduction of Na+, K+-ATPase activity and expression in cerebral cortex of glutaryl-CoA dehydrogenase deficient mice is a possible mechanism for brain injury in glutaric aciduria type I. PMID: 22999741
15. Results indicate that Activation of Na+,K+-ATPase in skeletal muscle cells is AMPK-dependent. PMID: 22610379
16. the sodium pump alpha1 sub-unit has a role in progression of metastatic melanoma PMID: 19243476
17. ATP1A1 interaction with PKCeta and occludin was involved in the integrity of the blood-labyrinth-barrier PMID: 21304972
18. Both protein and mRNA expression of alpha1 and alpha2 isoforms of Na,K-ATPase and NKCC1 in the lateral wall were dramatically reduced following a long-term deafening PMID: 21094218
19. Functional coupling between the vascular alpha2 Na(+) pump and NCX1 is a critical molecular mechanism for salt-induced blood pressure elevation. (review) PMID: 21048395
20. Konjac polysaccharide could decrease body weight, postprandial blood glucose, serum leptin and intestinal mucosa Na -K+-ATPase activity of mice treated with high fat. PMID: 19408668
21. Alpha(1) isoform is expressed at more constant levels in both diaphragm and hindlimb muscles. PMID: 12397396
22. Mouse embryos homozygous for a null mutation in the Na/K-ATPase alpha1-subunit gene are able to undergo compaction and cavitation PMID: 15147760
23. results demonstrate that the Na,K-ATPase alpha 1 isoform regulates cardiac contractility and is functionally and physically coupled with the Na/Ca exchanger in heart PMID: 15485817
24. identification of groups of genes whose expressions were perturbed in the alpha1 heterozygous hearts compared to wild-type PMID: 15706699
25. The results indicate that the Na(+)/K(+)-ATPase is a potent regulator of tight junction formation and function during mouse preimplantation development. PMID: 16356488
26. identified a well conserved Na,K-ATPase catalytic alpha-subunit motif that binds to the inositol 1,4,5-trisphosphate receptor and can trigger an anti-apoptotic calcium signal. PMID: 16723354
27. Tubuloglomerular feedback requires activity of the alpha1 Na,K-ATPase, presumably in the macula densa. Furthermore, the data show that neither NHE2 nor colonic H,K-ATPase is essential for initiation of TGF responses[Na,K-ATPase alpha1] PMID: 16870707
28. while ATP1A3-isoforms regulate sodium and potassium homeostasis in subicular interneurones, ATP1A1-isoforms assume this function in pyramidal cells PMID: 17947306
29. This study provides a new link between alteration of sodium pump activity and hypertension in vivo, and suggests that TCTP might be a therapeutic target for the treatment of hypertension. PMID: 17976639
30. studies of the behavioral aspects of alpha1, alpha2, and alpha 3 deficient mice show that haploinsufficiency of both alpha2 and alpha 3 isoforms result in behavioral defects. PMID: 18044013
31. Examine roles of NCX1 and Atp1a1 in phospholamban regulation of cardiomyocyte contractility. PMID: 18708446
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亞細胞定位：

Basolateral cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma; Multi-pass membrane protein. Cell projection, axon. Melanosome.
蛋白家族：

Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIC subfamily
數據庫鏈接：

KEGG: mmu:11928

STRING: 10090.ENSMUSP00000039657

UniGene: Mm.193670