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  1. 首頁(yè)
  2. 蛋白
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  4. Recombinant Mouse Sodium channel modifier 1 (Scnm1)

Recombinant Mouse Sodium channel modifier 1 (Scnm1)

  • 中文名稱：
    小鼠Scnm1重組蛋白
  • 貨號(hào)：
    CSB-YP020847MO
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Scnm1重組蛋白
  • 貨號(hào)：
    CSB-EP020847MO
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Scnm1重組蛋白
  • 貨號(hào)：
    CSB-EP020847MO-B
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Scnm1重組蛋白
  • 貨號(hào)：
    CSB-BP020847MO
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Scnm1重組蛋白
  • 貨號(hào)：
    CSB-MP020847MO
  • 說(shuō)明書(shū)：
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Scnm1
  • Uniprot No.：
  • 別名：
    Scnm1; Scnm1-ps; Sodium channel modifier 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-229
  • 氨基酸序列
    MSFKREGDDW SQLNVLKKRR VGDLLASYIP EDEALMLRDG RFACAICPHR PVLDTLAMLT AHRAGKKHLS SLKLFYGKKQ TGKGTEQNPR QQNELKTESK TEAPLLTQTR IITQNALHRA PHYNSCCRRK HRPEAPAPSV SSPPLPTAEV QLQSAEISKE PEPRERSDAK ESAALLASAP MSPTKRRVLN HYLTLRSSGW VPDGRGRWIK DENVEFDSDE EEPPDLPLD
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.
  • 基因功能參考文獻(xiàn)：
    1. Variation between inbred strains of mice can be used to identify modifier genes affecting the susceptibility to inherited disease. The severity of the neurological disorder is determined by the modifier locus Scnm1. PMID: 13679025
    2. Scnm1 is the first example of a modifier gene which influences disease severity through a trans-effect on splicing of the disease gene transcript. PMID: 17656373
  • 相關(guān)疾病：
    Allele R187X is a disease susceptibility variant, which modifies the severity of the disease jolting mutant (medjo) caused by defects in Scn8a. It reduces the abundance of correctly spliced Scn8a transcripts below the threshold for survival thereby converting a chronic movement disorder into a lethal neurological disease.
  • 亞細(xì)胞定位：
    Nucleus, nucleoplasm. Nucleus speckle.
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: mmu:69269

    UniGene: Mm.182944



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