在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog (Smcr8), partial

Recombinant Mouse Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog (Smcr8), partial

  • 中文名稱：
    小鼠Smcr8重組蛋白
  • 貨號：
    CSB-YP661046MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Smcr8重組蛋白
  • 貨號：
    CSB-EP661046MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Smcr8重組蛋白
  • 貨號：
    CSB-EP661046MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Smcr8重組蛋白
  • 貨號：
    CSB-BP661046MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Smcr8重組蛋白
  • 貨號：
    CSB-MP661046MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Smcr8
  • Uniprot No.：
  • 別名：
    Smcr8; Guanine nucleotide exchange protein SMCR8; Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates. In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes.
  • 基因功能參考文獻：
    1. C9ORF72 and SMCR8 have interdependent functions in suppressing autoimmunity as well as negatively regulating lysosomal exocytosis-processes of potential importance to amyotrophic lateral sclerosis. PMID: 29950492
    2. We created Smcr8 knockout mice and found that Smcr8 mutant cells exhibit impaired autophagy induction, which is similarly observed in C9orf72 knockdown cells. Mechanistically, SMCR8/C9ORF72 interacts with the key autophagy initiation ULK1 complex and regulates expression and activity of ULK1 PMID: 27617292
  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    SMCR8 family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：


主站蜘蛛池模板： 国产成人亚洲无吗淙合青草 | 成人性生交片无码免费看| 亚洲国产成人片在线观看无码| 国产无遮挡又爽又黄大胸免费| 2021精品亚洲中文字幕| 久久久久国产精品免费免费搜索| 亚洲精品成人无限看| 女人爽到喷水的视频大全| 亚洲精品无码伊人久久| 最近的中文字幕在线看视频| 少妇真实被内射视频三四区| 久久久久国产精品人妻aⅴ天堂| 伊人久久大香线蕉av仙人| 天堂网www在线资源网| 中文在线а天堂中文在线新版| 大肉大捧一进一出视频出来呀 | 亚洲国产成人久久综合一区| 亚洲香蕉视频天天爽| 亚洲一区二区三区无码av| 天天狠天天透天天伊人| 全球av集中精品导航福利| 国产午夜精品一区二区三区老| 亚洲狠狠做深爱婷婷影院| 成人免费毛片aaaaaa片| 男人扒开女人内裤强吻桶进去 | 亚洲色爱免费观看视频| 无码丰满熟妇juliaann与黑人| 精品人妻系列无码人妻免费视频 | 久久久久久久久无码精品亚洲日韩 | 西西人体大胆扒开下部337卩| 日本无码人妻一区二区色欲 | 久久久久99精品成人片| 成在线人免费视频| 国产美女爽到喷出水来视频| 欧美乱强伦xxxx孕妇| 亚洲国产长腿丝袜av天堂| 人人妻人人澡人人爽国产| 无码av喷白浆在线播放| 欧美综合自拍亚洲综合图| 国内精品视这里只有精品| 天下第一社区视频www日本|