在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog (Smcr8), partial

Recombinant Mouse Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog (Smcr8), partial

  • 中文名稱：
    小鼠Smcr8重組蛋白
  • 貨號：
    CSB-YP661046MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Smcr8重組蛋白
  • 貨號：
    CSB-EP661046MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Smcr8重組蛋白
  • 貨號：
    CSB-EP661046MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Smcr8重組蛋白
  • 貨號：
    CSB-BP661046MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Smcr8重組蛋白
  • 貨號：
    CSB-MP661046MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Smcr8
  • Uniprot No.：
  • 別名：
    Smcr8; Guanine nucleotide exchange protein SMCR8; Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates. In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes.
  • 基因功能參考文獻：
    1. C9ORF72 and SMCR8 have interdependent functions in suppressing autoimmunity as well as negatively regulating lysosomal exocytosis-processes of potential importance to amyotrophic lateral sclerosis. PMID: 29950492
    2. We created Smcr8 knockout mice and found that Smcr8 mutant cells exhibit impaired autophagy induction, which is similarly observed in C9orf72 knockdown cells. Mechanistically, SMCR8/C9ORF72 interacts with the key autophagy initiation ULK1 complex and regulates expression and activity of ULK1 PMID: 27617292
  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    SMCR8 family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲国产精品成人综合色| 亚洲sm另类一区二区三区| 精品精品国产理论在线观看| 日韩免费无码成人久久久久久片| 丝袜老师高潮呻吟高潮| 日本少妇浓毛bbwbbwbbw| 成人av一本不卡二卡| 国产精品无码dvd在线观看| 国产精品美女久久久网站| 国产精品无码制服丝袜| 亚洲一区av无码少妇电影| 日日碰狠狠躁久久躁2023| 国产午夜片无码区在线观看爱情网 | 亚洲乱码中文字幕在线| 欧洲美洲精品一区二区三区| 国产精品_国产精品_k频道| 丰满又黄又爽少妇毛片| 欧美性猛交xxxx乱大交| 免费裸体美女网站| 免费无码国产v片在线观看| 一本丁香综合久久久久不卡网站| 亚洲另类欧美小说图片区| 肉体裸交137日本大胆摄影| 香蕉av777xxx色综合一区| 日韩精品一区二区三区中文| 国产69囗曝吞精在线视频| 五十路熟妇强烈无码| 久久人妻少妇嫩草av| 老妇女性较大毛片| 国产又爽又黄无码无遮挡在线观看| 人妻少妇-嫩草影院| 国产无遮挡又黄又爽动态图| 都市激综合小说区另类区| 亚洲a∨无码无在线观看| 蜜臀av午夜一区二区三区| 麻豆蜜桃av蜜臀av色欲av| 鲁鲁夜夜天天综合视频| 日韩电影一区二区三区| 国产成人精品日本亚洲77上位| 久久综合伊人九色综合| 亚洲综合欧美制服丝袜|