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  4. Recombinant Mouse Slit homolog 1 protein (Slit1), partial

Recombinant Mouse Slit homolog 1 protein (Slit1), partial

  • 中文名稱：
    小鼠Slit1重組蛋白
  • 貨號：
    CSB-YP800323MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Slit1重組蛋白
  • 貨號：
    CSB-EP800323MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Slit1重組蛋白
  • 貨號：
    CSB-EP800323MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Slit1重組蛋白
  • 貨號：
    CSB-BP800323MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Slit1重組蛋白
  • 貨號：
    CSB-MP800323MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Slit1
  • Uniprot No.：
  • 別名：
    Slit1; Kiaa0813; Slit homolog 1 protein; Slit-1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.
  • 基因功能參考文獻：
    1. Contralateral migration of oculomotor neurons is regulated by Slit/Robo signaling. Results demonstrate that a migratory subset of motor neurons respond to floor plate-derived Slit repulsion to properly control the timing of contralateral migration. PMID: 27770832
    2. While Slit1 and Robo2 are only expressed in peripheral axons and their cell bodies, Slit2, Slit3 and Robo1 are also expressed in satellite cells of the dorsal root ganglion, Schwann cells and fibroblasts of peripheral nerves. PMID: 28234971
    3. These observations from mutant Slit and Robo mice give great support for Slit/Robo role in neural crest cell migration during Enteric Nervous System development. PMID: 25490618
    4. Data indicate the roles of Slit1/Robo1 and Netrin1/DCC signals in positioning motor neuron cell bodies. PMID: 25530182
    5. a role for Slit1 in corpus callosum development PMID: 22349628
    6. Robo-2-mediated targeting of P2 axons along the dorsoventral axis of the OB is controlled by Slit-1 expression PMID: 22981605
    7. This study demonistrated that production of IPCs is enhanced in Robo1/2 and Slit1/2 mutants, suggesting that Slit/Robo signaling modulates the transition between primary and intermediate progenitors. PMID: 23083737
    8. Disruption of either the Robo1 or Slit1 genes accelerates progression of thalamocortical axons in vivo. PMID: 22772332
    9. Slit1 has a dual context-dependent role in thalamocortical axons formation PMID: 22000108
    10. Robo1 and Robo2 are expressed in the nucleus origin of the tract of the postoptic commissure TPOC (nTPOC), while Slit expression domains flank the TPOC trajectory. PMID: 21688288
    11. Nkx2.9 controls SACMN axon exit from the mammalian spinal cord by regulating Robo-Slit signaling PMID: 22399681
    12. Data show that only Nck2 is required for the Slit1-induced changes in cortical neuron morphology in vitro. PMID: 21600986
    13. These results indicate that Slit1/2 - Robo1/2 signaling is critical during the initial establishment of dopaminergic pathways, with roles in the dorsoventral positioning and precise pathfinding of these ascending longitudinal axons. PMID: 21118670
    14. The results of this study suggested that the Slit1 secreted by new neurons alters the morphology of astrocytes through the astrocytes' Robo receptors, thereby promoting the fast migration of new neurons in contact with the astrocytes. PMID: 20670830
    15. role in antagonizing netrin-1 attractive effects during migration of inferior olivary neurons PMID: 12051827
    16. Slit proteins control the development of the lateral olfactory tract PMID: 12097499
    17. Analysis of alternative splicing and conserved domains in human and mouse slit genes PMID: 12141424
    18. our results suggest that Slit1 signaling may be involved in the regulation of molar tooth shape by regulating epithelial cell proliferation and formation of EFA of the crown. PMID: 12591596
    19. Data suggest that the Slit family of axon guidance molecules (Slit 1-3) and their Robo 1 and 2 receptors contribute to the topographic targeting of basal vomeronasal axons. PMID: 12954717
    20. The Slit receptors Robo2 and Robo3/Rig-1 are expressed in the subventricular zone and the rostral migratory stream and Slit1 and Slit2 are present in the adult septum and are responsible for both the septum and the CP repulsive activity in vitro PMID: 14960623
    21. Experiments with triple mutant mice demonstrate a key role for Slit1 signaling in vertebrate midline commissural axon guidance. PMID: 15091338
    22. In contrast to Sema3F, Slit-1 is dispensable for fasciculation of basal vomeronasal neuron axons but is critical for targeting these axons to the posterior AOB PMID: 15483127
    23. Slit-mediated repolarization consisted of growth of a new process from the previous trailing edge, then reorientation of the neuronal centrosome followed by nuclear translocation in the reverse direction. PMID: 16682216
    24. Slit1 helps prevent retinal ganglion cell axons from crossing the diencephalic/telencephalic boundary in the developing optic tract. PMID: 16828733
    25. We also have found that the lens, which because of its peripheral location within the developing eye is ideally located to influence the initial direction of RGC axon outgrowth, secretes Slit2. PMID: 16885222
    26. Requirement for Slit-1 in zonal segregation of olfactory sensory neuron axons in the main olfactory bulb. PMID: 17715346
    27. The role of Slit1-Robo signaling in the generation, migration and morphological differentiation of cortical interneurons is reported. PMID: 18054781
    28. Slit1 and Slit2 cooperate with Robo1 and Robo2 to control the convergence ofolfactory receptor neuron (ORN) axons to the olfactory bulb and the precise targeting of ORN axons to specific glomeruli. PMID: 18417704
    29. Slit1;Slit2 double mutants had severe longitudinal errors, particularly for ventral axons, including midline crossing and wandering longitudinal trajectories PMID: 18842816
    30. results suggest strongly that Robo2 redundancy with other guidance signals rather than different receptor utilisation is the most likely explanation for the regional specificity of Slit function during intraretinal axon pathfinding PMID: 19782674
    31. expressed in the primary enamel knot of the bud and cap stage tooth germ and later the expression continued in the secondary enamel knots of the late cap and bell stage tooth. PMID: 11520671

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  • 亞細胞定位：
    Secreted.
  • 數據庫鏈接：


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