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  4. Recombinant Mouse Single-stranded DNA-binding protein, mitochondrial (Ssbp1)

Recombinant Mouse Single-stranded DNA-binding protein, mitochondrial (Ssbp1)

  • 中文名稱：
    小鼠Ssbp1重組蛋白
  • 貨號：
    CSB-YP887472MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Ssbp1重組蛋白
  • 貨號：
    CSB-EP887472MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Ssbp1重組蛋白
  • 貨號：
    CSB-EP887472MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Ssbp1重組蛋白
  • 貨號：
    CSB-BP887472MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Ssbp1重組蛋白
  • 貨號：
    CSB-MP887472MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Ssbp1Single-stranded DNA-binding protein; mitochondrial; Mt-SSB; MtSSB
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    17-152
  • 氨基酸序列
    ESEV ASSLVLERSL NRVQLLGRVG QDPVMRQVEG KNPVTIFSLA TNEMWRSGDS EVYQMGDVSQ KTTWHRISVF RPGLRDVAYQ YVKKGARIFV EGKVDYGEYM DKNNVRRQAT TIIAGKKLVV HSVSGCSLEG LA
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK. May also function in mtDNA repair.
  • 基因功能參考文獻：
    1. SSBP1 was down-regulated by Angiotensin II and implicated in cardiac fibrosis through fibroblast proliferation and collagen expression partly via the p53 protein. PMID: 30369577
    2. SSBp1 deletion results in increased chromosomal aberrations and localizes to telomeres and participate in the repair of uncapped telomeres. PMID: 23459151
  • 亞細胞定位：
    Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.
  • 組織特異性：
    Expressed in all the layers of the retina (at protein level).
  • 數據庫鏈接：


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