在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Sialidase-3 (Neu3)

Recombinant Mouse Sialidase-3 (Neu3)

In Stock
  • 中文名稱：
    小鼠Neu3重組蛋白
  • 品名簡稱：
    Recombinant Mouse Neu3 protein
  • 貨號：
    CSB-EP872896MO
  • 說明書：
  • 規格：
    ￥2328
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Neu3
  • Uniprot No.：
  • 別名：
    Neu3Sialidase-3; EC 3.2.1.18; Ganglioside sialidase; Membrane sialidase; N-acetyl-alpha-neuraminidase 3
  • 種屬：
    Mus musculus(Mouse)
  • 蛋白長度：
    Full Length
  • 來源：
    E.coli
  • 分子量：
    52.9 kDa
  • 表達區域：
    1-418aa
  • 氨基酸序列
    MEEVPPYSLSSTLFQQEEQSGVTYRIPALLYLPPTHTFLAFAEKRTSVRDEDAACLVLRRGLMKGRSVQWGPQRLLMEATLPGHRTMNPCPVWEKNTGRVYLFFICVRGHVTERCQIVWGKNAARLCFLCSEDAGCSWGEVKDLTEEVIGSEVKRWATFAVGPGHGIQLHSGRLIIPAYAYYVSRWFLCFACSVKPHSLMIYSDDFGVTWHHGKFIEPQVTGECQVAEVAGTAGNPVLYCSARTPSRFRAEAFSTDSGGCFQKPTLNPQLHEPRTGCQGSVVSFRPLKMPNTYQDSIGKGAPATQKCPLLDSPLEVEKGAETPSATWLLYSHPTSKRKRINLGIYYNRNPLEVNCWSRPWILNRGPSGYSDLAVVEEQDLVACLFECGEKNEYERIDFCLFSDHEVLSCEDCTSPSSD
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Tris-based buffer，50% glycerol
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes.
  • 基因功能參考文獻：
    1. the expression of neuraminidases in induced regulatory T (iTreg) cells was investigated in comparison with that in other T-cell subsets and concluded that Neu3 contributes to the differentiation of iTreg cells by upregulation of FoxP3. PMID: 29271120
    2. radiographs revealed abnormalities in the skeletal bones of the Hexa(-/-)Neu3(-/-) mice PMID: 28974375
    3. These results suggest that NEU3 activity on exosome glycans enhances the dynamic biological behavior of these small extracellular vesicles by modifying the negative charge and steric hindrance of their glycocalyx, and that the presence of NEU3 on the exosomal surface could represent a useful marker for the detection of these nanovesicles PMID: 29039925
    4. These results provide the first in vivo evidence that neuraminidases 3 and 4 have important roles in CNS function by catabolizing gangliosides and preventing their storage in lipofuscin bodies. PMID: 28442549
    5. findings implicate NEU3 as a potential biomarker of insulin sensitivity, and provide novel mechanistic insight into the regulation of NEU3 expression. PMID: 26022181
    6. NEU3 regulates the detergent resistant membrane ganglioside content. PMID: 24925219
    7. NEU3 up-regulation stimulates the EGF receptor signaling pathway, which in turn activates the hypoxia-inducible factor (HIF-1alpha), resulting in a final increase of cell survival and proliferation. PMID: 23209287
    8. NEU3 plays an important role in inflammation-dependent tumor development PMID: 22815940
    9. Data indicate that sialidases Neu1 and Neu3 are present on sperm, and their activity is required for capacitation and zona pellucida binding. PMID: 22989879
    10. The work further supports the central role of NEU3 as a key modulator in skeletal muscle differentiation, particularly in the myoblast fusion step. PMID: 22552967
    11. It exists in membrane microdomains and regulates signal transductions. (review) PMID: 21089368
    12. NEU3 participates in the control of insulin signaling via modulation of gangliosides and interaction with Grb2 PMID: 12730204
    13. MmNEU3 is able to hydrolyze ganglioside substrates in intact living cells at a neutral pH, mainly through cell-to-cell interactions PMID: 14970224
    14. NEU3 is able to mobilize to membrane ruffles in response to growth stimuli and activate the Rac-1 signaling by co-localization with Rac-1, leading to increased cell motility. PMID: 16765317
    15. Reduction of 70% of the plasma membrane-associated sialidase Neu3 activity caused neurite elongation in Neuro2a murine neuroblastoma cells. PMID: 17176265
    16. findings suggest that the Neu3 gene represents a physiological modulator of VSMC responses that may contribute to plaque instability in atherosclerosis. PMID: 17382908
    17. The decrease of GD1a in COS7 cell membrane upon MmNEU3 over-expression is likely to be instrumental to Newcastle Disease Virus reduced infection. PMID: 18155174
    18. NEU3 sialidase strictly modulates GM3 levels in skeletal myoblasts C2C12 thus favoring their differentiation and protecting them from apoptosis PMID: 18945680
    19. Plasma membrane-associated sialidase (Neu3) promotes formation of colonic aberrant crypt foci in azoxymethane-treated transgenic mice. PMID: 19215228

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Peripheral membrane protein. Membrane, caveola. Early endosome membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Lysosome membrane; Peripheral membrane protein.
  • 蛋白家族：
    Glycosyl hydrolase 33 family
  • 組織特異性：
    Expressed in heart, brain and cerebral cortex.
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲人成人无码www影院| 欧美性生交活xxxxxdddd| 国产 日韩 另类 视频一区| 中文字幕乱码免费| 四虎影成人精品a片| 精品一区二区三人妻视频 | 青青草视频在线观看| 日本中国内射bbxx| 亚洲精品一区二区丝袜图片 | 婷婷五月综合色视频| 午夜伦yy44880影院| 国产成人无码a区在线观看视频app | 欧美日韩在大午夜爽爽影院| 偷拍区清纯另类丝袜美腿| 国产精品久久无码不卡| 99热成人精品国产免费 | 冲田杏梨av一区二区三区 | 国产亚洲精品aaaa片小说| 日韩国产亚洲欧美中国v| 人妻熟女久久久久久久| 亚洲精品一区二区三区四区乱码 | 亚洲中文字幕无码中文字在线| 亚洲精品无码mⅴ在线观看| a级大胆欧美人体大胆666| 色视频www在线播放国产人成 | 国产97色在线 | 日| 男女啪啪进出阳道猛进| 亚洲成av人片一区二区密柚| 新区乱码无人区二精东| 人妻中文乱码在线网站| 国产精品亚洲lv粉色| 国产成人综合色视频精品| 人妻系列无码专区无码中出| 亚洲第一成人网站| 日本熟妇色xxxxxhd| 护士av无码在线观看| 精品无码国产av一区二区三区| 久久se精品一区精品二区| 色悠久久久久综合先锋影音下载| 熟妇人妻无码中文字幕| 处破痛哭a√18成年片免费 |