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  4. Recombinant Mouse Short transient receptor potential channel 5 (Trpc5), partial

Recombinant Mouse Short transient receptor potential channel 5 (Trpc5), partial

  • 中文名稱：
    小鼠Trpc5重組蛋白
  • 貨號：
    CSB-YP886162MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Trpc5重組蛋白
  • 貨號：
    CSB-EP886162MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Trpc5重組蛋白
  • 貨號：
    CSB-EP886162MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Trpc5重組蛋白
  • 貨號：
    CSB-BP886162MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Trpc5重組蛋白
  • 貨號：
    CSB-MP886162MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Trpc5; Trp5; Trrp5; Short transient receptor potential channel 5; TrpC5; Capacitative calcium entry channel 2; CCE2; Transient receptor protein 5; TRP-5; mTRP5; Trp-related protein 5
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1.
  • 基因功能參考文獻：
    1. TRPC5 may not have a pivotal role in baroreflex regulation PMID: 29572499
    2. Results suggest that activation of transient receptor potential channel 5 (TRPC5) contributes to the development of cholestasis and associated dyslipidemia. PMID: 28539583
    3. TRPC5 channels represent a key pressure transducer in the baroreceptors and play an important role in maintaining blood pressure stability. PMID: 27411851
    4. Transient receptor potential canonical 5 (TRPC5) protects against pain and vascular inflammation in arthritis and joint inflammation. PMID: 27165180
    5. that Arg-593, a residue located in the E4 loop near the TRPC5 extracellular Gd(3+) binding site, is critical for conferring the sensitivity to GPCR-Gq/11-PLC-dependent gating on TRPC5. PMID: 27920205
    6. novel functions of TRPC5 in regulating vascular aging PMID: 28237267
    7. TRPC5 contributes to depolarization of the plasma membrane in gonadotropes upon GnRH stimulation and increases the intracellular Ca2+ concentration via its own Ca2+ permeability and via the activation of voltage-gated Ca2+ channels. PMID: 28324107
    8. Riluzole can activate TRPC5 heterologously expressed in HEK293 cells as well as those endogenously expressed in the U-87 glioblastoma cell line. PMID: 24117252
    9. Loss or inhibition of TRPC5 abrogates podocyte cytoskeletal remodeling, prevents Rac1 activation, & stabilizes synaptopodin. Genetic deletion or pharmacologic inhibition of TRPC5 protected mice from albuminuria. PMID: 24231357
    10. NEB cells selectively expressed the Ca(2+)-permeable osmo- and mechanosensitive TRPC5 in their apical membranes, whereas immunoreactivity for TRP vanilloid-4 and TRP melastatin-3 was abundant in virtually all other airway epithelial cells PMID: 22461428
    11. TRPC5 acts downstream of semaphorin signaling to cause changes in neuronal growth cone morphology and nervous system development. PMID: 22547824
    12. a novel function for TRPC5 that couples calcium signaling to a ubiquitin ligase pathway at the centrosome and thereby orchestrates dendrite patterning and connectivity in the brain PMID: 22135323
    13. findings demonstrate that highly cold-sensitive TRPC5 channels are a molecular component for detection and regional adaptation to cold temperatures in the peripheral nervous system that is distinct from noxious cold sensing PMID: 22025699
    14. The results of this study strongly suggested that the TRPC5 play a role in the CO(2) chemosensitivity of locus coeruleus. neurons. PMID: 21430274
    15. Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels. PMID: 20978238
    16. Nitric oxide donors fail to modulate activity of mouse TRPC5 channels exogenously expressed in HEK293 cells. PMID: 20390293
    17. mTRP5 might be a candidate for the nonselective cation channel activated by ACh or CCh in murine stomach. PMID: 12631560
    18. Electrostatic attraction of cations by D633 may contribute to inward current amplitude in TRPC5. Cytosolic negatively charged residues can modulate the conductivity of TRP cation channels. PMID: 15689561
    19. the desensitization of TRPC5 occurs via PKC phosphorylation and threonine at residue 972 of mouse TRPC5 might be required for its phosphorylation by PKC. PMID: 15843439
    20. These results demonstrate that intracellular calcium has dual and opposite effects on the activation of TRPC5. PMID: 15987684
    21. Results suggest that calmodulin and myosin light chain kinase modulate the activation process of transient receptor potential channel 5. PMID: 16306123
    22. TRPC5 calcium channel has a lysophospholipid-sensing capability that confers the property of a lipid ionotropic receptor PMID: 16368680
    23. New regulatory mechanism for TRPC5 channels. B subunit of cholera toxin-induced Ca2+ influx is mediated by TRPC5 channels. PMID: 17626205
    24. analysis of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement PMID: 18495872
    25. TRPC5 channels are activated by osmo-mechanical stimuli. TRPC5 channels are expressed in sensory neurones, which together with the osmo-mechanical characteristics of TRPC5 channels suggest its putative role in mechanosensory transduction events. PMID: 18832422
    26. GM1 in T-effector cells to be the primary target of Gal-1 expressed by Treg cells, the resulting co-cross-linking and TRPC5 channel activation contributing importantly to the mechanism of autoimmune suppression PMID: 19299701
    27. Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. PMID: 19398778
    28. These experiments provide genetic evidence that TRPC5, activated via G protein-coupled neuronal receptors, has an essential function in innate fear. PMID: 19450521
    29. TRPC5 forms Ca(2+)-activated cation channels that are functionally coupled to Ca(2+)-selective ion channels through local Ca(2+) increases beneath the plasma membrane PMID: 19815560

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC5 sub-subfamily
  • 組織特異性：
    Expressed almost exclusively in brain, in mitral cells of the olfactory bulb, in lateral cerebellar nuclei and in pyramidal neurons of the hippocampus. Very low levels detected in liver kidney, testis, and uterus.
  • 數據庫鏈接：


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