在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Serum amyloid A-3 protein (Saa3), partial

Recombinant Mouse Serum amyloid A-3 protein (Saa3), partial

In Stock
  • 中文名稱：
    小鼠Saa3重組蛋白
  • 貨號：
    CSB-EP361411MO
  • 規(guī)格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP361411MO could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) SAA3.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP361411MO could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) SAA3.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Saa3
  • Uniprot No.：
  • 別名：
    Saa3; Serum amyloid A-3 protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    partial
  • 來源：
    E.coli
  • 分子量：
    15.8kDa
  • 表達(dá)區(qū)域：
    20-122aa
  • 氨基酸序列
    RWVQFMKEAGQGSRDMWRAYSDMKKANWKNSDKYFHARGNYDAARRGPGGAWAAKVISDAREAVQKFTGHGAEDSRADQFANEWGRSGKDPNHFRPAGLPKRY
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產(chǎn)品描述：

    The preparation of this recombinant Mouse Saa3 protein was to use gene recombination DNA technology to obtain a recombinant vector connected with a Saa3 fragment (20-122aa) that could be translated into the Saa3 protein and then transferred it into E.coli cells to express the recombinant Saa3 protein molecule. In order to get the target protein with high purity, N-terminal 6xHis tag was used in the production. The purity is 90% determined by SDS-PAGE.

    Serum amyloid A3 (Saa3) derives mainly from extrahepatic tissue and is not detected in plasma from moderately inflamed obese mice. In contrast, it is present in plasma from mice acutely inflamed by injection of high dose of lipopolysaccharide (LPS). To reconcile these differences, we evaluated whether different acute inflammatory stimuli could affect the presence of Saa3 in plasma. Saa3 appeared dose dependently in plasma after LPS injection. In contrast, only very low levels were detected after sterile inflammation with silver nitrate despite levels of Saa1 and Saa2 being comparable to high dose LPS. Saa3 was not detected in plasma following casein administration. Although most Saa3 was found in HDL, a small amount was not lipoprotein associated. Saa3 is commonly regarded as an extrahepatic form of Saa secreted by cells such as macrophages and adipocytes in species such as mice, although it also can be made at low levels by hepatocytes. SAA3 is a pseudogene in humans and some primates because of a frameshift mutation that generates a downstream stop signal, such that no SAA3 mRNA or SAA3 protein has been identified in humans.

  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價(jià)

問答及客戶評論

■ 常見問題解答
Q:

We request pricing for the following:
500ug of CSB-EP361411MO (lot #03119), endotoxin-removal
200ug of CSB-EP361411MO (lot #03119), with endotoxin-removal performed multiple times (at least twice)
Are there any extra charges for performing endotoxin-removal twice?

A:
Sorry, we can only guarantee that the final endotoxin level is less than 1EU/ug, what's your requirement for the endotoxin level ?
We worry about that the final endotoxin level will not be extremely low even if we perform multiple times.
There isn't any extra charges for performing endotoxin-removal twice, but we can't guarantee to meet your demand.
Lead time is the same for one time or multiple times endotoxin removal operation,and there is no extra charges.

靶點(diǎn)詳情

  • 功能：
    Major acute phase reactant. Apolipoprotein of the HDL complex.
  • 基因功能參考文獻(xiàn)：
    1. High SAA3 expression in the stromal component is associated with pancreatic tumors. PMID: 29351990
    2. This study suggests that the level of expression of the Saa3 gene could be utilized for the number of infiltrated macrophages in obese adipose tissue. PMID: 27929048
    3. BMDC lacking SAA3 demonstrate an impaired endotoxin tolerance response and inhibited responses to retinoic acid. Our findings indicate that endogenous SAA3 modulates metabolic and immune homeostasis PMID: 29390039
    4. The induction of Saa3 by PTH may explain the suppression of bone formation when PTH is applied continuously and may be a new therapeutic target for osteoporosis. PMID: 26703472
    5. results also suggest that Saa3 influences liver-specific SAA1/2 expression, and that SAA3 could play a larger role in the acute phase response than previously thought PMID: 25251243
    6. Expression of Saa3 in osteoblasts positively correlates with increased cellular maturation toward the osteocyte phenotype. PMID: 25491310
    7. Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection. PMID: 25073702
    8. these data suggest a novel mechanism by which Mo MDSCs mediate inflammation through SAA3-TLR2 signaling and thus exacerbate cancer progression by a STAT3-dependent mechanism. PMID: 24659444
    9. Hypoxia leads to a substantial increase in SAA3 mRNA and protein level, apparently in a time-dependent manner (threefold in 48 h), in fully differentiated 3T3-L1, followed by reestablishment of gene expression to basal levels after 24 h of reoxygenation. PMID: 23605472
    10. Using various synthetic peptide fragments, it was shown that SAA3 directly binds MD-2 and activates the MyD88-dependent TLR4/MD-2 pathway, induced IL-6 and TNF-alpha, and recruited CD11b(+)Gr-1(+) cells to the lung. PMID: 23858030
    11. HSV-1 induces and activate TLR2 and TLR4 receptors directly through interaction of astrocytes with the pathogen and also indirectly by endogenous ligands produced locally, such as serum amyloid A, potentiating the neuroinflammatory response. PMID: 22622619
    12. Saa3 is expressed in the lungs of mice exposed to several mixed T helper (Th) type 2/Th17-polarizing allergic sensitization regimen and is implicated in the pathogenesis of experimental allergic asthma. PMID: 21622869
    13. cAMP in combination with TNF specifically induced C/EBPbeta protein, leading to enhanced SAA3 expression but requiring NF-kappaB in mouse granulose cells. The data indicate SAA may play a role in events occurring during the ovulation process. PMID: 20444945
    14. A 210-bp fragment of the mouse SAA3 promoter when placed in front of the LacZ gene was sufficient to confer basal and inflammation-induced reporter gene expression. PMID: 11791617
    15. tumor necrosis factor-alpha likely increased serum amyloid A 3 promoter activity and protein by activating nuclear factor-kappaB signaling via tumor necrosis factor receptor 1 in mouse granulosa cells PMID: 14749357
    16. Adipocyte hypertrophy leads to increased production of SAA and hyaluronan, which srecruit and retains monocytes, thereby leading to local inflammation in adipose tissue. PMID: 17563062
    17. These data show a potent upregulation of SAA3 by IL-1beta. PMID: 18452164
    18. In adipose tissue Saa3 was the predominant isoform and the earliest inflammatory marker induced, suggesting it is important for initiation of adipose tissue inflammation. PMID: 18584041
    19. Results indicate that the expression of SAA3 in adipose tissue is upregulated by obesity, but it does not contribute to the circulating pool of SAA in mice. PMID: 19286646
    20. serum amyloid A3 (SAA3) is regulated in mouse colonic epithelium and adipose tissue by the intestinal microbiota PMID: 19513118

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    SAA family
  • 組織特異性：
    Found in various tissues.
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 97色伦97色伦国产欧美| 337p日本欧洲亚洲大胆色噜噜| 在线综合亚洲欧洲综合网站| 亚洲人成在线观看影院牛大爷| 又黄又爽的60分钟视频| 精品国产人妻一区二区三区| 女人色极品影院| 免费人成网视频在线观看| 96亚洲精华国产精华精华液| 欧美成人一区二免费视频软件| 亚洲精品久久久久久无码色欲四季| 亚洲综合精品第一页| 亚洲人成77777在线播放网站不卡 国产 | 欧洲野花视频天堂视频p 亚洲aⅴ天堂av天堂无码 | 国产精品1区2区3区在线观看| 日韩在线视频线观看一区| 亚洲日韩精品无码专区加勒比海 | 又黄又湿啪啪响18禁| 色综合久久久久久久久五月| 亚洲成a人v影院色老汉影院| 中文字幕人妻熟女人妻a片| 色94色欧美sute亚洲线路一| 午夜福利理论片高清在线观看| 国产三级精品三级在线观看| 久久99精品国产麻豆| 亚洲 欧美 另类图片| 国产免费二卡3卡四卡| 久久久久久av无码免费看大片| 天堂在线中文网www| 制服丝袜有码中文字幕在线| 无码日韩精品一区二区免费暖暖| 国产成人亚洲综合无码精品| 五月丁香六月激情综合在线视频| 国产网曝门亚洲综合在线| 午夜影视免费| 精品国产综合区久久久久久| 欧美牲交视频免费观看| 在教室伦流澡到高潮hgl视频| 精品人妻伦一二三区久久| 日韩精品真人荷官无码| 超清中文乱码一区| 国产人妻人伦精品1国产丝袜|