在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Serine/threonine-protein phosphatase 6 catalytic subunit (Ppp6c)

  • 中文名稱:
    小鼠Ppp6c重組蛋白
  • 貨號:
    CSB-YP863425MO
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    小鼠Ppp6c重組蛋白
  • 貨號:
    CSB-EP863425MO
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    小鼠Ppp6c重組蛋白
  • 貨號:
    CSB-EP863425MO-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    小鼠Ppp6c重組蛋白
  • 貨號:
    CSB-BP863425MO
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    小鼠Ppp6c重組蛋白
  • 貨號:
    CSB-MP863425MO
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Ppp6c; Serine/threonine-protein phosphatase 6 catalytic subunit; PP6C; EC 3.1.3.16
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-305
  • 氨基酸序列
    MAPLDLDKYV EIARQCKYLP ENDLKRLCDY VCDLLLEESN VQPVSTPVTV CGDIHGQFYD LCELFRTGGQ VPDTNYIFMG DFVDRGYYSL ETFTYLLALK AKWPDRITLL RGNHESRQIT QVYGFYDECQ TKYGNANAWR YCTKVFDMLT VAALIDEQIL CVHGGLSPDI KTLDQIRTIE RNQEIPHKGA FCDLVWSDPE DVDTWAISPR GAGWLFGAKV TNEFVHINNL KLICRAHQLV HEGYKFMFDE KLVTVWSAPN YCYRCGNIAS IMVFKDVNTR EPKLFRAVPD SERVIPPRTT TPYFL
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation.
  • 基因功能參考文獻:
    1. Ppp6c deficiency enhances K-ras(G12D) -dependent tumor promotion PMID: 29758119
    2. the Ppp6c phosphatase domain is indispensable for mouse embryogenesis after implantation. PMID: 26868000
    3. findings uncover a hitherto unknown role for PP6 as an indispensable regulator of oocyte meiosis and female fertility. PMID: 26349807
    4. Data identify NF-kappaB-induced miR-31 and its target, ppp6c, as critical factors for the hyperproliferation of epidermis in psoriasis. PMID: 26138368
    5. Ppp6c deficiency predisposes mice to skin carcinogenesis initiated by DMBA. PMID: 25486434
    6. Ppp6c deficiency underlies molecular events that drive outgrowth of initiated keratinocytes harboring UVB-induced mutated p53 PMID: 26054846
    7. Our studies demonstrate that PP6 acts as a critical negative regulator of naive T cell homeostasis PMID: 25609840
    8. PP6 regulates the sensitivity of GBM cells to radiation, and suggest small molecules disrupting or inhibiting PP6 association with DNA-PK is a potential radiosensitizer for GBM. PMID: 22158480
    9. alpha4 expression differentially increased or decreased phosphorylation of endogenous phosphoproteins, consistent with opposing effects on PP2A and PP6 [PP6] PMID: 16895907

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion. Cytoplasm.
  • 蛋白家族:
    PPP phosphatase family, PP-6 (PP-V) subfamily
  • 組織特異性:
    Ubiquitously expressed in all tissues tested with strongest expression in lung, spleen, liver, kidney and brain. Weaker expression observed in bladder, pancreas, heart and skeletal muscle.
  • 數據庫鏈接:


主站蜘蛛池模板: 欧美交换国产一区内射| 柠檬福利精品视频导航| 午夜高清在线无码| 国产开嫩苞实拍在线播放视频| 无码精品一区二区三区免费视频 | 无码人妻丰满熟妇区bbbbxxxx| 一个人看的日本hd免费| 国产日韩精品欧美一区喷水| 午夜无码片在线观看影院y| 亚洲卡一卡二乱码新区仙踪| 亚洲狠狠婷婷综合久久| 一本久道高清无码视频| 久久久亚洲欧洲日产国码αv| 日韩美女自卫慰黄网站| 2021国产成人精品久久| 四虎免费大片aⅴ入口| 国产青草视频在线观看| 亚洲 日本 欧美 中文字幕| 久久精品免费一区二区三区| 人妻巨大乳一二三区| 亚洲阿v天堂在线| 亚洲香蕉aⅴ视频在线播放| 无码啪啪熟妇人妻区 | 国产精品第12页| 50岁退休熟女露脸高潮| av蓝导航精品导航| 国产三级在线观看播放视频 | 熟妇人妻中文av无码| 亚洲国产精品嫩草影院永久| 无码av无码天堂资源网影音先锋| 99久久精品费精品国产一区二区 | 国产在热线精品视频| 日本内射精品一区二区视频| 色综合久久久无码中文字幕| 亚洲最大激情中文字幕| 羞羞影院午夜男女爽爽免费| 亚洲亚洲人成综合网络| 国产欧美二区综合| 亚洲精品无码成人片久久| 老熟妇性老熟妇性色| 亚洲精品国偷拍自产在线观看蜜臀 |