Recombinant Mouse Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (Ppp2cb)

中文名稱：

小鼠Ppp2cb重組蛋白
貨號：

CSB-YP352946MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

小鼠Ppp2cb重組蛋白
貨號：

CSB-EP352946MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

小鼠Ppp2cb重組蛋白
貨號：

CSB-EP352946MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Ppp2cb重組蛋白
貨號：

CSB-BP352946MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Ppp2cb重組蛋白
貨號：

CSB-MP352946MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Ppp2cb
Uniprot No.：

P62715
別名：

Ppp2cb; Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; PP2A-beta; EC 3.1.3.16
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區(qū)域：

1-309
氨基酸序列

MDDKAFTKEL DQWVEQLNEC KQLNENQVRT LCEKAKEILT KESNVQEVRC PVTVCGDVHG QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL VALKVRYPER ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF DYLPLTALVD GQIFCLHGGL SPSIDTLDHI RALDRLQEVP HEGPMCDLLW SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA HQLVMEGYNW CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV TRRTPDYFL
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
基因功能參考文獻：
1. PP2B-Abeta limits platelet response to vascular injury by suppressing outside-in alphaII b beta3 integrin signaling PMID: 25330904
2. PP2A activation via rapid, non-nuclear ER signaling may be a novel target for therapeutic approaches to inhibit vascular smooth muscle proliferation, which plays a central role in atherosclerosis and restenosis. PMID: 23744991
3. calcineurin signaling plays a critical role in regulating skeletal muscle fiber type switching but not hypertrophy PMID: 12773574
4. PP2A/C provides a dual inhibitory effect on Bcl2's survival function by both dephosphorylating Bcl2 and enhancing p53-Bcl2 binding. PMID: 18845789
亞細胞定位：

Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole.
蛋白家族：

PPP phosphatase family, PP-1 subfamily
數(shù)據(jù)庫鏈接：

KEGG: mmu:19053

STRING: 10090.ENSMUSP00000009774

UniGene: Mm.288765