在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Serine/threonine-protein kinase Nek1 (Nek1), partial

Recombinant Mouse Serine/threonine-protein kinase Nek1 (Nek1), partial

  • 中文名稱：
    小鼠Nek1重組蛋白
  • 貨號：
    CSB-YP015696MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Nek1重組蛋白
  • 貨號：
    CSB-EP015696MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Nek1重組蛋白
  • 貨號：
    CSB-EP015696MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Nek1重組蛋白
  • 貨號：
    CSB-BP015696MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Nek1重組蛋白
  • 貨號：
    CSB-MP015696MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Nek1
  • Uniprot No.：
  • 別名：
    Nek1; Serine/threonine-protein kinase Nek1; EC 2.7.11.1; Never in mitosis A-related kinase 1; NimA-related protein kinase 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis. Involved in cilium assembly.
  • 基因功能參考文獻：
    1. NEK1 phosphorylates PP1gamma, leading to the dephosphorylation of WAPL, which, in turn, results in its retention on chromosome cores to promote loss of cohesion at the end of prophase I in mammals. PMID: 27760328
    2. Nek1 is detectable in all murine tissues but its expression in wild type and kat2J heterozygous kidneys decrease as the kidneys mature. In the embryonic kidney, Nek1 expression is most prominent in cells that will become podocytes and proximal tubules. PMID: 25030234
    3. results demonstrate that Nek1 is important for proper checkpoint control and characterize for the first time a DNA damage response that does not directly involve one of the known upstream mediator kinases, ATM or ATR PMID: 21301226
    4. data suggest that TAZ and Nek1 constitute a negative feedback loop linked through phosphorylation and ubiquitination and that the interaction of Nek1 and TAZ maintain polycystin 2 at the level needed for proper ciliogenesis PMID: 21474562
    5. NEK1 is required for the maintenance of genome stability by acting at multiple junctures, including control of chromosome stability PMID: 21214959
    6. Nek1 may function as a kinase early in the DNA damage response pathway. PMID: 15604234
    7. Murine NIMA-related kinase, Nek1, is larger than previously reported, and that the full-length protein conserves the structural hallmarks of NIMA PMID: 16603261
    8. Nek1 links cell cycle progression and the primary cilium cycle. PMID: 18387364
    9. we propose that Nek1 plays a role in centrosome integrity, affecting both ciliogenesis and centrosome stability PMID: 18533026
    10. These data show that Nek1 is important for efficient DNA damage checkpoint control and for proper DNA damage repair. PMID: 18843199
    11. NEK1 is a candidate to transduce messages from the ciliary-basal body region to the regulation of nuclear gene expression. PMID: 19699716

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
  • 蛋白家族：
    Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
  • 組織特異性：
    Predominantly in testes (germ cells and Sertoli cells). Lower levels in ovary (oocytes and granulosa cells), thymus and lung.
  • 數據庫鏈接：


主站蜘蛛池模板： 99er国产这里只有精品视频免费| 北条麻妃在线一区二区| 中国妇女做爰视频| 97色偷偷色噜噜狠狠爱网站97 | 欧美老妇疯狂xxxxbbbb| 亚洲精品久久久久久中文传媒| 久久五月精品中文字幕| 国产在线观看无码的免费网站 | 成人无码www在线看免费| 天天爱天天做久久狠狠做| 国产偷国产偷亚州清高app| 亚洲a∨国产av综合av下载| 日本高清视频网站www| 美日欧激情av大片免费观看| 亚洲成a人片在线观看你懂的| 国产强被迫伦姧在线观看无码| 亚洲熟妇无码av另类vr影视| 久久久久国色av∨免费看| 无尺码精品产品网站| 中文字幕乱码亚洲精品一区| 亚洲曰本av在线天堂| 2022一本久道久久综合狂躁| 艳妇臀荡乳欲伦交换h在线观看| 国产精品丝袜久久久久久不卡| 国产按头口爆吞精在线视频| 久久狠狠色噜噜狠狠狠狠97| 国产精品自在在线午夜| 8x福利精品第一导航| 亚洲欧美中文字幕高清在线| 亚洲色欲色欱www在线| 六月丁香婷婷色狠狠久久| 999成人精品视频在线| 国产香蕉97碰碰久久人人| 亚洲熟熟妇xxxx| 久久亚洲国产精品影院| 国产精品亚洲欧美中字| 亚洲精品国偷拍自产在线观看蜜臀| 人妻少妇精品视频无码综合| 亚洲无线观看国产精品| 日本japanese丰满多毛| 色噜噜av男人的天堂|