在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Serglycin (Srgn)

Recombinant Mouse Serglycin (Srgn)

In Stock
  • 中文名稱：
    小鼠Srgn重組蛋白
  • 貨號：
    CSB-EP022664MO
  • 說明書：
  • 規格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Srgn
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    E.coli
  • 分子量：
    15.3 kDa
  • 表達區域：
    75-152aa
  • 氨基酸序列
    EGPSKDFISNYDDYGSGSGSGSGSGSGSGSGSGSGFLGDMEWEYQPTDESNIVYFNYKPFDRILTEQNQDQPEDDFII
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    C-terminal 6xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
  • 基因功能參考文獻：
    1. serglycin produced in lipopolysaccharide-induced inflammation in normal mouse chondrocytes is able to modulate inflammation by interacting with CD44 receptor, suggesting a possible key role in the cartilage inflammation. PMID: 29588174
    2. Findings indicate that PRG-1 deficiency led to over-excitability caused by an altered LPA/LPA2-R signaling inducing a behavioral phenotype typically observed in animal models for psychiatric disorders. PMID: 28843862
    3. this study shows that the serglycin-deficient mice are more susceptible to Trichinella spiralis infection and display an unbalanced immune response PMID: 27267469
    4. Data suggest that serglycin proteoglycans play a role in extravasation as well as colonization and growth of metastatic cells. PMID: 27223472
    5. serglycin deficient mice exhibited elevated concentrations of serum LDL after feeding high-fat diet for 20 weeks. PMID: 26391682
    6. Dopamine storage increased during mast cell maturation from bone marrow precursors, and was dependent on the presence of serglycin. PMID: 22628305
    7. Cells lacking mouse mast cell protease 6 exhibited similar defects in apoptosis as observed in serglycin(-/-) cells, indicating that the pro-apoptotic function of serglycin is due to downstream effects of proteases that are complex-bound to serglycin PMID: 22493512
    8. The PRG-1 transcription is initiated at multiple transcription start site and no influence on expression in vivo by Nex1 deficiency. PMID: 21805347
    9. serglycin proteoglycan as a novel player in mast cell apoptosis. PMID: 21123167
    10. serglycin proteoglycan is dispensable for normal secretion and activity of mast cell proteases in response to peritoneal infection with T. gondii. PMID: 20864536
    11. SG proteoglycan has a key role in mast cell function PMID: 15231821
    12. serglycin is the major proteoglycan secreted by peritoneal macrophages and the macrophage serglycin may have a role in regulating secretion of tumor necrosis factor-alpha PMID: 16807245
    13. The reduced amounts of proteases in the absence of serglycin is not caused by missorting, but rather that serglycin may be involved in the retention of the proteases after their entry into secretory vesicles PMID: 17010166
    14. Serglycin is of crucial importance for assembly of mature mucosal mast cell granules, but the specific dependence on SG for storage varies between individual granule constituents. PMID: 17147513
    15. Neutrophil elastase depends on serglycin proteoglycan for localization in granules. PMID: 17272511
    16. SG is crucial for platelet function and thrombus formation PMID: 18094327
    17. Histamine and serotonin storage in mast cells is dependent on serglycin proteoglycan. PMID: 18234316
    18. the present report points to a novel, previously unrecognized role for serglycin proteoglycan in regulating the kinetics of antiviral CD8(+) T cell responses PMID: 18606656
    19. These findings are thus in accordance with a role for the N-terminal disulfide motif in serglycin for regulation of mast cell secretory granule integrity. PMID: 19059647
    20. SGC deficiency causes multiple, age-related effects on the lymphoid system PMID: 19088175
    21. mast cell maturation is associated with the expression of a distinct signature of genes involved in serglycin proteoglycan synthesis, and that mast cell activation modulates their expression. PMID: 19915053

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasmic granule. Cytolytic granule. Secreted, extracellular space. Golgi apparatus.
  • 蛋白家族：
    Serglycin family
  • 數據庫鏈接：


主站蜘蛛池模板： 大胸少妇午夜三级| 亚洲精品乱码一区二区三区| 蜜桃麻豆www久久国产sex| 黑人大荫道bbwbbb高潮潮喷| 国产亚洲精品美女久久久久| 日韩中文高清在线专区| 亚洲va无码va在线va天堂| 女学生14毛片视频片二毛 | 男人狂躁进女人下面免费视频| 国产精品久久久久久av| 成人欧美日韩一区二区三区| 国产情侣大量精品视频| 无码精品一区二区三区免费视频| 少妇人妻大乳在线视频| 国产精品99久久精品爆乳| 亚洲熟女综合一区二区三区| 天天摸天天做天天爽天天弄| 久久人妻夜夜做天天爽| 國产一二三内射在线看片 | 中文字幕无码日韩专区| 人妻av无码系列一区二区三区| 亚洲国产av精品一区二区蜜芽| 色欲av无码一区二区人妻 | 国内免费视频成人精品| 亚洲欧美日韩一区在线观看| 日本丰满少妇裸体自慰| 国产精品老汉av| 中文字幕在线不卡精品视频99| 国产三级在线观看完整版| 亚洲自偷自偷图片| 亚洲精品日韩一区二区小说| 国产产品亚洲产品| 天天做天天爱夜夜夜爽毛片| 亚洲vs日韩vs欧美vs久久| 久久久久国色av∨免费看| 豆国产95在线 | 亚洲| 久久久久有精品国产麻豆| 欧美性video高清精品| 性动态图av无码专区| 女人被狂躁c到高潮| 亚洲综合电影小说图片区|